Impairment in activation of a frontal attention-switch mechanism in schizophrenic patients

Sato, Yasuharu; Yabe, Hirooki; Todd, Juanita; Michie, Patricia T.; Shinozaki, Naoko; Sutoh, Takeyuki; Hiruma, Tomiharu; Nashida, Tadayoshi; Matsuoka, Takashi; Kaneko, Sunao

doi:10.1016/s0301-0511(02)00113-8

Cited by 74 publications

(37 citation statements)

References 34 publications

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“…However, similar to this study, no disruption of the temporal MMN was observed in schizophrenic patients vs healthy controls in two recent studies using the nose as reference and applying a similar 'roving' paradigm as used in this study (Baldeweg et al, 2004;Sato et al, 2003). In contrast to S-ketamine's lack of effect on temporal MMN, our study found that S-ketamine did disrupt the frontal MMN, which is consistent with previous human studies using different MMN paradigms (Heekeren et al, 2008;Umbricht et al, 2000).…”

Section: S-ketamine-induced Cognitive Impairmentssupporting

confidence: 91%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

100

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Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT 2A R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia. Recent theories of psychosis posit that aberrant encoding of prediction errors (PE) may underlie the expression of psychotic symptoms. This study used a roving mismatch negativity (MMN) paradigm to investigate whether the encoding of PE is affected by pharmacological manipulation of NMDAR or 5-HT 2A R, and whether the encoding of PE under placebo can be used to predict drug-induced symptoms. Using a doubleblind within-subject placebo-controlled design, S-ketamine and psilocybin, respectively, were administrated to two groups of healthy subjects. Psychological alterations were assessed using a revised version of the Altered States of Consciousness (ASC-R) questionnaire. As an index of PE, we computed changes in MMN amplitudes as a function of the number of preceding standards (MMN memory trace effect) during a roving paradigm. S-ketamine, but not psilocybin, disrupted PE processing as expressed by a frontally disrupted MMN memory trace effect. Although both drugs produced positive-like symptoms, the extent of PE processing under placebo only correlated significantly with the severity of cognitive impairments induced by S-ketamine. Our results suggest that the NMDAR, but not the 5-HT 2A R system, is implicated in PE processing during the MMN paradigm, and that aberrant PE signaling may contribute to the formation of cognitive impairments. The assessment of the MMN memory trace in schizophrenia may allow detecting early phases of the illness and might also serve to assess the efficacy of novel pharmacological treatments, in particular of cognitive impairments.

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Section: S-ketamine-induced Cognitive Impairmentssupporting

confidence: 91%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

100

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“…The major part of this MMN deficit is caused by selective attenuation of the frontal MMN component (Baldeweg et al, 2002;Sato et al, 2003;Todd et al, 2003). The loss of adaptive properties of this frontal component (including RP) is correlated robustly with measures of cognitive impairment and social dysfunction in chronic schizophrenia (Baldeweg et al, 2004;Light and Braff, 2005).…”

Section: Neurophysiology Of Auditory Sensory Memorymentioning

confidence: 99%

Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Haenschel

Вернон²,

Dwivedi³

et al. 2005

J. Neurosci.

251

265

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The event-related potential (ERP) component mismatch negativity (MMN) is a neural marker of human echoic memory. MMN is elicited by deviant sounds embedded in a stream of frequent standards, reflecting the deviation from an inferred memory trace of the standard stimulus. The strength of this memory trace is thought to be proportional to the number of repetitions of the standard tone, visible as the progressive enhancement of MMN with number of repetitions (MMN memory-trace effect). However, no direct ERP correlates of the formation of echoic memory traces are currently known. This study set out to investigate changes in ERPs to different numbers of repetitions of standards, delivered in a roving-stimulus paradigm in which the frequency of the standard stimulus changed randomly between stimulus trains. Normal healthy volunteers (n ϭ 40) were engaged in two experimental conditions: during passive listening and while actively discriminating changes in tone frequency. As predicted, MMN increased with increasing number of standards. However, this MMN memory-trace effect was caused mainly by enhancement with stimulus repetition of a slow positive wave from 50 to 250 ms poststimulus in the standard ERP, which is termed here "repetition positivity" (RP). This RP was recorded from frontocentral electrodes when participants were passively listening to or actively discriminating changes in tone frequency. RP may represent a human ERP correlate of rapid and stimulus-specific adaptation, a candidate neuronal mechanism underlying sensory memory formation in the auditory cortex.

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“…More than 30 reports have consistently demonstrated an attenuated MMN amplitude in schizophrenia patients, indicating a deficit in their early pre-attentive change detection system (e.g., Shelley et al 1991;Javitt et al 1993;Michie et al 2000;Baldeweg et al 2002;Sato et al 2003;Todd et al 2003;Bramon et al 2004;Light and Braff 2005;Umbricht and Krljes 2005). Recently, MMN deficits have also been shown to be highly associated with both poor functional status (Light and Braff 2005) and cognitive dysfunction in patients with chronic schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Acute dopamine D1 and D2 receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects

et al. 2007

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Impairment in activation of a frontal attention-switch mechanism in schizophrenic patients

Cited by 74 publications

References 34 publications

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Event-Related Brain Potential Correlates of Human Auditory Sensory Memory-Trace Formation

Acute dopamine D1 and D2 receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects

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