Abstract:ID 24646 Poster Board 20Duloxetine (DLX), a dual serotonin and norepinephrine reuptake inhibitor for the treatment of major depressive disorder, is mainly metabolized by CYP1A2 and CYP2D6 in human. Despite DLX has a good tolerance for most patients, the cases with serious liver injury have been reported. Here, we investigated the roles of P450-mediated metabolism in the DLX hepatotoxicity in vitro and in vivo. We found that DLX is less toxic to CYP1A2-or CYP2D6-overexpressed HepG2 cells compared to their count… Show more
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