Impaired Working Memory in Geriatric Depression: An fMRI Study

Dumas, Julie A.; Newhouse, Paul

doi:10.1016/j.jagp.2014.09.011

Cited by 18 publications

(14 citation statements)

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“…One implication of these findings is that concomitant targeting of reduced motivation may be a more effective means of developing self-regulation of memory impairments in PD. Such an approach could be especially useful in those with depression (Goedeken, Potempa, Prager, & Foster, 2018) given that our findings confirmed that increased depressive symptomatology was associated with impairments of both objective and subjective memory (e.g., Dumas & Newhouse, 2015;Fastame, 2014). However, additional research in this area is needed since prior research indicates that apathy and depression are not correlated in PD (Pluck & Brown, 2002).…”

Section: Discussionmentioning

confidence: 71%

“…While increased clarity concerning the impact of PD on objective and subjective memory and the relationship between them is highly desirable, such a goal is complicated by confounding variance in depressive symptomatology (Dumas & Newhouse, 2015;Fastame, 2014). This is rarely considered in PD samples and, when it has, findings have been mixed (Coutler, 1989;Reynolds, Hanna, Neargarder, & Cronin-Golomb, 2017;Sitek et al, 2011).…”

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confidence: 99%

“…Findings regarding the impact of depression on working memory are similarly mixed. Some studies have found depression to negatively impact performance (Dumas & Newhouse, 2015) while other studies have found no impairment (Reynolds et al, 2017). Overall, systematic studies investigating this topic are lacking and as suggested by Pannu and Kaszniak (2005), the administration of different neuropsychological tools to patients at different disease stages is also likely to contribute to the variability in findings.…”

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confidence: 99%

“…2. Self-reported depression was expected to impact (Dumas & Newhouse, 2015) or have no effect (Reynolds et al, 2017) on forward and backward immediate serial recall of non-demented adults with PD. No specific hypotheses can be proposed about the effect of depressive symptoms on vocabulary, because of the lack of previous evidence.…”

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confidence: 99%

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Memory, subjective memory and motor functioning in non-demented elders with and without Parkinson’s disease

et al. 2019

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Parkinson’s Disease (PD) is a progressive neurological condition characterized by motor and non-motor symptoms impacting life quality. The main aim of the current study was to investigate the effect of PD on objective (i.e., working memory and semantic memory) and subjective memory (i.e., self-reported seriousness of forgetting, mnemonic usage and actual memory efficiency) controlling for the effect of depressive symptomatology. The relationship of working memory performance to gait and mobility indices was also examined, as well as the factors predicting subjective memory were explored. Fifty-four community-dwelling adults (mean age = 72.3 years, SD = 8.8) were recruited in Sardinia, an Italian island located in the Mediterranean Sea. Specifically, 27 non-demented adults with mild, early-stage PD were matched for years of education, age, and gender with a sample of healthy individuals. Participants completed a test battery assessing objective memory, subjective memory, and depressive symptoms, and an instrumental analysis of gait and functional mobility was performed. Participants with PD had poorer objective memory across all indices measured and displayed a restricted set of gait and posture impairments. Working memory performance was selectively related to gait and posture measures. Moreover, participants with PD had lower trust in their memory efficiency relative to the past than the control healthy group. Finally, 22% of the variance in seriousness of the consequences of forgetting was predicted by education and general cognitive efficiency. Overall, the present findings confirm the presence of changes in both objective and subjective memory in PD, independent from depressive symptoms.

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Section: Discussionmentioning

confidence: 71%

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confidence: 99%

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Memory, subjective memory and motor functioning in non-demented elders with and without Parkinson’s disease

et al. 2019

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“…Previous studies have reported aberrant EEG performance, such as increased slow activity in the frontal areas (Grin-Yatsenko et al, 2009 , 2010 ), in depressed patients. Depressed older adults were found to have decreased frontal and parietal activation during some working memory tasks (Dumas and Newhouse, 2015 ). Weakened prefrontal and frontal connections may suggest decreased activation of the cortico-limbic circuit, which is related to symptoms such anhedonia or blunted affect (Fingelkurts and Fingelkurts, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Mutual Information-Based Brain Network Analysis in Post-stroke Patients With Different Levels of Depression

Sun

Yang

Wang

et al. 2018

Front. Hum. Neurosci.

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Post-stroke depression (PSD) is the most common stroke-related emotional disorder, and it severely affects the recovery process. However, more than half cases are not correctly diagnosed. This study was designed to develop a new method to assess PSD using EEG signal to analyze the specificity of PSD patients' brain network. We have 107 subjects attended in this study (72 stabilized stroke survivors and 35 non-depressed healthy subjects). A Hamilton Depression Rating Scale (HDRS) score was determined for all subjects before EEG data collection. According to HDRS score, the 72 patients were divided into 3 groups: post-stroke non-depression (PSND), post-stroke mild depression (PSMD) and post-stroke depression (PSD). Mutual information (MI)-based graph theory was used to analyze brain network connectivity. Statistical analysis of brain network characteristics was made with a threshold of 10–30% of the strongest MIs. The results showed significant weakened interhemispheric connections and lower clustering coefficient in post-stroke depressed patients compared to those in healthy controls. Stroke patients showed a decreasing trend in the connection between the parietal-occipital and the frontal area as the severity of the depression increased. PSD subjects showed abnormal brain network connectivity and network features based on EEG, suggesting that MI-based brain network may have the potential to assess the severity of depression post stroke.

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Consistency, Replication, and Meta-analyses of Altered Brain Activity in Unipolar Depression

Deanna

Pagliaccio

2017

JAMA Psychiatry

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Müller et al1 provide a technically sophisticated and informative set of meta-analyses examining altered brain activity in adults with symptomatic unipolar depression. The striking overall finding of their analyses is the lack of consistent group differences across studies. The absence of replicable effects across studies remained even when they addressed a number of potentially key confounds, such as examining only patients not receiving medication, patients without comorbidities, and patients without late-life or geriatric depression. Furthermore, Müller et al 1 make a number of important suggestions for conducting high-quality metaanalyses in the future that can be replicated and that can provide guidance for future research in the field. These excellent suggestions include the use of a reasonably large number of experiments with homogenous methods, avoiding region-ofinterest or restricted analysis studies that may bias results, only including studies with a sufficiently stringent false-positive correction, and providing sufficient details about the methods to allow replication. The inconsistency of prior results examining altered brain activity in unipolar depression revealed by Müller et al 1 should definitely give the field pause and highlights the need to address underlying causes of this lack of replication. However, some of these findings need to be interpreted with caution because Müller et al 1 do not fully follow their own recommendations, particularly regarding combining across homogenous methods. Specifically, the meta-analysis of cognitive tasks combined across paradigms that varied considerably in processing demands, and it is not clear that one would predict common regions to show altered activity in unipolar depression across quite different cognitive domains. This concern extends even to the meta-analysis of memory processing because this particular meta-analysis combined studies examining either working memory or episodic memory. Although some brain regions contribute to both working memory and episodic memory, there is also strong evidence for dissociations in the neural systems underlying working vs episodic memory and even for dissociations among subcomponents of episodic memory. Thus, to the extent that unipolar depression is associated with greater impairments in some components of memory than others, 2 one would not expect there to be consistent alterations in brain activation across all these different types of studies. and psychiatric comorbidity, which are both important dimensions of variance. However, it is also important to account for variance in symptom presentation among individuals with unipolar depression, even among individuals without comorbid conditions. For example, individuals with depression vary in the degree to which their clinical presentation is associated with alterations in mood or hedonic function, or both. Interestingly, some research is now starting to suggest that negative mood and impaired hedonic capacity may relate to different types of emotion processing im...

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Impaired Working Memory in Geriatric Depression: An fMRI Study

Abstract: Cognitive dysfunction in geriatric depression may be related to reorganization of brain networks involved in working memory.

Cited by 18 publications

References 10 publications

Memory, subjective memory and motor functioning in non-demented elders with and without Parkinson’s disease

Memory, subjective memory and motor functioning in non-demented elders with and without Parkinson’s disease

Mutual Information-Based Brain Network Analysis in Post-stroke Patients With Different Levels of Depression

Consistency, Replication, and Meta-analyses of Altered Brain Activity in Unipolar Depression

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