Impaired water maze navigation of Wistar rats with retrosplenial cortex lesions: effect of nonspatial pretraining

Lukoyanov, Nikolay; Lukoyanova, Elena A.; Andrade, José Paulo; Paula‐Barbosa, M. M.

doi:10.1016/j.bbr.2004.08.023

Cited by 31 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lesions to retrosplenial cortex (area 29) in rodents disrupts spatial navigation and maze learning (Harker and Whishaw, 2004;Lukoyanov et al, 2005). Although we examined only the responses of cells presumed to lie in areas 23 and 31 of cingulate cortex and not the closely connected areas 29 and 30, disruptions in topographic spatial orientation after retrosplenial lesions are consistent with the allocentric bias in visuospatial representations uncovered in our study.…”

Section: Spatial Deficits After Lesions Of Posterior Cingulate Cortexsupporting

confidence: 63%

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Dean¹,

Platt²

2006

J. Neurosci.

View full text Add to dashboard Cite

Section: Spatial Deficits After Lesions Of Posterior Cingulate Cortexsupporting

confidence: 63%

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Dean¹,

Platt²

2006

J. Neurosci.

View full text Add to dashboard Cite

“…Conversely, the RS group could acquire P2-P4 as fast as the Cont group. Previous studies reported that RS-lesioned rats that had preoperative training showed mild impairment compared with those without preoperative training (Lukoyanov et al 2005;Cain et al 2006). Thus, since in the present experiment we conducted preoperative training using different alternatives, RS-lesioned rats might have been able to perform normally in postoperative place discrimination training.…”

Section: Figure 2 Behavioral and Histological Results Of The Retrogrmentioning

confidence: 84%

Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

Haijima¹,

Ichitani²

2008

Learn. Mem.

View full text Add to dashboard Cite

Retrograde and anterograde amnesic effects of excitotoxic lesions of the rat retrosplenial cortex (RS) and hippocampus (HPC) were investigated. To test retrograde amnesia, rats were trained with two-arm place discrimination in a radial maze 4 wk and 1 d before surgery with a different arm pair, respectively. In the retention test 1 wk after surgery, both lesion groups showed temporally ungraded retrograde amnesia. To test anterograde amnesia, animals were trained after surgery to discriminate three arm pairs successively within a day, and then after interposition of 1-to 4-wk intervals, one of these pairs, respectively, was tested for retention. RS-lesioned rats could acquire these pairs of place discriminations rapidly but showed a retention interval-dependent impairment in the retention test. Conversely, HPC-lesioned rats took more sessions to acquire these pairs than did the control group, and their retention was ∼70% of correct performance regardless of retention interval. Results suggest that RS and HPC have different roles in spatial memory and that RS is important for remote memory process.Recent studies indicate that the retrosplenial cortex (RS) may contribute to spatial learning and memory in humans (Valenstein et al. 1987;Maguire 2001) and rodents (Sutherland et al. 1988; Aggleton 2002, 2004). In addition, the RS might cooperate with the hippocampus (HPC) to engage in spatial learning and memory, since the RS has dense reciprocal neural connections with the hippocampal formation (Vogt 1986;Wyss and van Goren 1992;Burwell and Amaral 1998), which is important for learning and memory, and both RS and HPC contain neurons with spatial firing properties such as "head direction cells" (Chen et al. 1994;Cho and Sharp 2001) and "place cells" (O'Keefe and Nadel 1978). Furthermore, the neural activity of RS affects the hippocampal spatial coding (Cooper and Mizumori 2001) and the hippocampal theta wave activity (Destrade and Ott 1982;Vanderwolf et al. 1985), which is related to learning and memory (Pan and McNaughton 1997). Moreover, fornix transection or HPC lesions caused a reduction of c-Fos expression in RS during radial maze performance (Vann et al. 2000;Albasser et al. 2007).It has been considered that memory function depends on an interaction between HPC and the neocortical areas (e.g., Squire 1992; Eichenbaum et al. 1994;Nadel and Moscovitch 1997). Most of these perspectives assumed that long-term memory is stored in the neocortex. Thus, the RS might be one of the candidate brain regions that form a network with hippocampal formation in memory function, especially in long-term memory processing. However, there were few lesion studies that demonstrated the role of the RS in spatial memory processes and that directly compared the effects of lesions of the RS and HPC. Thus, it remains unclear whether the RS is important for spatial longterm memory and whether the roles of the RS and HPC in spatial memory could be clearly differentiated.Here we compared retrograde and anterograde amnesic effects of RS and HP...

show abstract

“…For example, in the Morris water maze, the location of an invisible submerged platform is not indicated by an individual cue, but rather by the configuration of multiple visual cues present in the surrounding environment. Like contextual fear conditioning, there is substantial evidence that damage to RSC, in the form of permanent lesions or temporary inactivation, impairs performance on a variety of spatial navigation tasks (Cain et al, 2006; Cooper & Mizumori, 1999; Cooper et al, 2001; Harker & Whishaw, 2002, 2004; Lukoyanov et al, 2005; Pothuizen et al, 2010; van Groen et al, 2004; Vann & Aggleton, 2002, 2004; Vann et al, 2003), although the effects may vary based on lesion methods and extent of damage to surrounding areas such as the cingulum bundle. Damage to RSC also produces deficits in spatial working memory, in which a new location is learned during each set of trials (Keene & Bucci, 2009).…”

Section: Similarities Between Rsc and Por/phc: Anatomical And Behamentioning

confidence: 99%

Toward a conceptualization of retrohippocampal contributions to learning and memory

Bucci

Robinson

2014

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

A wealth of data supports the notion that the hippocampus binds objects and events together in place and time. In support of this function, a cortical circuit that includes the retrosplenial cortex (RSC) and various structures in the parahippocampal region is thought to provide the hippocampus with essential information regarding the physical and temporal context in which the object/event occurs. However, it remains unclear if and how individual components of this so-called ‘where’ circuit make unique contributions to processing context-related information. Here we focus on the RSC and the postrhinal cortex (POR; homologous with parahippocampal cortex (PHC) in primates), two of the most strongly interconnected components of the where pathway and the foci of an increasing amount of recent research. Much of the behavioral evidence to date suggests that RSC and POR/PHC work closely together as a functional unit. We begin by briefly reviewing studies that have investigated the involvement of RSC and POR/PHC in contextual and spatial learning, both of which involve learning associations and relationships between the individual stimuli that compose an environment (i.e., where information). However, we propose that potential differences have been overlooked because most studies to date have relied on behavioral paradigms and experimental approaches that are not well suited for distinguishing between different aspects of information processing. We then consider the anatomical differences between RSC and POR/PHC and emerging behavioral evidence that gives rise to a working model of how these regions may differentially contribute to hippocampal-dependent learning and memory. We then discuss experimental designs and behavioral methods that may be useful in testing the model. Finally, approaches are described that may be valuable in probing the nature of information processing and neuroplasticity in the myriad of local circuits that are nested within the where pathway.

show abstract

Impaired water maze navigation of Wistar rats with retrosplenial cortex lesions: effect of nonspatial pretraining

Cited by 31 publications

References 29 publications

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Allocentric Spatial Referencing of Neuronal Activity in Macaque Posterior Cingulate Cortex

Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats

Toward a conceptualization of retrohippocampal contributions to learning and memory

Contact Info

Product

Resources

About