Impaired Vitamin D Metabolism in CKD

Bosworth, Cortney; Boer, Ian H. de

doi:10.1016/j.semnephrol.2012.12.016

Cited by 81 publications

(67 citation statements)

References 140 publications

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“…Thus, the level of 25(OH)D could paradoxically be higher among people with early stages of CKD than among those with adequate eGFR (11). The 1,25(OH) 2 D deficiency in CKD could be mediated via fibroblast growth factor-23 (FGF-23), a protein that is elevated in CKD and inhibits the conversions of 25(OH)D into 1,25(OH) 2 D and stimulates the catabolism of 1,25(OH) 2 D (12,13).…”

Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Guessous

McClellan

Kleinbaum

et al. 2015

Clinical Journal of the American Society of Nephrology

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Background and objectives Molecular evidence suggests that levels of vitamin D are associated with kidney function loss. Still, population-based studies are limited and few have considered the potential confounding effect of baseline kidney function. This study evaluated the association of serum 25-hydroxyvitamin D with change in eGFR, rapid eGFR decline, and incidence of CKD and albuminuria.Design, setting, participants, & measurements Baseline (2003Baseline ( -2006 and 5.5-year follow-up data from a Swiss adult general population were used to evaluate the association of serum 25-hydroxyvitamin D with change in eGFR, rapid eGFR decline (annual loss .3 ml/min per 1.73 m 2 ), and incidence of CKD and albuminuria. Serum 25-hydroxyvitamin D was measured at baseline using liquid chromatography-tandem mass spectrometry. eGFR and albuminuria were collected at baseline and follow-up. Multivariate linear and logistic regression models were used considering potential confounding factors.Results Among the 4280 people included in the analysis, the mean6SD annual eGFR change was 20.5761.78 ml/min per 1.73 m 2 , and 287 (6.7%) participants presented rapid eGFR decline. Before adjustment for baseline eGFR, baseline 25-hydroxyvitamin D level was associated with both mean annual eGFR change and risk of rapid eGFR decline, independently of baseline albuminuria. Once adjusted for baseline eGFR, associations were no longer significant. For every 10 ng/ml higher baseline 25-hydroxyvitamin D, the adjusted mean annual eGFR change was 20.005 ml/min per 1.73 m 2 (95% confidence interval, 20.063 to 0.053; P=0.87) and the risk of rapid eGFR decline was null (odds ratio, 0.93; 95% confidence interval, 0.79 to 1.08; P=0.33). Baseline 25-hydroxyvitamin D level was not associated with incidence of CKD or albuminuria.Conclusions The association of 25-hydroxyvitamin D with eGFR decline is confounded by baseline eGFR. Sufficient 25-hydroxyvitamin D levels do not seem to protect from eGFR decline independently from baseline eGFR.

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Section: Introductionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Guessous

McClellan

Kleinbaum

et al. 2015

Clinical Journal of the American Society of Nephrology

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“…Al is the only component listed in vaccine package inserts known to have a toxicokinetic profile modulated by parathyroid hormone activity. The causal cascade of aluminum toxicity in chronic kidney disease [157,158] would differ from sun deprivation only in that diseased proximal renal tubule cells are not able to convert 25(OH)D3 to 1,25(OH)2D3 [159,160].…”

Section: Mechanism Of Impaired Excretion Of Aluminummentioning

confidence: 99%

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

CA¹

2013

Immunome Res

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Multisystem interactions are well established in neurological disorders, in spite of conventional views that only the central nervous system (CNS) is impacted. We review evidence for mutual interactions between the immune and nervous systems and show how these seem to be implicated in the origin and progression of nervous system disorders. Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known neurotoxicant, may be of particular importance. We have demonstrated elsewhere that aluminum has the potential to induce damage at a range of levels in the CNS leading to neuronal death, circuit malfunction and ultimately, system failure. Aluminum is widely used as an adjuvant in various vaccine formulations and has been implicated in a multisystem disorder termed "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). The implications of aluminum-induced ASIA in some disorders of the CNS are considered. We propose a unified theory capturing a progression from a local response to a systemic response initiated by disruption of water-based interfaces of exposed cells.

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“…A sufficient supply of native vitamin D (25(OH) D) in the form of ergocalciferol (vitamin D2) or cholecalciferol (vitamin D3) is required for its synthesis in the kidney's proximal convoluted tubule 1-3. …”

Section: Introductionmentioning

confidence: 99%

Vitamin D (25 ( OH) D ) in patients with chronic kidney disease stages 2-5

Valencia

Arango

2019

Colomb Med

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This corrects the article "Vitamin D (25 ( OH) D ) in patients with chronic kidney disease stages 2-5" in volume 47(3) on page 163, Table 3. The September 30, 2016, article by Restrepo and Aguirre (Colomb Med (Cali). 2016;47(3): 160-6, was published with errors in Table 3. In body of Table 3, the sixth line of the first column entitled PH (pg/mL), this should read: PTHi (pg/mL). The sixth line of the eight column reads: 11.65, this should read: 116.5. That date appears well in the English XML version, but in both the PDF ingles and the Spanish version appears the value 11.65, must be changed to the real value: 116.5.

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Impaired Vitamin D Metabolism in CKD

Cited by 81 publications

References 140 publications

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Serum 25-Hydroxyvitamin D Level and Kidney Function Decline in a Swiss General Adult Population

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

Vitamin D (25 ( OH) D ) in patients with chronic kidney disease stages 2-5

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