Impaired verbal source monitoring in schizophrenia: An intermediate trait vulnerability marker?

Brunelin, Jérôme; d’Amato, Thierry; Brun, P; Bediou, Benoît; Kallel, Lassad; Senn, Muriel; Poulet, Emmanuel; Saoud, Mohamed

doi:10.1016/j.schres.2006.08.028

Cited by 59 publications

(55 citation statements)

References 32 publications

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“…In turn we may suggest that adolescent failing to evaluate internally self-generated information would also tend to express more important levels of schizotypy. This interpretation would be consistent with the accumulated evidence showing impaired recalling self-generated information in psychosis-prone and schizophrenic adults (Brunelin et al, 2007;Larøi et al, 2005).…”

Section: Discussionsupporting

confidence: 90%

Neural correlates of reality monitoring during adolescence

Lagioia¹,

Eliez²,

Schneider³

et al. 2011

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Much like adults performing a similar reality monitoring task, adolescents exhibit a common pattern of brain activity during origin and context monitoring, with functional specialization within the prefrontal cortex involving preferential activation of BA 10 during origin monitoring. Greater schizotypal trait expression appears to be significantly associated to reduced BA 10 activity during origin monitoring trials. Results are discussed in relation to cortical specialization within the PFC and trait expression during adolescence.

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Section: Discussionsupporting

confidence: 90%

Neural correlates of reality monitoring during adolescence

Lagioia¹,

Eliez²,

Schneider³

et al. 2011

NeuroImage

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“…Practice effects are unlikely to account for this improvement, as a study in controls demonstrated stable performance on the paradigm over three months [18], and our follow-up period was significantly longer. An improvement in VSM performance in participants whose mental state has improved is consistent with cross-sectional evidence that VSM performance is worse in acutely psychotic than remitted patients with schizophrenia [19], and contrasts with evidence that VSM performance is related to a trait vulnerability to psychosis, with impairments evident in patients' non-psychotic siblings [3]. In contrast, mean beads task performance remained stable over time.…”

Section: Discussionsupporting

confidence: 70%

Misattributing speech and jumping to conclusions: A longitudinal study in people at high risk of psychosis

et al. 2015

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Biases in cognition such as Jumping to Conclusions (JTC) and Verbal Self-Monitoring (VSM) are thought to underlie the formation of psychotic symptoms. This prospective study in people with an At Risk Mental State (ARMS) for psychosis examined how these cognitive biases changed over time, and predicted clinical and functional outcomes. Twenty-three participants were assessed at clinical presentation and a mean of 31 months later. Performance on a JTC and VSM tasks were measured at both time points. Relationships to symptom severity, level of function and the incidence of psychotic disorder were then examined. The levels of symptoms, function and VSM all improved over time, while JTC was stable. Five participants (22%) developed a psychotic disorder during the follow-up period, but the risk of transition was not related to performance on either task at baseline, or to longitudinal changes in task performance. JTC performance correlated with symptom severity at baseline and follow-up. Similarly, performance on the two tasks was not related to the level of functioning at follow-up. Thus, while the ARMS is associated with both VSM and JTC biases, neither predict the onset of psychosis or the overall functional outcome.

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“…Indeed a study by [7] found that when examining patients with SZ, their siblings, and healthy controls, emotion recognition performance was distributed along a continuum between the control group and the schizophrenia group, with the siblings group midway between. This continuum parallels the one observed in cognition [11,56,60]. This same study by Bediou et al also demonstrates that, much like cognition, emotion recognition deficits are apparent prior to illness onset and before treatment and that performance remained impaired after 1 month of low-dose haloperidol treatment despite symptom stabilisation, suggesting trait-like features.…”

Section: Introductionsupporting

confidence: 76%