Impaired urinary acidification in the hypothyroid rat

Michael, Ulrich F.; Chavez, Rafaelita; Cookson, S. L.; Vaamonde, Carlos A.

doi:10.1007/bf00587285

Cited by 13 publications

(6 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, dRTA was also reported in non-autoimmune hypothyroidism ( 12 ). Likewise, a defect in the renal acidification was observed in hypothyroid rats ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome

et al. 2016

View full text Add to dashboard Cite

Introduction:Hypothyroidism has been reported to affect renal function and structure. However, the association of hypothyroidism with distal renal tubular acidosis (dRTA) is rarely reported in children.Case Presentation:We present a 6-year-boy with Down syndrome admitted in our department due to vomiting, weakness, polyuria, polydipsia, irritability and weight loss in the last few weeks. Investigations revealed features of hypokalemia, metabolic acidosis and alkaline urine consistent with dTRA. Abdominal ultrasound found nephrocalcinosis. In addition, Antithyroid peroxidase antibodies were positive, suggesting an autoimmune background for the pathogenesis of the tubular dysfunction. Treatment for dRTA and hypothyroidism was started and symptomatic improve was noticed.Conclusion:dRTA should be excluded in children with autoimmune disorders who develop weakness, polyuria, polydipsia or growth failure. Early diagnosis would reduce long-term complications.

show abstract

“…On the other hand, dRTA was also reported in non-autoimmune hypothyroidism ( 12 ). Likewise, a defect in the renal acidification was observed in hypothyroid rats ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A number of acquired states are associated with dysregulation of collecting duct acid-base transport and can be caused by a variety of diseases such autoimmune disease (Sjögren's disease, autoimmune hypothyrodism), isolated 25 hypothyroidism (114,127,219), or hypoaldosteronism. Moreover, a number of drugs may impair the collecting ducts ability to excrete acid or to adapt appropriately to altered systemic acid-base status.…”

Section: Acquired Problems Of Collecting Duct Acid-base Transportmentioning

confidence: 99%

Regulated acid–base transport in the collecting duct

Wagner

Devuyst

Bourgeois

et al. 2009

Pflugers Arch - Eur J Physiol

161

142

View full text Add to dashboard Cite

The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type-A intercalated cells secrete protons via a luminally expressed V-type H(+)-ATPase and generate new bicarbonate released by basolateral chloride/bicarbonate exchangers including the AE1 anion exchanger. Efficient proton secretion depends both on the presence of titratable acids (mainly phosphate) and the concomitant secretion of ammonia being titrated to ammonium. Collecting duct ammonium excretion requires the Rhesus protein RhCG as indicated by recent KO studies. Urinary acid secretion by type-A intercalated cells is strongly regulated by various factors among them acid-base status, angiotensin II and aldosterone, and the Calcium-sensing receptor. Moreover, urinary acidification by H(+)-ATPases is modulated indirectly by the activity of the epithelial sodium channel ENaC. Bicarbonate secretion is achieved by non-type-A intercalated cells characterized by the luminal expression of the chloride/bicarbonate exchanger pendrin. Pendrin activity is driven by H(+)-ATPases and may serve both bicarbonate excretion and chloride reabsorption. The activity and expression of pendrin is regulated by different factors including acid-base status, chloride delivery, and angiotensin II and may play a role in NaCl retention and blood pressure regulation. Finally, the relative abundance of type-A and non-type-A intercalated cells may be tightly regulated. Dysregulation of intercalated cell function or abundance causes various syndromes of distal renal tubular acidosis underlining the importance of these processes for acid-base homeostasis.

show abstract

“…Renal tubular acidosis is defined as an inability of the renal tubule to acidify urine, which is out of proportion to any reduction in the glomerular filtration rate. The acidification defect has been described to be mild and presumably related to thyroxine defiency 7,8 . An autoimmune mechanism has also been suggested to cause renal tubular acidosis in hypothyroid disorder 9,10 .…”

Section: Discussionmentioning

confidence: 99%

Hypokalaemic Periodic Paralysis Associated with Hypothyroidism

Joy¹,

Singh²,

Sangme³

2012

Indian Journal of Physical Medicine and Rehabilitation

View full text Add to dashboard Cite

Periodic paralysis is also seen as one of the uncommon cause of quadriplegia in the physical and rehabilitation medicine practice. There have been anecdotal reports of periodic paralysis associated with hypothyroidism. However, there is no clear cut evidence of hypothyroidism causing hypokalaemia leading to periodic paralysis or vice versa. This case report highlights the importance of keeping periodic paralysis as an important cause of the recurrent paralytic attack, importance of serum potassium and thyroid function tests and recovery pattern without active physical therapy intervention which may actually aggravate the disease process. Its occurrence in a young male patient is also a rare phenomenon.

show abstract

Impaired urinary acidification in the hypothyroid rat

Cited by 13 publications

References 19 publications

Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome

Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome

Regulated acid–base transport in the collecting duct

Hypokalaemic Periodic Paralysis Associated with Hypothyroidism

Contact Info

Product

Resources

About