Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function

Weder, Bruno; Leenders, Klaus L.; Vontobel, Peter; Nienhusmeier, Matthias; Keel, Andrew; Zaunbauer, Wolfgang; Vonesch, T.; Ludin, H. P.

doi:10.1002/(sici)1097-0193(1999)8:1<1::aid-hbm1>3.0.co;2-e

Cited by 38 publications

(25 citation statements)

References 52 publications

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“…Thus, our results predict that patients with dysfunctional basal ganglia and cerebellum should not only be impaired in temporal tasks but also in tasks involving spatial judgements (Gao et al, 1996;Weder et al, 1999;Bara-Jimenez et al, 2000;Molloy et al, 2003). Basal ganglia and cerebellar lesions could exert a more specific effect on timing function by disrupting their input to frontal cortex.…”

Section: Relationship To Lesion Studiesmentioning

confidence: 67%

The Functional Neuroanatomy of Temporal Discrimination

Pastor¹,

Day²,

Macaluso³

et al. 2004

J. Neurosci.

181

119

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Two identical stimuli, such as a pair of electrical shocks to the skin, are readily perceived as two separate events in time provided the interval between them is sufficiently long. However, as they are presented progressively closer together, there comes a point when the two separate stimuli are perceived as a single stimulus. Damage to posterior parietal cortex, peri-supplementary motor area (peri-SMA), and basal ganglia can disturb this form of temporal discrimination. Our aim was to establish, in healthy subjects, the brain areas that are involved in this process. During functional magnetic resonance imaging scanning, paired electrical pulses, separated by variable interstimulus intervals (5-110 msec), were delivered to different sites on one forearm (8 -64 mm from the midline). Subjects were required to simply detect the stimulus (control task) or to identify a stimulus property. For temporal discrimination (TD), subjects reported whether they felt one or two stimuli. For spatial discrimination, they reported whether the stimuli were located on the right or left side of the forearm. Subjects reported their choice by pressing a button with the opposite hand. Our results showed that discrimination, as opposed to simply detection, activated several brain areas. Most were common to both discrimination tasks. These included regions of prefrontal cortex, right postcentral gyrus and inferior parietal lobule, basal ganglia, and cerebellum. However, activation of pre-SMA and anterior cingulate was found to be specific to the TD task. This suggests that these two frontal regions may play a role in the temporal processing of somatosensory events.

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Section: Relationship To Lesion Studiesmentioning

confidence: 67%

The Functional Neuroanatomy of Temporal Discrimination

Pastor¹,

Day²,

Macaluso³

et al. 2004

J. Neurosci.

181

119

View full text Add to dashboard Cite

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“…Thus, in a PET study of dopamine transporters, binding in the caudate nucleus correlated inversely with sequence learning in PD patients (Carbon et al, 2004). In earlier FDOPA/PET studies, k 3 s in the caudate of PD patients correlated inversely with performance of a memory task (Holthoff-Detto et al, 1997), somatosensory discrimination (Weder et al, 1999), and the Stroop interference task (Rinne et al, 2000;Brü ck et al, 2001). We now use quantitative parametric methods to reveal an increased elimination rate constant for [ 18 F]fluorodopamine in the most affected caudate nucleus of patients with early PD, predicting that cognitive processes may be influenced by asymmetric changes in dopamine turnover.…”

Section: Discussionmentioning

confidence: 87%

Dopamine Storage Capacity in Caudate and Putamen of Patients with Early Parkinson's Disease: Correlation with Asymmetry of Motor Symptoms

Kumakura

Gjedde

Danielsen

et al. 2005

J Cereb Blood Flow Metab

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Conventional graphical analysis of positron emission tomography (PET) recordings of the cerebral uptake of the DOPA decarboxylase substrate [ 18 F]fluorodopa (FDOPA) assumes irreversible trapping of [ 18 F]fluorodopamine formed in the brain. However, 4-h long PET recordings allow the estimation of a rate constant for elimination of [ 18 F]fluorodopamine from the brain (k loss ), from which can be calculated an effective distribution volume (EDV 1 ), which is an index of [ 18 F]fluorodopamine storage capacity. We earlier developed a method employing 2-h long FDOPA recordings for the estimation of k loss and EDV, here defined as EDV 2 . This method is based on subtraction of the calculated brain concentrations of the FDOPA metabolite O-methyl-FDOPA, rather than the subtraction of the entire radioactivity in a reference region. We now extend this method for the parametric mapping of these parameters in the brain of healthy aged volunteers and patients with Parkinson's disease (PD), with asymmetry of motor symptoms. For parametric mapping, we use a novel application of a multilinear solution for the two-tissue compartment FDOPA model. We also test a new application of the Logan graphical analysis for mapping of the FDOPA distribution volume at equilibrium. The estimates of k loss and EDV 2 were more sensitive for the discrimination of biochemical abnormality in the putamen of patients with early PD relative to healthy aged subjects, than was the conventional net influx estimate. Of the several methods, multilinear estimates of EDV 2 were most sensitive for discrimination of PD and normal putamen. However, k loss was most sensitive for detecting biochemical asymmetry in the putamen of PD patients, and only k loss also detected in the caudate of PD patients a decline in the retention of [ 18 F]fluorodopamine relative to healthy aged control subjects.

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“…Available evidence suggests that, apart from the above cortical circuits, subcortical structures are also likely involved in determining attentional control, notably the BG (but also the superior colliculus and parts of the thalamus; e.g., see McNab & Klingberg, 2008;Grande et al, 2006;Muller, Philiastides, & Newsome, 2005;Weder et al, 1999). This may appear rather obvious, given the widespread interconnections linking the BG with vast sectors of the cortical mantle, including the aforementioned prefrontal and frontoparietal regions, and in line with the notion that the BG are part of articulated and diverse cortico-subcortical loops, which are involved in the control of motor, emotional, and cognitive processes ( Yelnik, 2008;Mink, 1996;Parent & Hazrati, 1995;Alexander, DeLong, & Strick, 1986).…”

Section: Introductionmentioning

confidence: 79%

Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease

Tommasi

Fiorio

Yelnik

et al. 2015

Journal of Cognitive Neuroscience

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Abstract■ It is solidly established that top-down (goal-driven) and bottom-up (stimulus-driven) attention mechanisms depend on distributed cortical networks, including prefrontal and frontoparietal regions. On the other hand, it is less clear whether the BG also contribute to one or the other of these mechanisms, or to both. The current study was principally undertaken to clarify this issue. Parkinson disease (PD), a neurodegenerative disorder primarily affecting the BG, has proven to be an effective model for investigating the contribution of the BG to different brain functions; therefore, we set out to investigate deficits of top-down and bottom-up attention in a selected cohort of PD patients. With this objective in mind, we compared the performance on three computerized tasks of two groups of 12 parkinsonian patients (assessed without any treatment), one otherwise pharmacologically treated and the other also surgically treated, with that of a group of controls. The main behavioral tool for our study was an attentional capture task, which enabled us to tap the competition between top-down and bottom-up mechanisms of visual attention. This task was suitably combined with a choice RT and a simple RT task to isolate any specific deficit of attention from deficits in motor response selection and initiation. In the two groups of patients, we found an equivalent increase of attentional capture but also comparable delays in target selection in the absence of any salient distractor (reflecting impaired top-down mechanisms) and movement initiation compared with controls. In contrast, motor response selection processes appeared to be prolonged only in the operated patients. Our results confirm that the BG are involved in both motor and cognitive domains. Specifically, damage to the BG, as it occurs in PD, leads to a distinct deficit of top-down control of visual attention, and this can account, albeit indirectly, for the enhancement of attentional capture, reflecting weakened ability of top-down mechanisms to antagonize bottom-up control. ■

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Impaired somatosensory discrimination of shape in Parkinson's disease: Association with caudate nucleus dopaminergic function

Cited by 38 publications

References 52 publications

The Functional Neuroanatomy of Temporal Discrimination

The Functional Neuroanatomy of Temporal Discrimination

Dopamine Storage Capacity in Caudate and Putamen of Patients with Early Parkinson's Disease: Correlation with Asymmetry of Motor Symptoms

Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease

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