Impaired skeletal health and neuromuscular function among amphetamine users in clinical treatment

Mosti, Mats Peder; Flemmen, Grete; Hoff, Jan; Stunes, Astrid Kamilla; Syversen, Unni; Wang, Eivind

doi:10.1007/s00198-015-3371-z

Cited by 14 publications

(10 citation statements)

References 45 publications

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“…Imbalance of phosphoric acid levels might lead to negative consequences. For example, cannabis smoke and amphetamine exposure might lead to negative effects on teeth and bone mass, respectively [50,51]. Malonic acid plays a key role in the biosynthesis of fatty acids [52,53].…”

Section: Discussionmentioning

confidence: 99%

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder

et al. 2022

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Studies have demonstrated that chronic consumption of abused drugs induces alterations in several proteins that regulate metabolism. For instance, methamphetamine exposure reduces glucose levels. Fatty and amino acid levels were altered in groups exposed to abused drugs. Therefore, in our study, we investigated the serum metabolomic profile of patients diagnosed with cannabis and/or amphetamine use disorders. Blood was obtained from subjects (control, amphetamine, and cannabis). Detection of serum metabolites was performed using gas chromatography. The ratio peak areas for metabolites were analyzed across the three groups. Both cannabis and amphetamine groups showed higher d-erythrotetrafuranose, octadecanoic acid, hexadecenoic acid, trans-9-octadecanoic acid, lactic acid and methyl thio hydantoin metabolites compared with the control group. Moreover, cannabis patients were found to possess higher glycine, 9,12 octadecanoic acid malonic acid, phosphoric acid and prostaglandin F1a than controls. Our analysis showed that the identified metabolic profile of cannabis or amphetamine use disorder patients was different than control group. Our data indicated that chronic exposure to cannabis or amphetamine dysregulated metabolites in the serum. Future studies are warranted to explore the effects of these abused drugs on the metabolic proteins.

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Section: Discussionmentioning

confidence: 99%

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder

et al. 2022

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“…Also, it is now known that diabetes mellitus can induce osteoarthritis and bone fragility due to such factors as low bone turnover, accumulation of advanced glycation endproducts, oxidative stress, inflammation, and adipokine alterations, among others (Courties & Sellam, ; Napoli et al, ). Furthermore, other diseases, behaviors and factors, such as alcoholism (González‐Reimers et al, ), HIV (Finnerty, Walker‐Bone, & Tariq, ), low physical activity (Brennan et al, ), sun exposure deprivation (Gamache & Burge, ; Mosti et al, ), and sleep quality (Sasaki et al, ), among others, compromise bone metabolism which can result in accelerated bone loss. Therefore, the aspect of any osseous biomarker to reflect the biological state of an individual's age might also be reflecting the influence of many different factors, either external or internal, that could be mirroring an aspect of the aging process, which is its rate of change.…”

Section: Discussionmentioning

confidence: 99%

Differences between biological and chronological age‐at‐death in human skeletal remains: A change of perspective

Couoh

2017

American J Phys Anthropol

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TCA can be used to estimate CA and its differences with BA, being less than 10 years, are similar to those found in living populations. Differences between CA and BA are due to intra-population variability, which could be the consequence of individual differences in aging. More research is needed to have confidence that under- and overestimations of BA are indicators of aging variability at the level of the individual.

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“…Amphetamines are classified as indirect sympathomimetic agents that inhibit presynaptic catecholamine reuptake and activate peripheral ␤-adrenergic receptors. Although it reduces fracture risk in young patients diagnosed with ADHD, the use of stimulant medication in the adult population is associated with lower BMD (149,159,215). From these observations and the fact that stimulants preferentially affect trabecular bone, like ␤AR agonists, it can be speculated that amphetamine use in adults augments the level NE in bone in a way that is not efficiently buffered by any of the homeostatic mechanisms reducing NE levels or activity, whereas in children, drug effect on behavior is dominant over effect on the growing skeleton to protect from fracture.…”

Section: G Attention-deficit/hyperactivity Disordermentioning

confidence: 99%

Impact of the Autonomic Nervous System on the Skeleton

Elefteriou

2018

Physiological Reviews

153

170

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It is from the discovery of leptin and the central nervous system as a regulator of bone remodeling that the presence of autonomic nerves within the skeleton transitioned from a mere histological observation to the mechanism whereby neurons of the central nervous system communicate with cells of the bone microenvironment and regulate bone homeostasis. This shift in paradigm sparked new preclinical and clinical investigations aimed at defining the contribution of sympathetic, parasympathetic, and sensory nerves to the process of bone development, bone mass accrual, bone remodeling, and cancer metastasis. The aim of this article is to review the data that led to the current understanding of the interactions between the autonomic and skeletal systems and to present a critical appraisal of the literature, bringing forth a schema that can put into physiological and clinical context the main genetic and pharmacological observations pointing to the existence of an autonomic control of skeletal homeostasis. The different types of nerves found in the skeleton, their functional interactions with bone cells, their impact on bone development, bone mass accrual and remodeling, and the possible clinical or pathophysiological relevance of these findings are discussed.

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Impaired skeletal health and neuromuscular function among amphetamine users in clinical treatment

Cited by 14 publications

References 45 publications

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder

Serum Metabolomic Analysis of Male Patients with Cannabis or Amphetamine Use Disorder

Differences between biological and chronological age‐at‐death in human skeletal remains: A change of perspective

Impact of the Autonomic Nervous System on the Skeleton

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