Impaired retinal microcirculation in multiple sclerosis

Jiang, Hong; Delgado, Silvia; Tan, Jia; Liu, Che; Rammohan, Kottil; DeBuc, Delia Cabrera; Lam, Byron L.; Feuer, William J.; Wang, Jianhua

doi:10.1177/1352458516631035

Cited by 51 publications

(66 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 The apparatus has been described in detail in a previous publication. Hemoglobin was used as a natural, high-contrast chromophore (wavelengths between 530 and 590 nm) to track the erythrocyte moving.…”

Section: Methodsmentioning

confidence: 99%

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Wei

Jiang

Shi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

130

126

View full text Add to dashboard Cite

PurposeTo characterize age-related alterations in the retinal microcirculation, microvascular network, and microstructure in healthy subjects.MethodsSeventy-four healthy subjects aged from 18 to 82 years were recruited and divided into four age groups (G1 with age <35 years, G2 with age 35 ∼ 49 years, G3 with age 50 ∼ 64 years, and G4 with age ≥65 years). Custom ultra-high resolution optical coherence tomography (UHR-OCT) was used to acquire six intraretinal layers of the macula. OCT angiography (OCTA) was used to image the retinal microvascular network. The retinal blood flow velocity (BFV) was measured using a Retinal Function Imager (RFI).ResultsCompared to G1, G2 had significant thinning of the retinal nerve fiber layer (RNFL) (P < 0.05), while G3 had thinning of the RNFL and ganglion cell and inner plexiform layer (GCIPL) (P < 0.05), in addition to thickening of the outer plexiform layer (OPL) and photoreceptor layer (PR) (P < 0.05). G4 had loss in retinal vessel density, thinning in RNFL and GCIPL, and decrease in venular BFV, in addition to thickening of the OPL and PR (P < 0.05). Age was negatively related to retinal vessel densities, the inner retinal layers, and venular BFV (P < 0.05). By contrast, age was positively related to OPL and PR (P < 0.05).ConclusionsDuring aging, decreases in retinal vessel density, inner retinal layer thickness, and venular BFV were evident and impacted each other as observed by simultaneous changes in multiple retinal components.

show abstract

Section: Methodsmentioning

confidence: 99%

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Wei

Jiang

Shi

et al. 2017

Invest. Ophthalmol. Vis. Sci.

Self Cite

130

126

View full text Add to dashboard Cite

show abstract

“…The pupil was dilated with 1% tropiamide and the macular region, centered on the fovea, was imaged (20 degrees with the field of view of 4.3 × 4.3 mm 2 ). 32 More than four well-focused images were obtained from each eye in the 20 degree camera settings for calculating blood flow velocity. Vessels were manually marked using the proprietary software in the RFI.…”

Section: Methodsmentioning

confidence: 99%

Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Jiang

et al. 2017

American Journal of Ophthalmology

Self Cite

178

162

View full text Add to dashboard Cite

Purpose To investigate the changes of the retinal microvascular network and microcirculation in high myopia. Design A cross-sectional, matched, comparative clinical study. Participants Twenty eyes of twenty subjects with non-pathological high myopia (28 ± 5 Years) with a refractive error of −6.31 ± 1.23 Diopters (mean ± standard deviation) and twenty eyes of twenty age- and gender-matched control subjects (30 ± 6 years) with a refractive error of −1.40 ± 1.00 Diopters were recruited. Methods Optical coherence tomography angiography (OCTA) was used to image the retinal microvascular network, which was later quantified by fractal analysis (box counting, Dbox, representing vessel density) in both superficial and deep vascular plexuses. The retinal function imager (RFI) was used to image the retinal microvessel blood flow velocity (BFV). The BFV and microvascular density in the myopia group were corrected for ocular magnification using Bennett’s formula. Results The density of both superficial and deep microvascular plexuses was significantly decreased in the myopia group in comparison to the controls (P < 0.05). The decrease of the microvessel density of the annular zone (0.6 – 2.5 mm), measured as Dbox, was 2.1% and 2.9% in superficial and deep vascular plexuses, respectively. The microvessel density reached a plateau from 0.5 mm to 1.25 mm from the fovea in both groups, but that in myopic group was about 3% lower than the control group. No significant differences were detected between the groups in retinal microvascular BFV in either arterioles or venules (P > 0.05). Microvascular densities in both superficial (r = −0.45, P = 0.047) and deep (r = −0.54, P = 0.01) vascular plexuses were negatively correlated with the axial lengths in the myopic eye. No correlations were observed between BFV and vessel density (P > 0.05). Conclusions Retinal microvascular decrease was observed in the high myopia subjects, whereas the retinal microvessel BFV remained unchanged. The retinal microvascular network alteration may be attributed to ocular elongation that occurs with the progression of myopia. The novel quantitative analyses of the retinal microvasculature may help to characterize the underlying pathophysiology of myopia and enable early detection and prevention of myopic retinopathy.

show abstract

“…Fractal analysis provides a global index that quantifies the geometric complexity of the retinal vascular network, summarizing the entire branching pattern, and may be a more sensitive indicator of early microvascular disease compared with overt retinopathy signs [12]. This method has been applied in patients with Diabetes Mellitus [13], Multiple Sclerosis [14], and high myopia [15].…”

Section: Introductionmentioning

confidence: 99%

Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers

Birkhoff

Manen

Dijkstra

et al. 2019

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Purpose Fractal analysis can be used to quantitatively analyze the retinal microvasculature and might be a suitable method to quantify retinal capillary changes in sickle cell disease (SCD) patients. Retinal oximetry measurements might function as a proxy for the pathophysiology of cerebrovascular diseases. Moreover, hypoxia has an important role in the pathophysiology of diabetic and other retinopathies. However, little is known about the oximetry around the macula in SCD patients. With this study, we explored the feasibility to perform these quantified measurements in SCD patients. Methods Retinal microvascular and oximetry measurements were performed in eight SCD patients and eight healthy matched controls. Oximetry pictures and non-invasive capillary perfusion maps (nCPM) were obtained by the retinal function imager. Measurements were conducted twice on two different study days. Measured variables included monofractal dimension (Dbox), relative saturation, deoxygenated hemoglobin (deoxyHb), and oxygenated hemoglobin (oxyHb) concentration. Results No statistically significant differences in vessel density were found in the different annular zones (large vessels, p = 0.66; small vessels, p = 0.66) and anatomical quadrants (large vessels, p = 0.74; small vessels, p = 0.72). Furthermore, no significant between-group differences were found in the other different anatomical quadrants and annular zones around the fovea for relative saturation levels and deoxygenated Hb. However, the oxyHb levels were significantly lower in SCD patients, compared with those in matched controls in the temporal quadrants (p = 0.04; p = 0.02) and the superior nasal quadrant (p = 0.05). Conclusions Our study demonstrated the feasibility of multispectral imaging to measure retinal changes in oxygenation in both SCD patients and matched volunteers. The results suggest that in SCD patients before any structural microvascular changes in the central retina are present, functional abnormalities can be observed with abnormal oximetry measurements. Keywords Sickle cell disease. Retina analysis. Microvessels. Image processing. Computer-assisted W. A. J. Birkhoff and L. van Manen contributed equally to this work.

show abstract

Impaired retinal microcirculation in multiple sclerosis

Cited by 51 publications

References 32 publications

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Age-Related Alterations in the Retinal Microvasculature, Microcirculation, and Microstructure

Retinal Microvascular Network and Microcirculation Assessments in High Myopia

Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers

Contact Info

Product

Resources

About