Impaired response of cardiac autonomic nervous system to glucose load in severe obesity

Quilliot, Didier; Zannad, Faı̈ez; Ziegler, O.

doi:10.1016/j.metabol.2005.03.002

Cited by 12 publications

(14 citation statements)

References 42 publications

(50 reference statements)

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“…Our findings also contrast a recent report (16) which demonstrated that both the sympathetic and parasympathetic nervous system were stimulated by a glucose challenge in obese subjects. Class III obesity (BMI>40 kg/m 2 ) was associated with a blunted increase in the sympathetic response to the glucose load, even though they had a larger increase in plasma insulin levels.…”

Section: Glucose Challengecontrasting

confidence: 99%

“…Although acute euglycemic hyperinsulinemia alters the HRV response in healthy individuals (3,4), little research on autonomic function has been conducted in the obese population during an acute glucose load and a physiologic challenge (15,16) and no information is available on obese individuals with type 2 diabetes. Quantifying the ANS response to a physiologic challenge can provide important information on autonomic dysfunction not evident at rest (17); such information is important to elucidate the autonomic response to common everyday challenges in these populations.…”

Section: Introductionmentioning

confidence: 99%

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The effects of a glucose load and sympathetic challenge on autonomic function in obese women with and without type 2 diabetes mellitus

et al. 2007

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This study examined the effect of glucose ingestion on cardiac autonomic function in non-obese women and obese women with and without type 2 diabetes. Heart rate variability (HRV) was measured via continuous ECG and beat-by-beat blood pressure was recorded with finger photoplethysmography (Portapress) in a fasted state and in response to a 75 g glucose load in 42 middle-aged women (40-60 yr). Upright tilt was also utilized as an orthostatic stress to provide a clinically relevant challenge to the cardiovascular system. Significant main effects for log transformed (Ln) total power (TP, msec 2 ) were observed with upright tilt (P<0.01) and glucose challenge (P<0.05). LnTP decreased in all groups in both the fasted and fed state with upright tilt (P<0.01), but glucose ingestion resulted in higher LnTP in the supine position only (P=0.008). Tilt resulted in a significant main effect for low frequency (LFnu, normalized units) and high frequency (Hfnu) power (P<0.000), while the glucose challenge had no effect on LFnu or HFnu power. LFnu approached significance for group differences (P=0.07), such that the non-obese had lower LF power than either of the obese groups. Sympathovagal balance (LnLF/HF ratio) was affected by position (P<0.000) and group (P<0.05), with a lower LnLF/HF in the non-obese than in the obese women. Baroreceptor sensitivity decreased (P<0.01) during upright tilt but was not changed by the glucose challenge. In conclusion, basal sympathovagal balance is higher in obese individuals with and without type 2 diabetes. Women with type 2 diabetes showed no differences in autonomic function with an orthostatic challenge or glucose load than non-diabetic, obese women. The glucose load did alter total spectral power in all of these middle-aged women, but had no impact on baroreceptor sensitivity.Jill Kanaley, PhD, 820 Comstock Ave, Rm 201, Syracuse, NY 13244, 315-443-9698 phone, 315-443-9375 fax Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

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Section: Glucose Challengecontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of a glucose load and sympathetic challenge on autonomic function in obese women with and without type 2 diabetes mellitus

et al. 2007

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“…This increase occurs mainly due to the increasing blood flow and cardiac output requirement, to redirect the oxygenated blood to active muscles 22 . Even though glucose intake and increased insulin concentrations induce changes in HR response to exercise 14 , the present investigation showed that postprandial exercise promotes a similar HR response compared to fasted exercise.…”

Section: Discussionmentioning

confidence: 47%

“…On the other hand, glucose intake and the increase in plasma insulin concentration promote a higher activity of the sympathetic nervous system, stimulating alterations in cardiac autonomic function, HR variability and BP 14 . Thus, the significant increase in systolic BP induced by exercise in the postprandial condition can also be explained by the high glycemic load contained in the provided meal, since glucose intake induces a marked increase of insulin production and release 24 .…”

Section: Discussionmentioning

confidence: 99%

“…Accordingly, abnormally large falls in BP after a meal (postprandial hypotension) occurs due to the absence of elevated levels of catecholamine and may indicate a dysfunction of the sympathetic nervous system 13 . In addition, insulin response induced by glucose consumption can cause changes in the stimulation of the autonomic nervous system affecting the regulation of BP 14 .…”

Section: Introductionmentioning

confidence: 99%

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Acute Cardiovascular Response to Pre-Prandial and Postprandial Exercise in Active Men

Mota

Chaves

Dutra

et al. 2017

Rev Bras Med Esporte

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Introduction: Pre-prandial exercise promotes greater mobilization of fat metabolism due to the increased release of catecholamines, cortisol, and glucagon. However, this response affects how the cardiovascular system responds to exercise. Objective: To evaluate the response of systolic, diastolic, and mean blood pressure, heart rate (HR) and rate-pressure product (RPP) to pre-and postprandial exercise. Methods: Ten physically active male subjects (25.50 ± 2.22 years) underwent two treadmill protocols (pre-and postprandial) performed for 36 minutes at 65% of VO 2 max on different days. On both days, subjects attended the laboratory on a 10-hour fasting state.

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Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

Barchetta

Cimini

Ciccarelli

et al. 2019

J Endocrinol Invest

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Impaired response of cardiac autonomic nervous system to glucose load in severe obesity

Cited by 12 publications

References 42 publications

The effects of a glucose load and sympathetic challenge on autonomic function in obese women with and without type 2 diabetes mellitus

The effects of a glucose load and sympathetic challenge on autonomic function in obese women with and without type 2 diabetes mellitus

Acute Cardiovascular Response to Pre-Prandial and Postprandial Exercise in Active Men

Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation

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