Impaired renal function in morbid obese patients with nonalcoholic fatty liver disease

Abstract

In morbid obese patients, NASH, particularly lobular inflammation and advanced fibrosis, associates with mild decreases in eGFR, suggesting a common inflammatory link between liver and renal lesion.

Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age

“…Targher G et al believed that fatty and inflamed liver produces pro-inflammatory factors which can further worsen kidney function [23]. Machado MV et al found that the presence and severity of liver inflammation correlated linearly with lower eGFR in their study [24]. …”

Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease

“…In the last 5 years, a number of cross-sectional community-based and hospital-based studies have consistently demonstrated that NAFLD, as diagnosed either by imaging [16][17][18][19][20][21][22][23][24] or by histology [25][26][27][28][29] , is associated with an increased prevalence of CKD (defined as presence of decreased estimated glomerular filtration rate [eGFR] or abnormal albuminuria or overt proteinuria) in patients with NAFLD. In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] .…”

“…In these studies, the prevalence of CKD in patients with NAFLD ranged from approximately 20% to 55% compared to 5%-30% in those without NAFLD [16][17][18][19][20][21][22][23][24][25][26][27][28][29] . Notably, in most of these studies the association between NAFLD and CKD was independent of common cardio-renal risk factors across a wide range of patient populations.…”

“…Finally, some smaller case-control studies that used liver biopsies to diagnose NAFLD have also shown that there is a significant, graded relationship between the histological severity of NAFLD (principally the hepatic fibrosis stage) and the presence of either decreased kidney function or abnormal albuminuria [25][26][27][28][29] . However, it is important to underline that none of these studies have used renal biopsy to examine the pathology of their CKD (so, it is currently unknown if NAFLD is associated with a specific type of kidney disease).…”

Association Between Urinary Alpha1-Microglobulin Levels and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

“…In addition, a retrospective chart review of 38,533 patients from the United Network for Organ Sharing database of the United States revealed that NASH was the most rapidly increasing indication for simultaneous liver-kidney transplantation with poor renal outcomes [15]. Taken together, these studies indicate that either NAFLD is a risk factor for the development of CKD, or that NAFLD and CKD may share common pathogenic factors and mutually interact [16, 17]. …”