Impaired Pulmonary Function in Patients with Psoriasis

Abstract

Background: Psoriasis is associated with chronic obstructive pulmonary disease. There is no study on the spirometric pulmonary function testing in patients with psoriasis. Objective: The aim of this study was to compare the spirometric parameters in patients with psoriasis and controls. Methods: Ninety-six patients with psoriasis and 60 sex- and age-matched control subjects were included in this study. Spirometric pulmonary function testing, including percent forced vital capacity (FVC%), percent forced expiratory volume in the 1st second (FEV₁%), forced expiratory flow at 25-75% of FVC (FEF_25-75%), and FEV₁/FVC ratio, was performed in all study subjects. Results: The mean FEV₁/FVC ratio and FEF_25-75% were significantly lower in the psoriasis patients than in the controls (82.4 ± 6.3 vs. 90.7 ± 10.7, p < 0.001, and 86.7 ± 24.2 vs. 94.8 ± 23.0, p = 0.04, respectively). Both FEV₁/FVC ratio and FEF_25-75% were significantly associated with the presence of psoriasis (p < 0.001 and p = 0.029, respectively). Conclusion: Psoriasis patients had lower mean FEV₁/FVC ratios and FEF_25-75%, compared with the control subjects. FEV₁/FVC and FEF_25-75% are independently associated with the presence of psoriasis.

Pulmonary function in patients with psoriasis: across-sectional population study

“…Moreover, patients with psoriasis display increased risk of infections, especially respiratory infections including pneumonia . However, only a small single‐centre study of pulmonary function in participants with psoriasis is available …”

“…Although epidemiological studies have found increased risk of COPD and asthma only a single report is available on pulmonary function in psoriasis . These investigators found a reduced FEV 1 /FVC ratio but unaltered FEV 1 in participants with psoriasis ( n = 69) attending a dermatology clinic compared with controls with various other skin diseases .…”

“…4 Although epidemiological studies have found increased risk of COPD and asthma 2-4 only a single report is available on pulmonary function in psoriasis. 6 These investigators found a reduced FEV 1 /FVC ratio but unaltered FEV 1 in participants with psoriasis (n = 69) attending a dermatology clinic compared with controls with various other skin diseases. 7 In that report, participants with psoriasis were also younger (mean age 42Á8 years) than in our study and did not display certain psoriatic phenotype characteristics, for example increased BMI found in our study.…”

“…1,5 However, only a small single-centre study of pulmonary function in participants with psoriasis is available. 6 We performed a cross-sectional study of spirometric values in individuals with self-reported psoriasis compared with controls that participated in the Danish General Suburban Population Study. 7 A total of 20 422 individuals over 20 years old including 1173 (5Á7%) with psoriasis and 19 249 in the comparison group underwent pulmonary function test with use of a hand-held spirometer (MicroLoop, Micro Medical Ltd, Kent, U.K.).…”

Are psoriasis and psoriatic arthritis associated with chronic obstructive pulmonary disease?

“…However, the connection fails to have been well-analysed. Both diseases are provoked by similar factors such as smoking, abdominal obesity, lack of physical activity, and concomitance of the metabolic syndrome [1][2][3].…”