2009
DOI: 10.1016/j.biopsych.2008.11.026
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Impaired Prefrontal Cortical Function and Disrupted Adaptive Cognitive Control in Methamphetamine Abusers: A Functional Magnetic Resonance Imaging Study

Abstract: Background-Methamphetamine (MA) abuse is associated with neurotoxicity to frontostriatal brain regions with concomitant deleterious effects on cognitive processes. Deficits in behavioral control are thought to be one contributing factor to the sustainment of addictive behaviors in chronic MA abuse.

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Cited by 128 publications
(145 citation statements)
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References 20 publications
(23 reference statements)
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“…Our observation of greater activation of the ACC under modafinil than placebo conditions in the MA group has particular therapeutic relevance, as the ACC has been shown to be hypoactive in MA subjects (as compared with activity in control subjects) during tests of cognitive control (Salo et al, 2009) and vigilance . The boost in ACC activation observed with modafinil likely reflects greater engagement of cognitive processes important for learning, especially as ACC activation has been previously shown to correlate positively with learning performance on this task in control subjects (Ghahremani et al, 2010).…”
Section: Discussionmentioning
confidence: 69%
See 1 more Smart Citation
“…Our observation of greater activation of the ACC under modafinil than placebo conditions in the MA group has particular therapeutic relevance, as the ACC has been shown to be hypoactive in MA subjects (as compared with activity in control subjects) during tests of cognitive control (Salo et al, 2009) and vigilance . The boost in ACC activation observed with modafinil likely reflects greater engagement of cognitive processes important for learning, especially as ACC activation has been previously shown to correlate positively with learning performance on this task in control subjects (Ghahremani et al, 2010).…”
Section: Discussionmentioning
confidence: 69%
“…Moreover, MA-dependent subjects exhibit abnormal structure and function of the anterior cingulate cortex (ACC) Salo et al, 2009;Thompson et al, 2004), a cortical structure that is associated with reward processing and has a major projection to dopamine-rich ventral striatal areas (Haber and Knutson, 2010). In light of evidence that modafinil raises ACC activation from a hypoactive state in patient groups (eg, schizophrenia) commensurate with improving behavioral performance in some participants (Spence et al, 2005), ACC appears to be a likely cortical target for the potential cognition-enhancing benefits of modafinil in MA-dependent subjects.…”
Section: Introductionmentioning
confidence: 99%
“…These meth-induced cortical disruptions may reduce the ability to regulate subcortical drives in limbic structures, including the NAc (Goldstein et al, 2009). Consistent with this hypothesis, human meth addicts often exhibit enduring PFC-dependent cognitive deficits in tasks requiring attention, working memory, and suppression of irrelevant information (Baicy and London, 2007;Salo et al, 2009), as well as enduring downregulation of DA transporter (DAT) function in the frontal cortex, NAc, and caudate/putamen (Chang et al, 2007;McCann et al, 2008). Reductions in basal NAc GLU following cocaine selfadministration have been attributed to decreased affinity of the cystine-GLU exchanger (Baker et al, 2003;McFarland et al, 2003).…”
Section: Discussionmentioning
confidence: 86%
“…Methamphetamine (meth) addicts often exhibit pronounced deficits in cortical regulation of subcortical drive (Baicy and London, 2007;Salo et al, 2009). The impact of meth on this circuitry may be more profound than other addictive drugs, due in part to its long half-life, high-lipid solubility, fast uptake and accumulation, and distinctive pharmacological effects on both DA and GLU functions (Bowyer et al, 2008;Fowler et al, 2008;Stephans and Yamamoto, 1994).…”
Section: Introductionmentioning
confidence: 99%
“…27 Furthermore, individuals with schizophrenia and stimulant drug addiction exhibit exaggerated striatal DA release in response to an amphetamine challenge, but appear to have blunted DA activity in the mPFC. [28][29][30][31][32][33][34][35][36] (For possible mechanisms accounting for the inhibitory control of DA activity in mPFC over DA activity in the nucleus accumbens, see Carr and Sesack, 10 Sesack and Pickel 37 and Gao and colleagues.…”
Section: Reciprocal Relations Between Mesolimbic and Mesocortical Da mentioning
confidence: 99%