Impaired pre-attentive change detection in major depressive disorder patients revealed by auditory mismatch negativity

Qiao, Zhengxue; Yu, Yunmiao; Wang, Lin; Yang, Xiuxian; Qiu, Xiaohui; Zhang, Congpei; Ning, Ning; Shi, Jing; Chen, Lu; Li, Zhiyong; Liu, Jianping; Xu, Jia Bin; Zhao, Lun; Yang, Yanjie

doi:10.1016/j.pscychresns.2012.07.006

Cited by 36 publications

(36 citation statements)

References 49 publications

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“…Now, converging evidence suggests that auditory information processing may be impaired in depression. This is in line with results of an EEG study by Qiao et al (2013). Indeed, the ROI analysis revealed reduced activation in the right auditory cortex presumably reflecting impaired sensory processing on the level of the auditory cortex in patients.…”

Section: Discussionsupporting

confidence: 90%

“…EEG and MEG studies in patients with depression yielded inconsistent findings. Deficits in mismatch processing were confirmed in subsequent investigations (Chen et al, 2015;Qiao et al, 2013). Deficits in mismatch processing were confirmed in subsequent investigations (Chen et al, 2015;Qiao et al, 2013).…”

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confidence: 54%

“…For example, patients show reduced auditory pitch identification (Schwenzer et al, 2012) and disturbed information processing in the auditory domain (Qiao et al, 2013;Takei et al, 2009;Tollkötter, Pfleiderer, Sörös, & Michael, 2006). Now, converging evidence suggests that auditory information processing may be impaired in depression.…”

Section: Discussionmentioning

confidence: 99%

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Fronto‐parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing

Zweerings

Zvyagintsev

Turetsky

et al. 2019

Human Brain Mapping

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Mismatch responses reflect neural mechanisms of early cognitive processing in the auditory domain. Disturbances of these mechanisms on multiple levels of neural processing may contribute to clinical symptoms in major depression (MD). A functional magnetic resonance imaging (fMRI) study was conducted to identify neurobiological foundations of altered mismatch processing in MD. Twenty‐five patients with major depression and 25 matched healthy individuals completed an auditory mismatch paradigm optimized for fMRI. Brain activity during mismatch processing was compared between groups. Moreover, seed‐based connectivity analyses investigated depression‐specific brain networks. In patients, mismatch processing was associated with reduced activation in the right auditory cortex as well as in a fronto‐parietal attention network. Moreover, functional coupling between the right auditory cortex and frontal areas was reduced in patients. Seed‐to voxel analysis on the whole‐brain level revealed reduced connectivity between the auditory cortex and the thalamus as well as posterior cingulate. The present study indicates deficits in sensory processing on the level of the auditory cortex in depression. Hyposensitivity in a fronto‐parietal network presumably reflects altered attention mechanisms in depression. The observed impairments may contribute to psychopathology by reducing the ability of the affected individuals to orient attention toward important environmental cues.

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Section: Discussionsupporting

confidence: 90%

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confidence: 54%

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Fronto‐parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing

Zweerings

Zvyagintsev

Turetsky

et al. 2019

Human Brain Mapping

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“…He et al [31] also reported enhanced frequency-MMN amplitudes in treatment-resistant depressed individuals compared with healthy volunteers. In contrast, a recent study conducted by Qiao et al [32] found that patients with MDD exhibited decreased duration-MMN amplitudes over the frontal–central area under the increment condition (150 ms MMN), although no significant difference between patients and healthy controls was found for temporal MMN regardless of whether the increment or decrement (50 ms MMN) condition was used. They also reported that the MMN of patients with MDD had longer peak latency than did that of healthy controls.…”

Section: Introductionmentioning

confidence: 68%

Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder

Pang

Chang

et al. 2014

PLoS ONE

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BackgroundMajor depressive disorder (MDD) is an important and highly prevalent mental disorder characterized by anhedonia and a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits in various cognitive abilities. Although a number of studies investigating the central auditory processing of low-level sound features in patients with MDD have demonstrated that this population exhibits impairments in automatic processing, the influence of emotional voice processing has yet to be addressed. To explore the automatic processing of emotional prosodies in patients with MDD, we analyzed the ability to detect automatic changes using event-related potentials (ERPs).MethodThis study included 18 patients with MDD and 22 age- and sex-matched healthy controls. Subjects were instructed to watch a silent movie but to ignore the afferent acoustic emotional prosodies presented to both ears while continuous electroencephalographic activity was synchronously recorded. Prosodies included meaningless syllables, such as “dada” spoken with happy, angry, sad, or neutral tones. The mean amplitudes of the ERPs elicited by emotional stimuli and the peak latency of the emotional differential waveforms were analyzed.ResultsThe sad MMN was absent in patients with MDD, whereas the happy and angry MMN components were similar across groups. The abnormal sad emotional MMN component was not significantly correlated with the HRSD-17 and HAMA scores, respectively.ConclusionThe data indicate that patients with MDD are impaired in their ability to automatically process sad prosody, whereas their ability to process happy and angry prosodies remains normal. The dysfunctional sad emotion-related MMN in patients with MDD were not correlated with depression symptoms. The blunted MMN of sad prosodies could be considered a trait of MDD.

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“…Reduced MMN is less prevalent in related conditions, such as bipolar affective disorder independent of the presence of psychotic symptoms (52, 66–68) and in major depression (66) but see (69–71). That is, there is considerable evidence that criterion (i) is met in terms of its association with the illness, although its specificity to schizophrenia is less clear than initially thought.…”

Section: Does Mmn-reduction Indicate Vulnerability To Schizophrenia?mentioning

confidence: 99%

Mismatch Negativity: Translating the Potential

et al. 2013

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The mismatch negativity (MMN) component of the auditory event-related potential has become a valuable tool in cognitive neuroscience. Its reduced size in persons with schizophrenia is of unknown origin but theories proposed include links to problems in experience-dependent plasticity reliant on N-methyl-d-aspartate glutamate receptors. In this review we address the utility of this tool in revealing the nature and time course of problems in perceptual inference in this illness together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes. Specifically, we review the reasons for interest in MMN in schizophrenia, issues pertaining to the measurement of MMN, its use as a vulnerability index for the development of schizophrenia, the pharmacological sensitivity of MMN and the progress in developing animal models of MMN. Within this process we highlight the challenges posed by knowledge gaps pertaining to the tool and the pharmacology of the underlying system.

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Impaired pre-attentive change detection in major depressive disorder patients revealed by auditory mismatch negativity

Cited by 36 publications

References 49 publications

Fronto‐parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing

Fronto‐parietal and temporal brain dysfunction in depression: A fMRI investigation of auditory mismatch processing

Mismatch Negativity of Sad Syllables Is Absent in Patients with Major Depressive Disorder

Mismatch Negativity: Translating the Potential

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