Impaired Phorbol Ester-Induced Hepatocyte Proliferation in Cirrhosis

Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma

“…Another form of healing process in the liver is fibrosis in response to liver damage. In the decompensated stage of cirrhosis with its depressed hepatic regeneration, 28 cytokines appear to play modulating roles, as shown, for example, for TGF‐α, TGF‐ β, HGF and EGF 29 . TGF‐α, HGF and EGF act as hepatotrophic factors 5,30 and elevated levels of mRNA 31–34 as well as protein expression of these growth factors 33,34 are found in cirrhotic tissues.…”