Impaired Phenotype of Circulating Endothelial-Derived Microparticles: Novel Marker of Cardiovascular Risk

Berezin, Alexander E.

doi:10.17554/j.issn.2309-6861.2015.02.78

Cited by 28 publications

(27 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority investigations have now addressed to the endothelial cell-derived MPs, which are marker of endothelial dysfunction and cardiovascular death [47,48], while MPs originated from other cells (i.e. red blood cells) have exhibited a relation to severity of atherosclerosis and coronary obstruction [49].…”

Section: Biological Role and Function Of Mpsmentioning

confidence: 99%

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

Berezin¹

2017

JCTCD

View full text Add to dashboard Cite

Section: Biological Role and Function Of Mpsmentioning

confidence: 99%

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

Berezin¹

2017

JCTCD

View full text Add to dashboard Cite

“…Indeed, SUA levels independently and inversely associated with number of circulating endothelial progenitor cells in HF individuals [21]. Moreover, uric acid contributed in shaping of altered ability of endothelial precursors to activate by several stimuli, release cell secretome, regulate endothelial reparation and turn into mature endothelial cells [22,23]. Consequently, uric acid may consider as an endogenous regulator of vascular repair system that undoubtedly opens new sign on the role of uric acid metabolism as integrative asset explaining an impact of various comorbidities on a risk of HF manifestation.…”

Section: Short Communicationmentioning

confidence: 99%

Serum uric acid as a metabolic regulator of endothelial function in heart failure

Berezin¹

2017

Arch Clin Hypertens

View full text Add to dashboard Cite

Citation: Berezin AE (2017) Serum uric acid as a metabolic regulator of endothelial function in heart failure. Arch Clin Hypertens 3(1): 027-029. DOI: http://dx.doi.org/10.17352/ach.000016 AbstractThe development of heart failure (HF) associated with elevated level of serum uric acid (SUA). Additionally, the majority of individuals with traditional cardiovascular risk factors contributing in HF risk exhibited increased levels of SUA. Although SUA lowering drugs are widely used in patients with symptomatic hyperuricemia and gout beyond their etiologies, there is no agreement of SUA below target level 6.0 mg/dL in asymptomatic individuals with kidney injury and CV disease and data of ones in heart failure (HF) are suffi ciently controversial. First SUA plays an important role in inducing oxidative stress, infl ammation, neurohumoral activation, and endothelial dysfunction. Secondary, SUA may act as antioxidant contributing in restoring of vascular function. Moreover, SUA is able to epigenetically regulate a survival of endothelial precursors, mediate their mobbing and differentiation, as well as coordinate a turn-over effect of metabolic memory phenomenon into repair capability of cell precursors. However, elevated SUA level was found a predictor of adverse clinical outcomes of HF. The short communication is depicted the importance of new clinical data to confi rm the emerging reparative ability of SUA in HF and its role as promising target for treatment in cardiac failure. Short Communication Serum uric acid as a metabolic regulator of endothelial function in heart failureAlexander E Berezin* Short CommunicationThere is a large body of evidence regarding the role of serum uric acid (SUA) in pathogenesis of cardiovascular diseases (CVD) including heart failure (HF). Although SUA levels above the current international reference limit equal 6.0 mg/dL are highly prevalent in chronic kidney disease (CKD), hyperuricemia strongly associates with in-hospital CV mortality independently from CKD etiology and renal function in individuals admitted to the hospital due to several causes, i.e. acute myocardial infarction, stroke, hypertensive emergencies, acute / chronic heart failure, arrhythmia, shock and sepsis.In contrast, hypouricemia did not associate with increased mortality rate in patient populations with established CVD [1]. In HF an elevated SUA level was found due to several mechanisms including an increased activity of xanthine oxidase (XO), which is a key enzyme in uric acid synthesis and is under control of infl ammatory cytokines / chemokines, some growth factors, and intermediates (blood glucose). Whether SUA could be an independent predictor of HF development is not fully clear. Recent clinical studies and some meta-analysis have shown that elevated SUA levels were associated with an increased risk of incident HF, observed in majority of patients with established chronic HF and relate to adverse clinical outcomes in HF [8][9][10][11]. However, the impact of uric acid on all-cause mortality and HF-related dea...

show abstract

“…Altered miRNA signature risk of CV death [32][33][34][35][36][37] . Whether interactions between features of transcriptomics, proteomics and metabolomics are specifically for HFrEF and HFpEF remains still not clear.…”

Section: Histone Acetylationmentioning

confidence: 99%

Are Epigenetic Features Essential in Advance of Heart Failure Phenotypes?

Berezin

2016

Journal of Cardiology and Therapy

View full text Add to dashboard Cite

Impaired Phenotype of Circulating Endothelial-Derived Microparticles: Novel Marker of Cardiovascular Risk

Cited by 28 publications

References 63 publications

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

The number of red blood cell-derived microparticles in predicting periprocedural adverse effects in acute STsegment elevation myocardial infarction patients

Serum uric acid as a metabolic regulator of endothelial function in heart failure

Are Epigenetic Features Essential in Advance of Heart Failure Phenotypes?

Contact Info

Product

Resources

About