Impaired Phagocytosis By Macrophages In Sle

Svensson, Björn; Hedberg, H.

doi:10.3109/03009747309098821

Cited by 13 publications

(3 citation statements)

References 3 publications

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“…While it is understandable that immunosuppression can predispose to infection, it does not account for the cases of cooccurrence of salmonellosis with the ®rst presentation of SLE, 7,15 unless one considers active SLE itself as an immunocompromised state. 15,16 Mechanisms advanced to explain this inherent or iatrogenic insuf-®ciency of the SLE patient's reticuloendothelial system in clearing Salmonella include inadequate opsonization, 17 impaired mononuclear phagocytosis, 18,19 functional hyposplenism, 20,21 and hypocomplementaemia. 1,2 The particular occurrence of Salmonella could be partly attributed to it being a common faeco-oral pathogen prevalent in Asian societies where sharing of eating utensils is customary; or where less hygienic food preparation habits are practised.…”

Section: Discussionmentioning

confidence: 99%

Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature

Lim

Wh²,

Sf³

et al. 2001

Lupus

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The objective of this study was to characterize the clinical profile of lupus patients with non-typhoidal salmonellosis. A retrospective review of the clinical charts of lupus patients diagnosed with bacteriologically proven non-typhoidal salmonellosis over the last 20 y was undertaken, paying special attention to risk factors, clinical presentation and treatment outcome. Most episodes were bacteraemic without a localizing focus; and some patients were afebrile. They usually occurred in patients prone to opportunistic infections, and at times of increased immunosuppression given for lupus flares (especially nephritis). However, salmonellosis also occurred in some patients presenting with lupus. The C-reactive protein level was found to be significantly higher during the infective episodes compared to episodes of non-infective febrile lupus flare. All isolates were sensitive to the usual first-line antibiotics and eminently treatable with 3 weeks of appropriate antibiotics without recurrence/persistence or significant morbidity/mortality, the exceptions being spinal osteomyelitis and septic arthritis involving deformed joints requiring surgical debridement and prolonged antibiotic therapy for eradication. Mortality occurred in the setting of septic shock from mixed-microbial sepsis and major organ failure from active lupus. There is a high association of non-epidemic, non-typhoidal salmonellosis with SLE, especially in patients with active disease on intensified immunosuppression. The C-reactive protein value may be helpful in distinguishing between fever from a pure lupus flare and one complicated by infection.

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Section: Discussionmentioning

confidence: 99%

Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature

Lim

Wh²,

Sf³

et al. 2001

Lupus

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“…In addition to early observations that SLE patients display impaired phagocytic capabilities (19)(20)(21), we recently reported that the uptake of apoptotic cell material by macrophages derived from monocytes of patients with SLE is also markedly impaired in vitro (22). To investigate whether this defect in engulfment of apoptotic cell material can also be observed in vivo, we histologically analyzed lymph node biopsy specimens that had been removed for diagnostic purposes from SLE patients with benign follicular hyperplasia, and from non-SLE patients with benign follicular hyperplasia (non-SLE), patients with malignant follicular lymphoma (FL) and patients with dermatopathic lymphadenitis, all of whom served as controls.…”

mentioning

confidence: 99%

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus

Baumann¹,

Kolowos²,

Voll³

et al. 2002

Arthritis & Rheumatism

504

280

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“…In addition to early observations that SLE patients display impaired phagocytic capabilities (19–21), we recently reported that the uptake of apoptotic cell material by macrophages derived from monocytes of patients with SLE is also markedly impaired in vitro (22). To investigate whether this defect in engulfment of apoptotic cell material can also be observed in vivo, we histologically analyzed lymph node biopsy specimens that had been removed for diagnostic purposes from SLE patients with benign follicular hyperplasia, and from non–SLE patients with benign follicular hyperplasia (non‐SLE), patients with malignant follicular lymphoma (FL) and patients with dermatopathic lymphadenitis, all of whom served as controls.…”

mentioning

confidence: 96%

Some notes on poisson limits for empirical point processes

2009

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The authors define the scaled empirical point process. They obtain the weak limit of these point processes through a novel use of a dimension‐free method based on the convergence of compensators of multiparameter martingales. The method extends previous results in several directions. They obtain limits at points where the density may be zero, but has regular variation. The joint limit of the empirical process evaluated at distinct points is given by independent Poisson processes. They provide applications both to nearest‐neighbour density estimation in high dimensions, and to the asymptotic behaviour of multivariate extremes such as those arising from bivariate normal copulas. The Canadian Journal of Statistics 37: 347–360; 2009 © 2009 Statistical Society of Canada

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Impaired Phagocytosis By Macrophages In Sle

Cited by 13 publications

References 3 publications

Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature

Non-thyphoidal salmonellosis in patients with systemic lupus erythematosus. A study of fifty patients and a review of the literature

Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus

Some notes on poisson limits for empirical point processes

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