Impaired Parahippocampus Connectivity in Mild Cognitive Impairment and Alzheimer’s Disease

Liu, Jieqiong; Zhang, Xinqing; Yu, Chunshui; Duan, Yunyun; Zhuo, Junjie; Cui, Yue; Liu, Bing; Li, Kuncheng; Jiang, Tianzi; Liu, Yong

doi:10.3233/jad-150727

Cited by 52 publications

(34 citation statements)

References 88 publications

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“…There is increasing recognition that thinning of the parahippocampal gyrsus my account for impaired pattern recognition on early AD (Bar & Aminoff, 2003; J. Liu et al, 2015).…”

Section: Additional Novel Cognitive Paradigmsmentioning

confidence: 99%

Novel Cognitive Paradigms for the Detection of Memory Impairment in Preclinical Alzheimer’s Disease

et al. 2017

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In spite of advances in neuroimaging and other brain biomarkers to assess preclinical Alzheimer’s disease (AD), cognitive assessment has relied on traditional memory paradigms developed well over six decades ago. This has led to a growing concern about their effectiveness in the early diagnosis of AD which is essential to develop preventive and early targeted interventions before the occurrence of multisystem brain degeneration. We describe the development of novel tests that are more cognitively challenging, minimize variability in learning strategies, enhance initial acquisition and retrieval using cues, and exploit vulnerabilities in persons with incipient AD such as the susceptibility to proactive semantic interference, and failure to recover from proactive semantic interference. The advantages of various novel memory assessment paradigms are examined as well as how they compare with traditional neuropsychological assessments of memory. Finally, future directions for the development of more effective assessment paradigms are suggested.

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“…There is increasing recognition that thinning of the parahippocampal gyrsus my account for impaired pattern recognition on early AD (Bar & Aminoff, 2003; J. Liu et al, 2015).…”

Section: Additional Novel Cognitive Paradigmsmentioning

confidence: 99%

Novel Cognitive Paradigms for the Detection of Memory Impairment in Preclinical Alzheimer’s Disease

et al. 2017

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“…Further, the reduced hippocampal volume is a relatively consistent finding in individuals with PTSD (Karl et al, ; Kitayama, Vaccarino, Kutner, Weiss, & Bremner, ; Woon, Sood, & Hedges, ). Whether this reduced hippocampal volume is causal or the result of exposure to stress and trauma remains a matter of continued investigation but has importance in examinations of the correlation between PTSD and cognitive decline as stress‐related changes in hippocampal structure/volume and function are noted even in healthy individuals with demonstrated reductions in cognitive performance (Gianaros et al, ; J. Liu et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Whether this reduced hippocampal volume is causal or the result of exposure to stress and trauma remains a matter of continued AVERILL ET AL. | 835 investigation but has importance in examinations of the correlation between PTSD and cognitive decline as stress-related changes in hippocampal structure/volume and function are noted even in healthy individuals with demonstrated reductions in cognitive performance (Gianaros et al, 2007;J. Liu et al, 2016).…”

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confidence: 99%

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

et al. 2019

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Background Although the ε4 allele of the apolipoprotein E (APOE) gene and posttraumatic stress disorder (PTSD) have been linked to cognitive dysfunction and dementia risk, it is unknown whether they interact to predict cognitive dysfunction. Methods We analyzed data from European‐American (EA) veterans who participated in the National Health and Resilience in Veterans Study (NHRVS): main sample (n = 1,386) and primary replication sample (n = 509). EAs from the Yale–Penn Study cohort (n = 948) served as a second replication sample. Multivariable analyses were conducted to evaluate the predictive effects of ε4 carrier status and PTSD on cognitive functioning, with a focus on whether PTSD moderates the effect of ε4 carrier status. Results APOE ε4 allele carrier status (d = 0.15 and 0.17 in the main and primary replication NHRVS samples, respectively) and PTSD (d = 0.31 and 0.17, respectively) were independently associated with lower cognitive functioning. ε4 carriers with PTSD scored lower than those without PTSD (d = 0.68 and 1.29, respectively) with the most pronounced differences in executive function (d's = 0.75–1.50) and attention/concentration (d's = 0.62–1.33). A significant interaction was also observed in the Yale–Penn sample, with ε4 carriers with PTSD making more perseverative errors on a measure of executive function than those without PTSD (24.7% vs. 17.6%; d = 0.59). Conclusions APOE ε4 allele carriers with PTSD have substantially greater cognitive difficulties than ε4 carriers without PTSD. These results underscore the importance of assessing, monitoring, and treating PTSD in trauma‐affected individuals who are at genetic risk for cognitive decline and dementia.

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“…AD has been described as a disconnection syndrome, that is, connections of functionally or structurally linked brain regions that are part of a network become increasingly disrupted [14][15][16] . This degenerative mechanism has been associated with the cognitive deficits of patients with AD [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

“…Changes of FC (i.e., decreases and increases of connectivity strengths) in AD often involve the hippocampus and the default mode network [30][31][32][33] . With the progression of the disease, structural and functional connectivity distortions affect several networks, particularly those involving the parahippocampus [17,34] . In SD, FC appears to be deteriorated in regions either affected by or proximate to the core of atrophy, located in regions such as the temporal pole, anterior middle temporal gyrus, inferior temporal gyrus, and insula [6,[35][36][37] .…”

Section: Introductionmentioning

confidence: 99%

Functional connectivity alterations of the temporal lobe and hippocampus in semantic dementia and Alzheimer’s disease

Schwab

Afyouni

Chen

et al. 2018

Preprint

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Abbreviations: AD = Alzheimer's disease; FC = functional connectivity; HC = healthy controls; ROI = region of interest; SD = semantic dementia AbstractThe severe semantic memory impairments in semantic dementia have been attributed to a pronounced atrophy and functional disruption of the anterior temporal lobes. In contrast, medial and posterior temporal lobe damage is predominantly found in patients with Alzheimer's disease, and has been associated with episodic memory disturbance. Despite these distinct neuropathological signatures, the hippocampal deterioration common in Alzheimer's disease and semantic dementia appears paradoxical. To gain more insight into the mutual and divergent functional alterations seen in Alzheimer's disease and semantic dementia, we assessed the differences in intrinsic functional connectivity between temporal lobe regions in patients with Alzheimer's disease (n = 16), semantic dementia (n = 23), and healthy controls (n = 17). We used a functional parcellation of the temporal cortex to extract time series. The Alzheimer's disease group showed only a single connection with reduced functional connectivity as compared to the controls. This connection was located between the right orbitofrontal cortex and the right anterior temporal lobe. In contrast, functional connectivity was decreased in the semantic dementia group in six connections, mainly involving the hippocampus, lingual gyrus, temporal pole, and orbitofrontal cortex. We identified a common pathway with semantic dementia, since the functional connectivity between the right anterior temporal lobe and the right orbitofrontal cortex was reduced in both types of dementia. This might be related to semantic impairments observed in both dementia types, and abnormal social behavior at more progressed disease stages. However, to substantiate such claims, longitudinal studies that more strongly relate behavioral outcomes to functional connectivity are needed.

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Impaired Parahippocampus Connectivity in Mild Cognitive Impairment and Alzheimer’s Disease

Cited by 52 publications

References 88 publications

Novel Cognitive Paradigms for the Detection of Memory Impairment in Preclinical Alzheimer’s Disease

Novel Cognitive Paradigms for the Detection of Memory Impairment in Preclinical Alzheimer’s Disease

Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study

Functional connectivity alterations of the temporal lobe and hippocampus in semantic dementia and Alzheimer’s disease

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