Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

Altun, Armağan; Yaprak, Mevlüt; Aktöz, Meryem; Vardar, Selma Arzu; Betul, Ugur Altun; Özbay, Gültaç

doi:10.1016/s0304-3940(02)00368-3

Cited by 56 publications

(37 citation statements)

References 8 publications

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“…A similar situation is apparent in patients with major depression, i.e., disturbed circadian rhythms and a decreased activity of the vasopressinergic SCN neurons (167). Patients with diabetes or coronary heart disease have a flattened melatonin rhythm (168–170). Recently, mutations in the melatonin receptor were linked to an increased risk of type 2 diabetes (150–152), and some large scale genetic studies in humans provided the first evidence for the involvement of disrupted clock gene rhythms in the pathogenesis of obesity and type 2 diabetes.…”

Section: A Disorganized Clockmentioning

confidence: 99%

Circadian disruption and SCN control of energy metabolism

et al. 2011

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In this review we first present the anatomical pathways used by the SCN to enforce its rhythmicity onto the body, especially its energy homeostatic system. The experimental data show that by activating the orexin system at the start of the active phase, the biological clock not only ensures that we wake up on time, but also that our glucose metabolism and cardiovascular system are prepared for increased activity. The drawback of such a highly integrated system, however, becomes visible when our daily lives are not fully synchronized with the environment. Thus, in addition to increased physical activity and decreased intake of high-energy food, also a well-lighted and fully resonating biological clock may help to withstand the increasing “diabetogenic” pressure of today’s 24/7 society.

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Section: A Disorganized Clockmentioning

confidence: 99%

Circadian disruption and SCN control of energy metabolism

et al. 2011

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“…The role of melatonin as a multifunctional molecule and its potential cardiovascular effects are also summarized. Because the pineal gland is active only in darkness, the levels of melatonin in the pineal gland and in blood are high at night and low during the day (Altun et al 2002). In this regard, the obesity-associated oxidative stress and eventual antioxidant interventions in obesity and insulin-resistant states will not be discussed because they have been largely reviewed elsewhere (Houstis et al 2006, Vincent et al 2007, Grattagliano et al 2008, Hopps et al 2010, Otani 2011, Rains & Jain 2011 Melatonin: a multifunctional molecule more than an antioxidant Melatonin or N-acetyl-5-methoxytryptamine is the hormone secreted mainly by the pineal gland that is under the control of the central nervous system via the suprachiasmatic nucleus (SCN) of the hypothalamus.…”

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confidence: 99%

Melatonin and the metabolic syndrome: a tool for effective therapy in obesity‐associated abnormalities?

2012

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The metabolic syndrome (MetS) is a cluster of metabolic abnormalities associated with increased risk for cardiovascular diseases. Apart from its powerful antioxidant properties, the pineal gland hormone melatonin has recently attracted the interest of various investigators as a multifunctional molecule. Melatonin has been shown to have beneficial effects in cardiovascular disorders including ischaemic heart disease and hypertension. However, its role in cardiovascular risk factors including obesity and other related metabolic abnormalities is not yet established, particularly in humans. New emerging data show that melatonin may play an important role in body weight regulation and energy metabolism. This review will address the role of melatonin in the MetS focusing on its effects in obesity, insulin resistance and leptin resistance. The overall findings suggest that melatonin should be exploited as a therapeutic tool to prevent or reverse the harmful effects of obesity and its related metabolic disorders.

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“…Also, patients with ST-segment MI who developed adverse events during follow-up had significantly lower nocturnal melatonin levels than patients without the events (Dominguez-Rodriguez et al, 2006). In another study it was revealed that nocturnal melatonin levels were reduced in patients with cardiac syndrome X vs. controls (Altun et al, 2002). Second, the renin-angiotensinaldosterone system (RAAS) also exhibits circadian rhythm.…”

Section: Sleep-time Hormonesmentioning

confidence: 99%