Impaired neutrophil function in patients with pulmonary tuberculosis and its normalization in those undergoing specific treatment, except the HIV-coinfected cases

Fiorenza, Gladys; Rateni, Liliana; Farroni, Miguel A.; Dlugovitzky, Diana

doi:10.1016/s0928-8244(03)00004-x

Cited by 11 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we demonstrated that components of the innate immune system during COVID‐19 are well preserved. It has previously been shown to have reduced OB activity in patients with severe infections such as HIV and tuberculosis (Dobmeyer et al, 1995 ; Fiorenza et al, 2003 ; Zimmerman & Ringer, 1992 ). However, we found no defect in the ROS production and apoptosis in monocytes and neutrophils.…”

Section: Discussionmentioning

confidence: 99%

Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

Ekşioğlu-Demiralp

Alan

Sili

et al. 2021

Cytometry Part B Clinical

View full text Add to dashboard Cite

Background A better understanding of innate and adaptive cells in COVID‐19 is necessary for the development of effective treatment methods and vaccines. Methods We studied phenotypic features of innate and adaptive immune cells, oxidative burst, phagocytosis, and apoptosis. One hundred and three patients with COVID‐19 were grouped according to their clinical features into the categories of mild (35%), moderate (40.8%), and severe (24.3%). Results Monocytes were CD16+ pro‐inflammatory monocytes and tended to shed their HLA‐DR, especially in severe cases (p < 0.01). Neutrophils were mature and functional, although a decline of their CD10 and CD16 was observed (p < 0.01). No defect was found in the reactive oxygen species production and their apoptosis. The percentage of natural killer cells was in the normal range, whereas the percentages of CD8+NK and CD56+T lymphocytes were found to be high (p < 0.01). Although the absolute numbers of all lymphocyte subsets were low and showed a tendency for a gradual decrease in accordance with the disease progression, the most decreased absolute number was that of B lymphocytes, followed by CD4+ T cells in the severe cases. The percentages of double‐negative T cells; HLA‐DR+CD3+ and CD28−CD8+ subsets were found to be significantly increased. Importantly, we demonstrated the increased baseline activation of caspase‐3 and increased lymphocyte apoptosis. Conclusion We suggest that SARS‐CoV‐2 primarily affects the lymphocytes and not the innate cells. The increased baseline activation of Caspase‐3 could make the COVID‐19 lymphocytes more vulnerable to cell death. Therefore, this may interrupt the crosstalk between the adaptive and innate immune systems.

show abstract

Section: Discussionmentioning

confidence: 99%

Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

Ekşioğlu-Demiralp

Alan

Sili

et al. 2021

Cytometry Part B Clinical

View full text Add to dashboard Cite

show abstract

“…Fiorenza et al [21] found that antituberculous therapy exerted a positive influence on reactive oxygen burst and phagocytosis, unless an increase on phagocytosis was less salient that one seen for respiratory burst.…”

Section: Discussionmentioning

confidence: 99%

Effect of antituberculous drugs on human polymorphonuclear leukocyte functions in vitro

Okuyan

İzzettin

Sancar

et al. 2005

International Immunopharmacology

View full text Add to dashboard Cite

“…For example, neutrophils produce the cytokine tumor-necrosis factor-alpha (TNF-α), which stimulates dendritic cells and macrophage differentiation and activation, a necessary response in TB infection [ 14 , 15 , 28 ]. Additionally, TNF-α is known to have a protective role against TB infection and play a major role in host defense against these intracellular pathogens, aiding in phagocytosis, the activation of T-cells, as well as granuloma formation [ 20 , 25 , 26 , 29 , 30 , 31 , 32 , 33 , 34 ]. In response to M. tb , neutrophils will also release the chemokine IL-8, which has a central role in leukocyte recruitment to areas of granuloma formation, as well as respiratory burst in neutrophils [ 35 , 36 , 37 , 38 , 39 ].…”

Section: Cytokines Modulating the Functions Of Neutrophilsmentioning

confidence: 99%

Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection

Warren

Teskey

Venketaraman

2017

JCM

View full text Add to dashboard Cite

Neutrophils have a significant yet controversial role in the innate immune response to Mycobacterium tuberculosis (M. tb) infection, which is not yet fully understood. In addition to neutrophils’ well-known effector mechanisms, they may also help control infection of M. tb through the formation of neutrophil extracellular traps (NETs), which are thought to further promote the killing of M. tb by resident alveolar macrophages. Cytokines such as IFN-γ have now been shown to serve an immunomodulatory role in neutrophil functioning in conjunction to its pro-inflammatory function. Additionally, the unique transcriptional changes of neutrophils may be used to differentiate between infection with M. tb and other bacterial and chronic rheumatological diseases such as Systemic Lupus Erythematosus. Adversely, during the innate immune response to M. tb, inappropriate phagocytosis of spent neutrophils can result in nonspecific damage to host cells due to necrotic lysis. Furthermore, some individuals have been shown to be more genetically susceptible to tuberculosis (TB) due to a “Trojan Horse” phenomenon whereby neutrophils block the ability of resident macrophages to kill M. tb. Despite these aforementioned negative consequences, through the scope of this review we will provide evidence to support the idea that neutrophils, while sometimes damaging, can also be an important component in warding off M. tb infection. This is exemplified in immunocompromised individuals, such as those with human immunodeficiency virus (HIV) infection or Type 2 diabetes mellitus. These individuals are at an increased risk of developing tuberculosis (TB) due to a diminished innate immune response associated with decreased levels of glutathione. Consequently, there has been a worldwide effort to limit and contain M. tb infection through the use of antibiotics and vaccinations. However, due to several significant limitations, the current bacille Calmette-Guerin vaccine (BCG, vaccine against TB) does not meet the criteria for universal utilization for all ages and populations across the globe. New research involving neutrophils has yielded a new vaccine called M. smegmatis-Ag85C-MPT51-HspX (mc2-CMX) that has been shown to elicit a humoral and cellular response against M. tb in mice that is superior to the BCG vaccine.

show abstract

Impaired neutrophil function in patients with pulmonary tuberculosis and its normalization in those undergoing specific treatment, except the HIV-coinfected cases

Cited by 11 publications

References 34 publications

Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

Peripheral innate and adaptive immune cells during COVID‐19: Functional neutrophils, pro‐inflammatory monocytes, and half‐dead lymphocytes

Effect of antituberculous drugs on human polymorphonuclear leukocyte functions in vitro

Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection

Contact Info

Product

Resources

About