Impaired Neutrophil Chemotaxis after Cardiac Surgery

Jensen, Rebekka Vibjerg; Storgaard, Merete; Vedelsdal, Rune; Obel, Niels

doi:10.3109/14017439509107216

Cited by 19 publications

(9 citation statements)

References 10 publications

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“…Furthermore, CD11b/ CD18 expression is directly related to plasma endotoxin levels after surgery [88]. Finally, isolated PMNs display depressed chemotactic responses in migration assays in vitro [13,92].…”

Section: Surgical Patientsmentioning

confidence: 99%

Neutrophil migration during endotoxemia

Wagner

Roth

1999

Journal of Leukocyte Biology

177

125

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Endotoxemia is marked by a global activation of inflammatory responses, which can lead to shock, multiple organ failure, and the suppression of immune and wound healing processes. Neutrophils (PMNs) play a central role in some of these responses by accumulating in tissues and releasing reactive oxygen species and proteases that injure host structures. This review focuses on altered PMN migratory responses that occur during endotoxemia and their consequences in the development of pulmonary infection. The inflammatory mediators that might be responsible for these altered responses are discussed. The oxidant potential of PMNs is increased after exposure to endotoxin both in vitro and during clinical and experimental endotoxemia. However, other functions such as chemotaxis and phagocytosis are often depressed in these same cells. Endotoxin exposure renders PMNs hyperadhesive to endothelium. The sum of these effects produces activated inflammatory cells that are incapable of leaving the vasculature. As such, the endotoxic PMN is more likely to promote tissue injury from within microvascular beds than to clear pathogens from extravascular sites. Moreover, the functional characteristics of endotoxic PMNs are similar to those observed during trauma, burn injury, sepsis, surgery, and other inflammatory conditions. Accordingly, several clinical conditions might have a common effector in the activated, yet migratorially dysfunctional, PMN. Direct effects of endotoxin on PMNs as well as effects of endogenous mediators released during endotoxemia are discussed. Understanding PMN behavior during endotoxemia may provide basic and critical insights that can be applied to a number of inflammatory scenarios. J. Leukoc. Biol. 66: 10-24; 1999.

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Section: Surgical Patientsmentioning

confidence: 99%

Neutrophil migration during endotoxemia

Wagner

Roth

1999

Journal of Leukocyte Biology

177

125

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“…Published sets from institutions that deal with concurrent operations of heart and lungs more widely have not been too large as well. They usually encompass about 10 patients (17,23,24). For the time being, in our department we don't routinely pursue combined anatomical resection planned lung outputs using median sternotomy.…”

Section: Resultsmentioning

confidence: 99%

“…The timing of surgical therapy in patients with both known lung cancer and cardiac disease has recently been a topical question (9,16,17,23). The number of such affected patients is increasing because both diseases have some common risk factors.…”

Section: Introductionmentioning

confidence: 99%

Possibilities of Combined Surgical Treatment of Lung Tumours and Heart Diseases

Habal

Šimek

Lonský

et al. 2006

Acta Med. (Hradec Kralove, Czech Repub.)

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The purpose of the study was a retrospective evaluation of the outcome of surgical therapy of lung cancer in patients where there was concomitant cardiac disease and who underwent a cardiac operation either because of ischemic heart disease or because of valvular disease. These patients were operated on at various time intervals (two to ten months) after their cardiac operation. Some patients had their lung cancer surgery after the cardiac operation because of the high risk of possible cardiac postoperative complications; in one patient the lung operation preceded the cardiac one.

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“…For decades, on-pump CABG has successfully treated CAD, and increased overall survival in some patients [3,84]. Performing on-pump CABG is known to stimulate perioperative proinflammatory mediators [85,86], which may contribute to the development of PPCs as well as other complications including neurologic dysfunction [87,88], renal dysfunction [89], and infections [90]. Reasons for this CABG-induced proinflammatory state may be related to the exposure to the extracorporal circuits with all the associated tubing and foreign material [85,86].…”

Section: Inflammation Cad Pulmonary Function and The Cardiac Surgimentioning

confidence: 99%

Inflammation Biomarkers as Predictors of Pulmonary Outcomes in Cardiac Surgical Patients

Sweiss¹,

Sawaqed²,

Leeper³

et al. 2013

OJTS

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Prolonged ventilator support, pulmonary infections and the need for tracheostomies after cardiac operations are associated with increased hospital mortality, length of stay, cost of hospitalization and reduced long term survival. The objective of this study is to review the literature and develop and present an understanding of the potential role of specific pre-operatively or intra-operatively collected inflammatory biomarkers and their role as predictors of pulmonary outcomes in cardiac surgery.

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Impaired Neutrophil Chemotaxis after Cardiac Surgery

Cited by 19 publications

References 10 publications

Neutrophil migration during endotoxemia

Neutrophil migration during endotoxemia

Possibilities of Combined Surgical Treatment of Lung Tumours and Heart Diseases

Inflammation Biomarkers as Predictors of Pulmonary Outcomes in Cardiac Surgical Patients

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