Impaired neuronal synchrony after focal ischemic stroke in elderly patients

Wu, Wenqing; Sun, Junfeng; Jin, Zheng; Guo, Xiaoli; Qiu, Yihong; Zhu, Yan; Tong, Shanbao

doi:10.1016/j.clinph.2010.06.003

Cited by 45 publications

(41 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So far the results are not absolutely consistent because of the high variance in patients, due in part to age, stroke severity, lesion site, and time of recovery. However, the most consistent finding was that stroke may lead to a reduction of brain connectivity, especially the inter-hemispheric interactions [19], [23], [26]- [28] and the intra-hemispheric interactions in the ipsilesional hemisphere [29]- [31]. On the other hand, there were also evidences of some compensational increase of connectivity.…”

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 92%

“…Relatively higher connectivity in the contralesional hemisphere was suggested by coherence analyses of EEG data recorded in well-recovered stroke patients [13]. The synchronization of EEG signals increased among intact areas in the ipsilateral hemisphere for unilateral stroke patients [19]. Higher functional connectivity with the ipsilesional frontal and parietal cortices, bilateral thalamus, and cerebellum was also demonstrated in stroke patients by fMRI [32].…”

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 95%

“…Post-stroke disruption of brain networks has been extensively studied by both neuroimaging [50], [51] and electrophysiological [19], [52] techniques. So far the results are not absolutely consistent because of the high variance in patients, due in part to age, stroke severity, lesion site, and time of recovery.…”

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 99%

“…Brain plasticity after ischemic stroke has been widely studied from the perspective of connectivity, especially in the motor network [22]- [25]. The findings can be summarized by two major patterns of changes after stroke: 1) reduced brain connectivity related to clinical deficits, especially the inter-hemispheric connections [19], [23], [26]- [28] and the intra-hemispheric connections in the ipsilesional hemisphere [29]- [31]; and 2) compensational enhanced connectivity contributed to functional recovery [13], [19], [32]. However, the detailed patterns depend greatly on the injury (e.g., lesion site and severity).…”

Section: Introductionmentioning

confidence: 99%

“…Various methods, such as coherence [12], [13], mutual information [14]- [16], partial directed coherence (PDC) [17], [18], and phase synchronization [19]- [21], have been applied to the quantification of neural connectivity between different brain regions using neuroimaging or electrophysiological techniques. Brain plasticity after ischemic stroke has been widely studied from the perspective of connectivity, especially in the motor network [22]- [25].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Enhanced Effective Connectivity in Mild Occipital Stroke Patients With Hemianopia

Guo

Jin²,

Feng

et al. 2014

IEEE Trans. Neural Syst. Rehabil. Eng.

Self Cite

View full text Add to dashboard Cite

Plasticity-based spontaneous recovery and rehabilitation intervention of stroke-induced hemianopia have drawn great attention in recent years. However, the underlying neural mechanism remains unknown. This study aims to investigate brain network disruption and reorganization in hemianopia patients due to mild occipital stroke. Resting-state networks were constructed from 12 hemianopia patients with right occipital infarct by partial directed coherence analysis of multi-channel electroencephalograms. Compared with control subjects, the patients presented enhanced connectivity owing to newly formed connections. Compensational connections mostly originated from the peri-infarct area and targeted contralesional frontal, central, and parietal cortices. These new ipsilesional-to-contralesional inter-hemispheric connections coordinately presented significant correlation with the extent of vision loss. The enhancement of connectivity might be the neural substrate for brain plasticity in stroke-induced hemianopia and may shed light on plasticity-based recovery or rehabilitation.

show abstract

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 92%

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 95%

Section: A Enhanced Connectivity After Occipital Strokementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enhanced Effective Connectivity in Mild Occipital Stroke Patients With Hemianopia

Guo

Jin²,

Feng

et al. 2014

IEEE Trans. Neural Syst. Rehabil. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

Coherent neural oscillations inform early stroke motor recovery

Cassidy

Wodeyar

Srinivasan

et al. 2021

Human Brain Mapping

View full text Add to dashboard Cite

Neural oscillations may contain important information pertaining to stroke rehabilitation. This study examined the predictive performance of electroencephalography‐derived neural oscillations following stroke using a data‐driven approach. Individuals with stroke admitted to an inpatient rehabilitation facility completed a resting‐state electroencephalography recording and structural neuroimaging around the time of admission and motor testing at admission and discharge. Using a lasso regression model with cross‐validation, we determined the extent of motor recovery (admission to discharge change in Functional Independence Measurement motor subscale score) prediction from electroencephalography, baseline motor status, and corticospinal tract injury. In 27 participants, coherence in a 1–30 Hz band between leads overlying ipsilesional primary motor cortex and 16 leads over bilateral hemispheres predicted 61.8% of the variance in motor recovery. High beta (20–30 Hz) and alpha (8–12 Hz) frequencies contributed most to the model demonstrating both positive and negative associations with motor recovery, including high beta leads in supplementary motor areas and ipsilesional ventral premotor and parietal regions and alpha leads overlying contralesional temporal–parietal and ipsilesional parietal regions. Electroencephalography power, baseline motor status, and corticospinal tract injury did not significantly predict motor recovery during hospitalization (R2 = 0–6.2%). Findings underscore the relevance of oscillatory synchronization in early stroke rehabilitation while highlighting contributions from beta and alpha frequency bands and frontal, parietal, and temporal–parietal regions overlooked by traditional hypothesis‐driven prediction models.

show abstract