“…Second, we conducted conventional TOI analyses using average individual values of WM parameters over the whole tract to allow comparison with previous literature (“average TOI analyses”) and to ensure continuity with previous analyses performed on data from the LFLSAD ( Bas-Hoogendam et al, 2018b ). That is, following methods previously described ( Bas-Hoogendam et al, 2018b , Bas-Hoogendam et al, 2019b , Bas-Hoogendam et al, 2020b , Bas‐Hoogendam et al, 2019a ), associations between individual average values of WM parameters (FA, MD, RD and AD over the whole tract) per tract and clinical symptoms of SAD (z-SA and FNE) were examined by performing multiple regression analyses using linear mixed models in R ( R Core Team, 2019 ). Average values of FA, AD, MD and RD were extracted for each individual unilaterally per tract.…”