Impaired myogenic response of the afferent arteriole contributes to the increased susceptibility to renal disease in Milan normotensive rats

Ge, Ying; Fan, Fan; Didion, Sean P.; Roman, Richard J.

doi:10.14814/phy2.13089

Cited by 13 publications

(11 citation statements)

References 42 publications

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“…The Milan normotensive strain has also recently proved useful for investigating genetic mechanisms mediating impaired myogenic responses and susceptibility to development of proteinuria and renal injury. 56…”

Section: Platforms Of Experimental Hypertension: Geneticmentioning

confidence: 99%

“…The various genetic rat strains can be used as models of slowly developing primary hypertension, 48,67,68 juvenile hypertension, 69,70 salt-induced hypertension, 51 and hypertension associated with end-organ damage. 56 However, understanding the genetic composition of the hypertensive strain and choosing an appropriate control strain are important. 66 A direct comparison of 2 strains of commonly used DSS rats demonstrated >1.3 million different base pairs (bps) between the strains and a significant difference in BP when the rats were fed a high-salt diet.…”

Section: Platforms Of Experimental Hypertension: Geneticmentioning

confidence: 99%

See 1 more Smart Citation

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman

Kurtz²,

Touyz³

et al. 2019

Hypertension

205

176

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Hypertension is the most common chronic disease in the world, yet the precise cause of elevated blood pressure often cannot be determined. Animal models have been useful for unraveling the pathogenesis of hypertension and for testing novel therapeutic strategies. The utility of animal models for improving the understanding of the pathogenesis, prevention, and treatment of hypertension and its comorbidities depends on their validity for representing human forms of hypertension, including responses to therapy, and on the quality of studies in those models (such as reproducibility and experimental design). Important unmet needs in this field include the development of models that mimic the discrete hypertensive syndromes that now populate the clinic, resolution of ongoing controversies in the pathogenesis of hypertension, and the development of new avenues for preventing and treating hypertension and its complications. Animal models may indeed be useful for addressing these unmet needs.

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Section: Platforms Of Experimental Hypertension: Geneticmentioning

confidence: 99%

Section: Platforms Of Experimental Hypertension: Geneticmentioning

confidence: 99%

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman

Kurtz²,

Touyz³

et al. 2019

Hypertension

205

176

View full text Add to dashboard Cite

show abstract

“…The auto-regulatory feedback mechanisms that maintain renal blood flow (RBF) and glomerular filtration rate (GFR) over a wide range of haemodynamic pathophysiological conditions can be disturbed in metabolic and inflammatory disease states promoting the progression of nephropathy [1][2][3]. Measuring and interpreting altered renal perfusion at baseline and in response to physiological stressors would facilitate assessment of individuals at risk of kidney disease or its complications, and assist in the development of pharmacological interventions [4].…”

Section: Introductionmentioning

confidence: 99%

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

et al. 2018

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Objectives We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantify renal perfusion (RBF), bolus arrival time (BAT) and tissue T 1 . Methods In a study approved by the Health Research Authority, 12 healthy volunteers (mean age, 27.6 ± 18.5 years; 5 male) gave informed consent for renal imaging at 3 T using multi-TI ASL and conventional single-TI ASL. Glyceryl trinitrate (GTN) was used as a vasodilator challenge in six subjects. Flow-sensitive alternating inversion recovery (FAIR) preparation was used with background suppression and 3D-GRASE (gradient and spin echo) read-out, and images were motion-corrected. Parametric maps of RBF, BAT and T 1 were derived for both kidneys. Agreement was assessed using Pearson correlation and Bland-Altman plots. Results Inter-study correlation of whole-kidney RBF was good for both single-TI (r 2 = 0.90), and multi-TI ASL (r 2 = 0.92). Single-TI ASL gave a higher estimate of whole-kidney RBF compared to multi-TI ASL (mean bias, 29.3 ml/min/100 g; p <0.001). Using multi-TI ASL, the median T 1 of renal cortex was shorter than that of medulla (799.6 ms vs 807.1 ms, p = 0.01), and mean whole-kidney BAT was 269.7 ± 56.5 ms. GTN had an effect on systolic blood pressure (p < 0.05) but the change in RBF was not significant. Conclusions Free-breathing multi-TI renal ASL is feasible and reproducible at 3 T, providing simultaneous measurement of renal perfusion, haemodynamic parameters and tissue characteristics at baseline and during pharmacological challenge. Key points • Multiple inversion time arterial spin labelling (ASL) of the kidneys is feasible and reproducible at 3 T.• This approach allows simultaneous mapping of renal perfusion, bolus arrival time and tissue T 1 during free breathing.• This technique enables repeated measures of renal haemodynamic characteristics during pharmacological challenge.

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“…RBF raised about 40%, whereas stop‐flow pressure only elevated by about 20% when renal perfusion pressure increased from 100 to 140 mmHg (Ge et al. ).…”

mentioning

confidence: 99%

“…A recent study by Ge et al. () provided a potential mechanism for the difference in diabetes‐associated kidney injury between MNS and MHS rats. They demonstrated that normotensive rats with impaired autoregulation developed severe diabetic kidney injury, in contrast, the hypertensive rats with intact autoregulation were protected from diabetic kidney injury.…”

mentioning

confidence: 99%

The real culprit behind diabetic nephropathy: impaired renal autoregulation?

Liu

2017

Physiological Reports

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Impaired myogenic response of the afferent arteriole contributes to the increased susceptibility to renal disease in Milan normotensive rats

Cited by 13 publications

References 42 publications

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Motion-corrected multiparametric renal arterial spin labelling at 3 T: reproducibility and effect of vasodilator challenge

The real culprit behind diabetic nephropathy: impaired renal autoregulation?

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