Impaired myocardial performance and response to calcium in experimental alcoholic cardiomyopathy

Kino, Masaya; Thorp, K; Bing, O.; Abelmann, Walter H.

doi:10.1016/0022-2828(81)90473-9

Cited by 37 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the inotropic response to isoproterenol was attenuated in the EtOH atria. These findings are similar to those of others in whole heart (Segel, 1987), atrium (Baker et al, 1987), and papillary (Kino et al, 1981) preparations. We have also reported that a shorter duration of alcohol consumption (2-3 months) was associated with depressed contractile force and myofilament sensitivity to calcium, in addition to reduced responsiveness to various inotropic agents .…”

Section: Discussionsupporting

confidence: 94%

“…Collectively, the majority of reports indicate that long-term alcohol consumption is associated with LV dilation (Fauchier et al, 2000;Lazarevic et al, 2000;Matthews et al, 1981;Urbano-Marquez et al, 1989). Others have also found an increase in LV mass and posterior wall thickness (Askanas et al, 1980;Kino et al,1981;Lazarevic et al, 2000;Matthews et al, 1981). In the present study, we found a trend for increased LV mass after 8 months of alcohol consumption and a further, significant increase was found after 12 months of alcohol consumption.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

Kim

Beck

Bieniarz

et al. 2001

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 69%

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

Kim

Beck

Bieniarz

et al. 2001

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…Several studies have shown that rats chronically treated with ethanol have impaired cardiac muscle contractility (Segel et al, 1975;Kino et al, 1981;Preedy and Peters, 1989;Capasso et al, 1992). Measurement of developed isometric tension in papillary muscles dissected from the hearts of rats fed ethanol for periods of 5 weeks to several months, generally demonstrates significant reductions in one or more indices of mechanical performance (Segel et al, 1975;Kino et al, 1981;Tepper et al, 1986). By contrast, Capasso et al (1992) reported that, in the papillary muscle, no difference in isometric developed tension was found between controls and ethanol-treated rats when either the left or right side was compared.…”

Section: Discussionmentioning

confidence: 99%

Long-term voluntary ethanol consumption induces impairment of the mechanical performance in the papillary muscle of Sardinian alcohol-preferring rats

Licheri

Vargiu²,

Fadda³

et al. 2001

Alcohol and Alcoholism

View full text Add to dashboard Cite

The effects of chronic (26 weeks) ethanol consumption on cardiac muscle contractility in Sardinian alcohol-preferring drinkers (sP-D) and Sardinian alcohol-preferring naive (sP-N) rats were investigated. Experiments were carried out 1 week after ethanol administration ceased. Length-tension and force-frequency responses in left ventricular papillary muscles from both sP-D and sP-N rats were recorded in vitro. Papillary muscles were gradually stretched in steps of 5% of the reference (initial) length (L(r)) from 100 to 130% L(r). In sP-D rats, length-tension relationships showed a significant reduction in active tension: at optimal length for maximum active tension (130% L(r)), the developed force value (1.38 +/- 0.36 mN/mg, dry tissue) was 54% lower than that found in sP-N rats (3.16 +/- 0.6 mN/mg, dry tissue). In sP-D papillary muscles, a decrease in contractile behaviour was also observed in force-frequency responses (0.03-120 pulse/min), when compared with sP-N rats; developed force was found to be reduced by about 2.5 times. These results indicate that long-term ethanol consumption impairs the mechanical performance of sP papillary muscle, inducing a negative inotropic effect.

show abstract

“…Although the association of chronic alcohol intake and heart disease is generally accepted (1)(2)(3)(4), the exact mechanism of the alterations and their relationship to metabolic changes in the myocardium are as yet unknown. The effect of alcohol on heart mitochondrial function was emphasized by the diminution in respiratory function (5,6), decreased activity of citric acid cycle enzymes in experimental alcoholic heart disease (AHD) (6,7) or in patients with AHD (8) and by morphologically altered mitochondria (9,10).…”

Section: Introductionmentioning

confidence: 98%

The effects of chronic ethanol treatment on oligomycin sensitive ATPase activity in the guinea pig heart

1985

View full text Add to dashboard Cite

In an effort to determine the effect of chronic ethanol ingestion on myocardial oligomycin sensitive ATPase, guinea pigs were fed 15% ethanol instead of drinking water for 34 weeks. Mg2+-ATPase activity of isolated mitochondria was determined in control and alcohol fed guinea pigs at 16, 20, 24 and 34 weeks. To prove a possible higher fragility of the mitochondria from alcohol fed animals, the ATPase activity was also determined in the supernatant after the isolation of mitochondria "100 000 g fraction". Mg2+-ATPase activity of the isolated mitochondria was time dependent reduced to 56% of the value obtained in the control animals. In the "100 000 g fraction" the ATPase activity, however, started to increase after 8 weeks and after 34 weeks it was about twice as high than in the control group. The findings of this study document a decrease in oligomycin sensitive ATPase activity and an increase in mitochondrial fragility after chronic ethanol ingestion. It supports in the thesis that chronic alcohol intake affects the activity of the intrinsic membrane enzymes by structural derangements of mitochondrial membrane. The changes may play a role in the development of alcoholic cardiomyopathy.

show abstract

Impaired myocardial performance and response to calcium in experimental alcoholic cardiomyopathy

Cited by 37 publications

References 23 publications

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

A Rodent Model of Alcoholic Heart Muscle Disease and Its Evaluation by Echocardiography

Long-term voluntary ethanol consumption induces impairment of the mechanical performance in the papillary muscle of Sardinian alcohol-preferring rats

The effects of chronic ethanol treatment on oligomycin sensitive ATPase activity in the guinea pig heart

Contact Info

Product

Resources

About