Impaired Myocardial Functional Reserve in Hypertension and Diabetes Mellitus Without Coronary Artery Disease: Searching for the Possible Link With Congestive Heart Failure in the Myocardial Doppler in Diabetes (MYDID) Study II

Shim

et al. 2011

Heart

Section: Discussionmentioning

confidence: 73%

Impact of left ventricular longitudinal diastolic functional reserve on clinical outcome in patients with type 2 diabetes mellitus

Shim

et al. 2011

Heart

“…Assessment of myocardial strain and SR has been used to identify early systolic impairment in arterial hypertension [89], asymptomatic mitral regurgitation [90], pulmonary hypertension [91], rejection after HTX [92], congenital cardiac abnormalities [93], obesity [94], subclinical atherosclerosis [95], and in a number of systemic diseases [96,97]. Strain can discriminate between hypertensive cardiomyopathy and nonobstructive hypertrophic cardiomyopathy [98].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Echocardiography in the assessment of left ventricular longitudinal systolic function: current methodology and clinical applications

et al. 2009

Quantification of left ventricular (LV) systolic function represents a major aspect of echocardiographic assessment in the spectrum of cardiac diseases. However, because of the high complexity of LV contraction mechanics, the classical approach with assessment of a single measure of systolic function, such as ejection fraction or fractional shortening, has been largely superseded. During the last years, through the considerable technical advances in the field of ultrasonography, a number of different echocardiographic methodologies have become available to perform a detailed assessment of different aspects of LV contraction. In particular, evaluation of LV longitudinal systolic dynamics has progressively gained importance as a key aspect in the assessment of LV systolic function. For most of the techniques currently used to explore LV longitudinal function, the clinical usefulness in both research and daily practice has been validated by consistent evidence and their use is rapidly increasing. Technical considerations and potential clinical applications of the assessment of LV longitudinal systolic function are reviewed.

Progress in Cardiovascular Diseases

“…However, there may be diabetes-specific accelerated forms of atherosclerosis with enhanced thrombogenicity (57). In the literature, a case is being made for the existence of a distinct form of cardiac dysfunction that has been termed "diabetic cardiomyopathy" (58,59). A universal finding among diabetics is a high prevalence of abnormal prolongation of the corrected QT (QTc) interval from the ECG (60).…”

Section: Diabetes As a Potential Predictor Of Sudden Cardiac Death Riskmentioning

confidence: 99%

Epidemiology of Sudden Cardiac Death: Clinical and Research Implications

Chugh

Reinier

Teodorescu

et al. 2008

597

458

The current annual incidence of sudden cardiac death in the US is likely to be in the range of 180-250,000 per year. Coinciding with the decreased mortality from coronary artery disease, there is evidence pointing toward a significant decrease in rates of sudden cardiac death in the US during the second half of the twentieth century. However the alarming rise in prevalence of obesity and diabetes in the first decade of the new millennium both in the US and worldwide, would indicate that this favorable trend is unlikely to persist. We are likely to witness a resurgence of coronary artery disease and heart failure, as a result of which sudden cardiac death will have to be confronted as a shared and indiscriminate, worldwide public health problem. There is also increasing recognition of the fact that discovery of meaningful and relevant risk stratification and prevention methodologies will require careful prospective community-wide analyses, with access to large archives of DNA, serum and tissue that link with well-phenotyped databases. The purpose of this review is to summarize current knowledge of sudden cardiac death epidemiology. We will discuss the significance and strengths of community-wide evaluations of sudden cardiac death, summarize recent observations from such studies, and finally highlight specific potential predictors that warrant further evaluation as determinants of sudden cardiac death in the general population.