Impaired Myocardial Function in Hypertrophic Cardiomyopathy

Saccheri, María Cristina; Cianciulli, Tomás Francisco; Lax, Jorge A.; Guerra, Juan E.; Redruello, Héctor Jorge; Glogier, Fabio L. Weich; Gagliardi, Juan; Dorelle, Adriana N.; Prezioso, Horacio A.; Vidal, Luis Alfonso

doi:10.1111/j.1540-8175.2008.00871.x

Cited by 12 publications

(15 citation statements)

References 18 publications

(39 reference statements)

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“…According to previous studies, IVRT is prolonged in HCM patients, particularly in the septal mitral annulus, and regional differences in relaxation abnormalities in HCM patients have already been reported by others. In line with our data, Saccheri et al described a septal pronounced decrease of E′ in HCM patients compared with healthy individuals. Further, heterogeneous IVRT intervals both in patients with HCM as well as in AHT were reported by Nunez et al However, we could not find any septal‐to‐lateral differences for E′, E/E′, and E′/A′ among different entities of LVH.…”

Section: Discussionsupporting

confidence: 93%

Early segmental relaxation abnormalities in hypertrophic cardiomyopathy for differential diagnostic of patients with left ventricular hypertrophy

Voigt¹,

Münch²,

Avanesov

et al. 2017

Clinical Cardiology

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Background Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric left ventricular hypertrophy (LVH). However, clinical signs can be subtle and differentiation from other causes of LVH is challenging. Hypothesis As diastolic dysfunction (DD) is an early sign in HCM, we aimed to find regional changes in relaxation pattern for differentiation from other entities of LVH. Methods In 148 patients (81 HCM, 55 arterial hypertension (AHT), 12 Fabry disease) and 63 healthy controls, relaxation patterns were assessed using regional tissue Doppler imaging. In 42 HCM patients, myocardial mass and fibrosis were quantified by cardiac magnetic resonance imaging and correlated with relaxation parameters. Results In HCM the septal to lateral isovolumic relaxation time (s/l IVRT) ratio was higher (1.5 ± 0.4) compared with AHT (1.1 ± 0.2), Fabry disease (1.0 ± 0.1), and controls (1.1 ± 0.2; P < 0.001), showing 77% sensitivity and 79% specificity to discriminate HCM‐related LVH from other entities. The s/l IVRT ratio was independent of global DD in HCM (HCM with DD: 1.5 ± 0.5, n = 52; HCM without DD: 1.5 ± 0.3, n = 29) and remained significantly different from other entities in a subgroup of HCM patients with maximum wall thickness < 20 mm (s/l ratio: 1.5 ± 0.5, n = 28). Regional IVRT did not correlate with the corresponding segmental myocardial mass or amount of fibrosis in cardiac magnetic resonance imaging. Conclusions HCM patients show a prolonged septal IVRT irrespective of the extent of LVH and even before developing global DD. The s/l IVRT ratio is significantly higher in HCM compared with AHT or Fabry disease, thus establishing segmental IVRT analysis as a potential parameter for differential diagnosis in LVH.

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Section: Discussionsupporting

confidence: 93%

Early segmental relaxation abnormalities in hypertrophic cardiomyopathy for differential diagnostic of patients with left ventricular hypertrophy

Voigt¹,

Münch²,

Avanesov

et al. 2017

Clinical Cardiology

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“…Interestingly, the present study showed decreased strain in both hypertrophied and nonhypertrophied regions, a finding in accordance with studies in humans 50,68,69 . Hence, strain analysis appears to be a more sensitive index of myocardial function than standard LV function assessment, emphasizing the diffuse nature of the disease 50,61,63,70 . The reduction in systolic strain correlates with the degree of concentric hypertrophy in a linear fashion.…”

Section: Discussionsupporting

confidence: 92%

Assessment of Left Ventricular Systolic Function by Strain Imaging Echocardiography in Various Stages of Feline Hypertrophic Cardiomyopathy

Wess

Sarkar

Hartmann

2010

Journal of Veterinary Internal Medicine

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Background: Diastolic dysfunction occurs in many cats with hypertrophic cardiomyopathy (HCM). Less is known about systolic function in various stages of HCM. Myocardial strain analysis by tissue Doppler imaging (TDI) is a noninvasive echocardiographic method to assess systolic function that has not been reported previously in cats.Objectives: To evaluate systolic function in various stages of feline HCM by measurement of myocardial strain. Animals: Two hundred and sixty-three cats. Methods: Cats were classified by echocardiography into one of the following groups: clinically healthy (control) group (n 5 160), mild HCM (n 5 22), moderate HCM (n 5 39), and severe HCM (n 5 42). Peak myocardial strain, measured by TDI in the basal and midventricular segment of the interventricular septal wall (IVS) and the left ventricular posterior wall (LVPW), was compared among different HCM and control groups.Results: Whereas conventional echocardiography demonstrated an apparently normal or supernormal contractile state based on percentage of fractional shortening, myocardial strain in all HCM groups was significantly decreased compared with the control group (P o .001). There was a significant correlation between strain values and wall thickness (P o .001). Reproducibility of strain analysis was 6.3% in the IVS and 9.7% in the LVPW.Conclusions and Clinical Importance: Myocardial strain analysis is a new, valuable, and reproducible method in cats. This method allows noninvasive detection of abnormal systolic deformation in cats with HCM despite apparently normal left ventricular systolic function as assessed by conventional echocardiography. The abnormal systolic deformation already was present in mild HCM and increased with progressive left ventricular concentric hypertrophy.

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“…Also, LV hypertrophy was related to increased total plasma volume in patients with PV 16 . Previous studies demonstrated negative effects of LV hypertrophy on LV functions by conventional and tissue Doppler echocardiography in various circumstances 17–19 . In addition, a positive and significant correlation of increased LV mass with myocardial dysfunction was demonstrated in the literature 20,21 .…”

Section: Discussionmentioning

confidence: 88%

Assessment of Left Ventricular Myocardial Performance by Tissue Doppler Echocardiography in Patients with Polycythemia Vera

Kayrak¹,

Acar

Gül³

et al. 2011

Echocardiography

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Impaired Myocardial Function in Hypertrophic Cardiomyopathy

Cited by 12 publications

References 18 publications

Early segmental relaxation abnormalities in hypertrophic cardiomyopathy for differential diagnostic of patients with left ventricular hypertrophy

Early segmental relaxation abnormalities in hypertrophic cardiomyopathy for differential diagnostic of patients with left ventricular hypertrophy

Assessment of Left Ventricular Systolic Function by Strain Imaging Echocardiography in Various Stages of Feline Hypertrophic Cardiomyopathy

Assessment of Left Ventricular Myocardial Performance by Tissue Doppler Echocardiography in Patients with Polycythemia Vera

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