Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation

Shim, Jaemin; Park, Jae Hyung; Kim, Jong Youn; Kim, Sook Kyoung; Joung, Boyoung; Lee, Moon Hyoung; Kim, Young Hoon; Pak, Hui Nam

doi:10.1016/j.ijcard.2011.05.064

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…Previous studies investigating the inflammatory changes following RFA have reported increased levels of IL-6, Tn-I and CRP indicating an increased systemic inflammatory activity (5,6,(10)(11)(12). We have also found an increase in IL-6 and CRP levels following RFA, but these increases did not reach statistical significance possibly due to the small sample size of our study.…”

Section: Discussioncontrasting

confidence: 91%

“…Up to now, studies evaluating stem cell mobilization and inflammatory changes following RFA have included patients that received long-lasting RF application (particularly AF patients) (5,6,(10)(11)(12). In our study, nearly all patients had an RFA duration of <5 minutes.…”

Section: Discussionmentioning

confidence: 98%

“…Although Cangiano et al have demonstrated that SDF-1α level was correlated with the increase in CD34+ stem cells following RFA, other studies did not reveal such an association (5,6,10). Kim et al have shown that the increase in CD34+ cell count following RFA was associated with MMP-9 and GROβ levels (5).…”

Section: Discussionmentioning

confidence: 99%

“…Kim et al have concluded that cardiac injury caused by RFA mobilizes CD34+ cells to the peripheral blood through a non-SDF-1a pathway associated with MMP-9 and GROβ (5). In a further study by the same group, Shim et al have revealed that the increase in post-RFA CD34+ cell count was more prominent in patients who underwent RF application for longer than 80 minutes (10). They have also shown that the change in CD34+ cell count was linearly correlated with the plasma Tn-I levels and associated with the procedural outcome following AF ablation (11).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Radiofrequency Ablation on Stem Cells and Systemic Inflammation in Patients with Supraventricular Tachycardia

Sertdemi̇r

Erdoğan²,

Feyzioğlu³

et al. 2019

std

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Amaç: Kemik iliğinde bulunan kök hücreler, doku onarımını artırmak için miyokardiyal hasar sonrası dolaşıma salınmaktadır. Başta atriyal fibrilasyon olmak üzere; kardiyak aritmilerin radyofrekans ile ablasyonu sonrası dolaşımda bulunan kök hücrelerin inflamatuar aracılar vasıtasıyla salınımının tetiklendiği gösterilmiştir. Bizim çalışmamızda, yavaş yol veya aksesuar yol gibi geniş olmayan ablasyon işlemlerinden sonra dolaşımdaki kök hücre sayısının artıp artmadığı araştırılmıştır. Hastalar ve Yöntem: 26 hastaya [yaş 54 (18-74)] radyofrekans ablasyon işlemi uygulandı. Bu hastalardan 18'ine atriyoventriküler nodal reentran taşikardi nedeniyle yavaş yol ablasyonu; 8'ine ise atriyoventriküler reentran taşikardi nedeniyle aksesuar yol ablasyonu yapıldı. Hastalarda periferik dolaşımdan alınan kan örneklerinde işlem öncesi ve işlem sonrası 7. ve 30. günlerde CD34+ hücre sayıları ve çeşitli serolojik belirteçlerin [Troponin-I (Tn-I), interlökin-6 (IL-6), Stromal deriveted faktör 1-α (SDF 1-α) ve C-reaktif protein (CRP)] düzeyleri incelendi. Bulgular: CD34+ hücrelerin, işlem sonrası 7. günde bazal ölçüme gore anlamlı artış gösterdiği [33 (15-133) vs. 22,5 (5-79) hücre/mikrolitre sırasıyla, P<0.001] ve 30. günde bazal seviyelere indiği gözlendi. Ablasyon sonrası Tn-I, CRP, IL-6 ve SDF1-α düzeylerinde istatiksel anlamlı artış izlenmedi. İşlem sırasında uygulanan enerji miktarı (watt) ile işlem sonrası 30. günde artan CD34+ hücreleri arasında doğru orantı izlendi (r: 0.460; p= 0.018). Sonuç: Çalışmamızda periferik kanda bulunan kök hücrelerin atriyal fibrilasyon ablasyonundan daha az enerji uygulanan yavaş yol veya aksesuar yol ablasyonundan sonrası 7. günde anlamlı şekilde arttığı ve izlemde 30. günde bazal seviyelerine döndüğü gösterilmiştir. Ayrıca, dolaşımda bulunan kök hücrelerdeki artışın işlem sırasında uygulanan eneji miktarı ile doğru orantılı olduğu da bulunmuştur.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The Effect of Radiofrequency Ablation on Stem Cells and Systemic Inflammation in Patients with Supraventricular Tachycardia

Sertdemi̇r

Erdoğan²,

Feyzioğlu³

et al. 2019

std

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“… 6–8 10–13 Therefore, we need to find better methods of attaining durable PVI, rather than ablating more. Other biological factors that potentially contribute to conduction recovery, such as haematopoietic progenitor cell mobilisation 29 30 or myofibroblasts, 31 should be considered in the future. Another point we need to consider is the definition of recurrence after AF catheter ablation.…”

Section: Discussionmentioning

confidence: 99%

Does additional linear ablation after circumferential pulmonary vein isolation improve clinical outcome in patients with paroxysmal atrial fibrillation? Prospective randomised study

Mun

Joung

Shim

et al. 2012

Heart

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ObjectiveCircumferential pulmonary vein isolation (CPVI) has been considered the cornerstone of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF). However, it is unclear whether linear ablation in addition to CPVI improves clinical outcome.DesignProspective randomised study to compare the efficacy of CPVI and CPVI with additional linear ablation in patients with paroxysmal AF (PAF).SettingUniversity hospital.PatientsThis study enrolled 156 patients (male 76.3%, 55.8±11.5 years old (mean±SD)) who underwent RFCA for PAF.InterventionsCPVI (n=52), CPVI+roof line (CPVI+RL; n=52) and CPVI+RL+posterior inferior line (CPVI+PostBox; n=52).Main outcome measuresProcedure time, ablation time and clinical outcome.Results(1) The CPVI group showed shorter total procedure time (180.4±39.5 min vs 189.6±29.0 min and 201.7±51.7 min, respectively (mean±SD); p=0.035) and ablation time (4085.5±1384.1 s vs 5253.5±1010.9 s and 5495.0±1316.0 s, respectively; p<0.001) than the CPVI+RL and CPVI+PostBox groups. (2) During 15.6±5.0 months of follow-up, the recurrence rates 3 months after RFCA were 11.5% in CPVI, 21.2% in CPVI+RL and 19.2% in CPVI+PostBox (p=0.440). (3) The achievement rate of CPVI was 100.0%, and bidirectional block rate was 80.8% in CPVI+RL and 59.6% in CPVI+PostBox. The clinical recurrence rates with or without achieving bidirectional block were not significantly different from each other (p=0.386).ConclusionIn patients with PAF, linear ablation in addition to CPVI did not improve clinical outcome, regardless of bidirectional block achievement, while it prolonged the total procedure and ablation time.

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The Blinding Period Following Ablation Therapy for Atrial Fibrillation

Gottlieb

Dekker

Coronel

2021

JACC: Clinical Electrophysiology

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Impaired mobilization of bone marrow derived CD34 positive mononuclear cells is related to the recurrence of atrial fibrillation after radiofrequency catheter ablation

Cited by 7 publications

References 29 publications

The Effect of Radiofrequency Ablation on Stem Cells and Systemic Inflammation in Patients with Supraventricular Tachycardia

The Effect of Radiofrequency Ablation on Stem Cells and Systemic Inflammation in Patients with Supraventricular Tachycardia

Does additional linear ablation after circumferential pulmonary vein isolation improve clinical outcome in patients with paroxysmal atrial fibrillation? Prospective randomised study

The Blinding Period Following Ablation Therapy for Atrial Fibrillation

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