Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia

Brockhaus-Dumke, Anke; Tendolkar, Indira; Pukrop, Ralf; Schultze‐Lutter, Frauke; Klosterkötter, Joachim; Ruhrmann, Stephan

doi:10.1016/j.schres.2004.05.016

Cited by 140 publications

(113 citation statements)

References 32 publications

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“…45 As standard stimuli, 1560 tones (80% of all stimuli) at a pitch of 1000 Hz and a duration of 80 ms were presented via earphones at 75 dB SPL (closed system headphones, Sennheiser, HAD 200). Occasionally, 1 of 2 different deviant stimuli was presented.…”

Section: Stimulimentioning

confidence: 99%

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

Thiebes

Leicht

Ćurić

et al. 2017

JPN

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Section: Stimulimentioning

confidence: 99%

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

Thiebes

Leicht

Ćurić

et al. 2017

JPN

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“…Like PPI, MMN is presumed to reflect a predominantly automatic, preconscious process-in this case, one of detecting a 'mismatch' between the deviant stimulus and a sensory-memory trace (Näätänen et al, 1989). MMN amplitude reduction in schizophrenia was reported over 20 years ago (Shelley et al, 1991) with subsequent studies consistently identifying deficits in chronic and unmedicated patients Bodatsch et al, 2011;Brockhaus-Dumke et al, 2005;Light & Braff, 2005;Kirino & Inoue 1999;Catts et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Memantine Effects On Sensorimotor Gating and Mismatch Negativity in Patients with Chronic Psychosis

Swerdlow

Bhakta

Chou

et al. 2015

Neuropsychopharmacol

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Patients with chronic psychotic disorders (CPD) exhibit deficient sensorimotor gating (measured by prepulse inhibition (PPI) of startle) and mismatch negativity (MMN). In healthy subjects (HS), N-methyl-D-aspartate (NMDA) antagonists like memantine and ketamine increase PPI, and under some conditions, memantine enhances MMN; these findings present a challenge to understanding the basis for deficient PPI and MMN in psychotic disorders, as reduced NMDA activity is implicated in the pathogenesis of these disorders. Here we assessed for the first time the effects of memantine on PPI and MMN in CPD subjects. Baseline PPI was measured in HS and patients with a diagnosis of schizophrenia or schizoaffective disorder, depressed type. Subjects (total n = 84) were then tested twice, in a double-blind crossover design, comparing either: (1) placebo vs 10 mg of memantine or (2) placebo vs 20 mg memantine. Tests included measures of acoustic startle magnitude and habituation, PPI, MMN, autonomic indices, and subjective self-rating scales. Memantine (20 mg) significantly enhanced PPI in CPD subjects, and enhanced MMN across subject groups. These effects on PPI were age dependent and most evident in older CPD patients, whereas those on MMN were most evident in younger subjects. The lower dose (10 mg) either had no detectable effect or tended to degrade these measures. The NMDA antagonist, memantine, has dose-dependent effects on preconscious, automatic measures of sensorimotor gating and auditory sensory processing that are associated with enhanced cognition and function in CPD patients. Ongoing studies will determine whether these memantine-induced changes predict acute pro-cognitive or otherwise clinically beneficial effects in CPD patients.

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“…Deficits in early auditory sensory processing, including N1, MMN, and P300, have been shown using ERP in schizophrenic subjects (Baldeweg et al, 2004;Kasai et al, 2002;Salisbury et al, 1998;Javitt et al, 2000;Javitt et al, 1995;Elvevag et al, 2004), in prodromal subjects (Brockhaus-Dumke et al, 2005), and in SPD subjects (Salisbury et al, 1996;Niznikiewicz et al, 2000;Liu et al, 2007). Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007). Indeed, ERP has certain advantages in testing auditory sensory processing in that tones can be played in sound-proof laboratories with little to no extraneous noise, experimental design allows for a large number of deviants, greater than 160 in most studies (Shelley et al, 1991;Javitt et al, 1995;Umbricht et al, 1998;Michie et al, 2000;Baldeweg et al, 2004;Brockhaus-Dumke et al, 2005) (exception, Kirino and Inoue, 1999) and allows for precise time recordings on the order of milliseconds at the expense of poor spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

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Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

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Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia

Cited by 140 publications

References 32 publications

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans

Memantine Effects On Sensorimotor Gating and Mismatch Negativity in Patients with Chronic Psychosis

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

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