Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients

Klonizakis, Markos; Tew, Garry A.; Michaels, Jonathan; Saxton, John

doi:10.1016/j.mvr.2008.09.009

Cited by 28 publications

(25 citation statements)

References 27 publications

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“…Participants with past venous ulceration, lower-limb arterial disease, hypercholesterolemia, peripheral oedema or cardiac failure, and those with major skin changes in the gaiter area were excluded as well as those who take any form of regular exercise. This choice ensured that all participants were similar in age to groups that we have previously studied [34,35] to allow inter-study comparisons. Participants were also asked to refrain from any regular or structured exercise activities outside their supervised exercise sessions, undertaken for the purposes of the study.…”

Section: Participantsmentioning

confidence: 99%

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Alkhatib

Klonizakis

2014

Clinical Hemorheology and Microcirculation

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This study tested the potential risk-reduction benefits of Mediterranean Diet (MD) and regular exercise training on microvascular activity and cardiorespiratory capacity in postmenopausal women. Fifteen sedentary postmenopausal participants (age = 54.6 ± 3.6) were randomised into either exercise training or exercise combined with following MD for eight-weeks, and were assessed for their cardiorespiratory capacity, and upper-and lower-limb endothelial cutaneous vascular conductance (CVC) test using Laser Doppler Fluximetry (LDF), coupled with measuring endothelium-dependent Acetylcholine Chloride (Ach) and -dependent Sodium Nitropurruside (SNP) vasodilators. Exercise training improved cardiorespiratory capacity as indicated by ventilatory threshold (11.5 ± 2.1 vs. 14.0 ± 3.0 ml·kg −1 ·min −1 , p < 0.05) and improved the microcirculatory perfusion results of CVC for both vasodilators Ach (p < 0.001, d = 0.65) and SNP (p = 0.003, d = 0.53) in the lower-limb and ACh (p = 0.01, d = 0.41) and SNP (p = 0.03, d = 0.48) in the upper-limb, all (p < 0.05). However, combining exercise with MD showed a stronger improvement in Ach (p = 0.02, d = 0.36) of the lower limb, than in exercise alone group. The results suggest that regular moderate exercise improves microcirculatory vascular function and increases exercise tolerance, both are responsible for reducing cardiovascular risk in postmenopausal women. However, combining MD with exercise suggests additional microvascular vasodialiatory improvement, suggesting an effective strategy for further cardiovascular risk-reduction in this high-risk group.

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Section: Participantsmentioning

confidence: 99%

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Alkhatib

Klonizakis

2014

Clinical Hemorheology and Microcirculation

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“…Drug iontophoresis was performed using a technique described previously (Klonizakis et al 2009). Briefly, preparations of acetylcholine (ACh; Miochol-E, Novartis, Switzerland) and sodium nitroprusside (SNP; Fagron, The Netherlands) were placed in the drug delivery electrodes of the iontophoresis probes, which were attached to an iontophoresis controller (PeriIont PF382b; Perimed AB).…”

Section: Participantsmentioning

confidence: 99%

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

2010

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The impact of cardiopulmonary fitness (VO(2max)) on the age-related decline in skin-microvessel vasodilator function has not been fully established and the inter-relationships among different measures of microvascular vasodilator function are unknown. We used laser Doppler flowmetry to assess relative changes in forearm skin blood flow to various stimuli in three groups of adults: young (n = 15; 27 +/- 2 years), older sedentary (n = 14; 65 +/- 6 years) and older fit (n = 15; 61 +/- 5 years). Local-heating induced and post-occlusive hyperaemia responses were higher in the young and older fit groups compared to the older sedentary group (P < 0.05) and were moderately correlated with VO(2max) in the pooled cohort of older adults (r = 0.49-0.58; P < 0.05). Peak hyperaemia responses to acetylcholine and sodium nitroprusside were higher in young compared to older sedentary adults (P < 0.05) and were not associated with VO(2max) in older adults (P > 0.05). Associations among different measures of microvascular vasodilator function were generally moderate at best. In summary, the local heating and reactive hyperaemia data indicate that the age-related decline in skin-microvessel vasodilator function can be ameliorated through regular aerobic exercise training. As this is not supported by the iontophoresis data, we recommend that, when assessing microvascular function, the use of a single physiological or pharmacological stimulation coupled to laser Doppler flowmetry should be avoided. Finally, the moderate correlations between outcomes probably reflect the distinct mediators that are responsible for the vasodilator response to each test.

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“…muscarinic receptors; vasodilation; genetically altered mice ACETYLCHOLINE IS A POWERFUL dilator of most vascular beds and a major diagnostic and investigative tool for the assessment of endothelial function (15,24,42). Its activity is mediated by endothelial muscarinic receptors triggering the release of the actual vasorelaxing agents, such as nitric oxide (NO) (19,26).…”

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confidence: 99%

Role of M₁, M₃, and M₅ muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

Gericke

Sniatecki

Mayer

et al. 2011

American Journal of Physiology-Heart and Circulatory Physiology

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Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients

Abstract: Original article can be found at: http://www.sciencedirect.com/science/journal/00262862 Copyright Elsevier Inc. DOI: 10.1016/j.mvr.2008.09.00

Cited by 28 publications

References 27 publications

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

Role of M₁, M₃, and M₅ muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

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Impaired microvascular endothelial function is restored by acute lower-limb exercise in post-surgical varicose vein patients

Abstract: Original article can be found at: http://www.sciencedirect.com/science/journal/00262862 Copyright Elsevier Inc. DOI: 10.1016/j.mvr.2008.09.00

Cited by 28 publications

References 27 publications

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women

Effects of ageing and fitness on skin-microvessel vasodilator function in humans

Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

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Role of M₁, M₃, and M₅ muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice