Impaired mesial synchronization in temporal lobe epilepsy

Hyper-Synchronization, De-Synchronization, Synchronization and Seizures

“…However, causality may also be reversed in the sense that an already present desynchronization may be the cause of the seizure spreading (Schindler et al, 2007). This interpretation is supported by recent findings (Ortega et al, 2010) in TLE, where there exists an intrinsic imbalance in the synchronized activity between both temporal lobes, being the ipsilateral lobe more desynchronized than the contralateral one.…”

“…The whole same procedure is able to be extended in the case of synchronization between time series. When dealing with multivariate records, firstly, a measure of synchronization is chosen, typically Pearson coefficient (Zhou et al,2006), Equation (13), though other measures are also used (Ortega et al, 2008;Ortega et al, 2010) to check the results' reliability, and then a transformation to distances is performed. Then, a favorite clustering algorithm is used in order to create the hierarchical organization, which will uncover the synchronization clusters present in the data.…”

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

“…Data from FOE recordings provide valuable information about mesial temporal lobe activity 17,29,35 , especially during lateralization to the epileptogenic side in TLE patients 33 . Compared with invasive techniques, the FOE technique is non-traumatic for the brain and involves relatively simple manipulation, and its recordings are of high quality over long periods of time 11 .…”

“…The technique described here is capable of detecting mesial network imbalance in short interictal recordings lasting at most one or two hours 29 .…”

“…In recent works 17,29 it was shown that, using the very same procedure as the one described here, an imbalance in the mesial connectivity in refractory TLE patients is apparent. Mesial connectivity is reduced in the ipsilateral side both during the interictal 29 and ictal 17,29 stages. This result could not be anticipated by looking solely at the areas where the epileptogenic activity arises.…”