Impaired macrophage and memory T-cell responses to Bacillus Calmette-Guerin nonpolar lipid extract
Alice Sarno,
Avelina Leite,
Carlos Augusto
et al.
Abstract:IntroductionThe attenuation of BCG has led to the loss of not only immunogenic proteins but also lipid antigens.MethodsThus, we compared the macrophage and T-cell responses to nonpolar lipid extracts harvested from BCG and Mycobacterium tuberculosis (Mtb) to better understand the role of BCG lipids in the already known diminished responses of the vaccine strain.ResultsRelative to Mtb, nonpolar lipid extract from BCG presented a reduced capacity to trigger the expression of the genes encoding TNF, IL-1b, IL-6 a… Show more
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