Impaired Lung Function Is Associated with Obesity and Metabolic Syndrome in Adults

Abstract

LIN, WEN-YUAN, CHIEN-AN YAO, HAO-CHIEN WANG, AND KUO-CHIN HUANG. Impaired lung function is associated with obesity and metabolic syndrome in adults. Obesity. 2006;14:1654 -1661. Objective: Impaired lung function is associated with obesity and insulin resistance. In this study, we investigated the relationship between metabolic syndrome and impaired lung function in adults. Research Methods and Procedures:A total of 46,514 subjects 20 years and over (21,669 men and 24,845 women, mean age ϭ 37.3 Ϯ 11.2 and 37.0 Ϯ 11.3 years, respectively) were recruited from four nationwide MJ Health Screening Centers in Taiwan from 1998 to 2000. Metabolic syndrome was defined using the National Cholesterol Education Panel (NCEP) metabolic syndrome criteria or America Heart Association/National Heart Lung Blood Institute (AHA/NHLBI) criteria. The relationship between metabolic syndrome and lung function test was examined using multivariate logistic regression analysis. Results: The prevalence of impaired lung function was 11.1% in men and 14.0% in women. The prevalence of metabolic syndrome was 5.8% using NCEP criteria and 12.8% using AHA/NHLBI criteria. In multivariate logistic regression analysis with adjustment for age, gender, BMI, smoking, alcohol drinking, and physical activity, restrictive lung impairment was independently associated with increased risk of having metabolic syndrome (p Ͻ 0.01, odds ratios ϭ 1.221 using NCEP criteria and 1.150 using AHA/ NHLBI criteria).Discussion: Obesity and metabolic syndrome were associated with impaired lung function in adults in Taiwan. Our results imply that obesity and insulin resistance may be the common pathways underlying lung function impairment and metabolic syndrome. Moreover, lung function test may be applied as an additional evaluation for metabolic syndrome in a clinical setting.

Obesity and hepatitis B infection are associated with increased risk of metabolic syndrome in university freshmen

“…Lifestyle factors such as smoking, physical activities and alcohol consumption are associated with the risk of metabolic syndrome in adults. 1,27,28 Consistently in the present study, we showed that the ORs of having metabolic syndrome significantly decreased with vigorous physical activity and current alcohol consumption ( Table 2). However, smoking was nonsignificantly associated with metabolic syndrome.…”

Metabolic syndrome and lung function in schizophrenia: A pilot study

“…Although our current findings in patients with schizophrenia fit well with the recent documentation in the general population that the prevalence of MetS is associated with restrictive lung impairment (Ford & Mannino, 2004;Lin et al, 2006;Leone et al, 2009;Scarlata et al, 2013), the findings need to be interpreted with caution because of some methodological limitations. First, the current pilot study had a small sample size making it difficult to generalize findings.…”

“…However, currently the mechanisms that underlie the association between impaired lung function and increased cardio-metabolic mortality are largely unknown and they cannot be solely explained by the effects of smoking (Copeland et al, 2007;De Hert et al, 2011;Ozbulut et al, 2013). There is rigorous evidence in the general population that poor lung function is associated with insulin resistance and metabolic diseases (Ford & Mannino, 2004;Lin et al, 2006;Scarlata et al, 2010Scarlata et al, , 2013. This is an important consideration for first-episode and multi-episode patients with schizophrenia, given that they have an increased risk of the metabolic syndrome (MetS) Mitchell et al, 2013a & b).…”

Metabolic Syndrome Biomarkers Predict Lung Function Impairment

“…Previous cross-sectional studies have suggested associations of impaired lung function with insulin resistance, type II diabetes mellitus, and MetSyn (14)(15)(16)(17)(18). The temporal relationship of MetSyn biomarkers and ventilatory function decline is in dispute.…”