Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study

Hole, David; Watt, Graham; Davey-Smith, George; Hart, Carole; Gillis, Charles R.; Hawthorne, Victor M.

doi:10.1136/bmj.313.7059.711

Cited by 795 publications

(635 citation statements)

References 22 publications

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“…Both in the general population (Hole et al, 1996;Sin et al, 2005) and also in patients with schizophrenia, an impaired lung function is associated with higher cardiovascular risk and increased mortality (Himelhoch et al, 2004;Hoang et al, 2011;Martens et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and lung function in schizophrenia: A pilot study

Vancampfort

Probst

Stubbs

et al. 2014

Psychiatry Research

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Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and lung function in schizophrenia: A pilot study

Vancampfort

Probst

Stubbs

et al. 2014

Psychiatry Research

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“…7 Impaired pulmonary function is clinically relevant as it is associated with increased morbidity and mortality rates. [8][9][10] Several factors may contribute to age-dependent decline of lung function.…”

Section: Introductionmentioning

confidence: 99%

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

et al. 2008

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Objective: To evaluate over a 7-year follow-up period the relationships between changes in body composition, fat distribution and pulmonary function in a sample of elderly men and women. Design: Longitudinal clinical study. Subjects: A total of 47 women and 30 men aged 71.6±2.3 and 71.7±2.2 years, respectively, at baseline with body mass index (BMI) values of 24.96 ± 3.28 and 27.04 ± 3.35 kg m À2 were followed for 7 years. Measurements: Body weight, waist circumference, sagittal abdominal diameter (SAD), fat-free mass (FFM) and fat mass as measured by dual energy X-ray absorptiometry (DXA) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) by spirometry were evaluated at baseline and after a 7-year mean follow-up. Results: In women as in men there were no significant changes in weight, SAD and BMI. A significant decrease in height and FFM was observed in both women and men. Height-adjusted FEV1 and FVC decreased significantly in women and men over the 7-year follow-up. Changes in SAD were the most powerful predictors of 7-year follow-up of FEV1 and FVC after taking into account, respectively, baseline FEV1 and FVC. Linear regression analysis, performed by using 7-year follow-up lung function variables as dependent variables and changes in body composition variables as independent variables, showed that 1 cm SAD increase predicted a decrease in FEV1 and FVC of 31 and 46 ml, respectively, and 1 kg FFM decrease predicted a decrease in FVC of 38 ml. After subdividing our study population into four categories of change in FFM and SAD, patients with decreased FFM and increased SAD showed the highest probability of having a worsening in FEV1 and FVC. Conclusion: Increase in abdominal fat and FFM decline are significant predictors of lung function decline in the elderly. Old subjects developing both abdominal fat gain and FFM loss show the highest probability of developing worsening in lung function.

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“…Impaired lung function is a significant predictor of mortality (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd.…”

Section: Introductionmentioning

confidence: 99%

“…However, most of the studies showing this have focused mainly on forced expiratory volume in 1 second (FEV 1 ) (4)(5)(6)(7)(12)(13)(14) and a smaller number of such studies have focused on forced vital capacity (FVC), including FVC %perd. (1,2,8).…”

Section: Introductionmentioning

confidence: 99%

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

Sekine

Gaina

et al. 2007

Environ Health Prev Med

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Objectives: Only a few long-term follow-up studies with a focus on the association between lung function and mortality in the Japanese population have been undertaken. In this study, we examined the associations of lung function, smoking and the results of allergy skin tests with mortality in a longitudinal study of the Japanese population.Methods: Baseline measurements were performed on residents of Fukui, Japan in 1972, and a follow-up survey was conducted in 2002. By employing a nested case-control design, 596 cases (deaths) and 596 age and sex-matched controls (survivals) were selected. Lung function was assessed using forced vital capacity (FVC) expressed as the normal percent predicted (FVC %pred) and the ratio of forced expiratory volume in 1 second (FEV 1 ) to FVC (FEV 1 /FVC). Allergy skin tests were performed with extracts of house dust, candidia and mixed fungal samples (bronchomycosis). The Brinkman index was used to assess smoking intensity. The Cox proportional hazards model was used to evaluate whether lung function was associated with mortality after adjustment for other potential confounding variables.Results: Those categorized into the first-or second-lowest quartile of FVC %pred had a higher mortality [hazard ratios (HRs) and 95% confidence intervals (CIs): 2.01 (1.26−3.19) and 1.84 (1.11− 3.05)], respectively. On top of these, heavy smoking (BI≥400) was associated with a higher mortality [HR and 95%CI: 1.73 (1.18−2.53)]. There were only weak of associations between the results of allergy skin tests and mortality.Conclusions: These results suggest that FVC %pred of lung function and smoking can serve as long-term independent predictors of mortality.

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Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study

Cited by 795 publications

References 22 publications

Metabolic syndrome and lung function in schizophrenia: A pilot study

Metabolic syndrome and lung function in schizophrenia: A pilot study

Body composition and pulmonary function in the elderly: a 7-year longitudinal study

Nested case-control study on associations between lung function, smoking and mortality in Japanese population

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