Impaired long-term depression in schizophrenia: A cathodal tDCS pilot study

Hasan, Alkomiet; Nitsche, Michael A.; Herrmann, Maximiliane; Schneider‐Axmann, Thomas; Marshall, Louise; Gruber, Oliver; Falkai, Peter; Wobrock, Thomas

doi:10.1016/j.brs.2011.08.004

Cited by 100 publications

(69 citation statements)

References 45 publications

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“…Thirty schizophrenia patients and 45 healthy controls (aged 18-40 years) from previous studies (Hasan et al, 2012a;Hasan et al, 2013b;Hasan et al, 2012b) were pooled and included in this study, resulting in a total sample size of 75. The sample recruitment was conducted from 2009 to 2012.…”

Section: Subjectsmentioning

confidence: 99%

“…The complete protocol has been described previously (Hasan et al, 2012b;Hasan et al, 2011). Electromyographic activity (EMG) was recorded by surface electrodes on the right dorsal interosseus muscle in a belly-tendon montage.…”

Section: Tmsmentioning

confidence: 99%

“…Reviewing the available literature for cortical excitability and plasticity in schizophrenia using noninvasive brain stimulation, a clear picture emerges. Reduced cortical inhibition (eg, reduced short-interval intracortical inhibition, for review see (Bunse et al, 2014)) might cause enhanced cortical noise, leading to reduced spike-timing-dependent plasticity (as measured by paired-associative stimulation) (Frantseva et al, 2008) and reduced nonfocal plasticity (as measured by anodal and cathodal tDCS) via enhanced asynchronous baseline cortical activity (Hasan et al, 2012b;Hasan et al, 2011) Our observed effect of enhanced LTD-like plasticity associated with nicotine intake through chronic smoking might reduce cortical noise and thus increase the signal-tonoise ratio in schizophrenia patients. This would be in line with the observation that LTD has an important role in hippocampal-based learning and memory functions (Collingridge et al, 2010), suggesting a direct contribution of LTD to information storage (Kemp and ManahanVaughan, 2007).…”

Section: Functional Implicationsmentioning

confidence: 99%

“…Furthermore, data of a comparative sample receiving sham tDCS were not available to correct for a putative bias related to regression to the mean in the schizophrenia group following stimulation. Second, we did not recruit patients consecutively, but integrated data from three projects (Hasan et al, 2012a;Hasan et al, 2013b;Hasan et al, 2012b) to answer this specific research question. Third, we neither tested anodal tDCS nor different PAS protocols, which would be important to specifically address the functional consequences of chronic smoking with regard to the focusing effect of nicotine.…”

Section: Limitationsmentioning

confidence: 99%

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Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Strube

Bunse

Nitsche

et al. 2014

Neuropsychopharmacol

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Impaired neuroplastic responses following noninvasive brain stimulation have been reported repeatedly in schizophrenia patients. These findings have been associated with deficits in GABAergic, glutamatergic, and cholinergic neurotransmission. Although various neurophysiological studies have indicated a relationship between nicotine and neuroplasticity in healthy individuals, the present study is the first investigation into the impact of nicotine on LTD-like plasticity in patients with schizophrenia. Cortical excitability and cortical plasticity were explored in 30 schizophrenia patients (17 smoker, 13 nonsmoker) and 45 healthy controls (13 smoker, 32 nonsmoker) by using single-pulse transcranial magnetic stimulation (TMS) before and following cathodal transcranial direct current stimulation (tDCS) applied to the left primary motor cortex. Our analysis revealed abolished LTD-like plasticity in nonsmoking schizophrenia patients. However, these plasticity deficits were not present in smoking schizophrenia patients. In healthy controls, significant MEP reductions following cathodal tDCS were observed in nonsmoking individuals, but only trend-level reductions in smokers. In smoking schizophrenia patients, the severity of negative symptoms correlated positively with reduced neuroplasticity, whereas nonsmoking patients displayed the opposite effect. Taken together, the data of our study support the notion of an association between chronic smoking and the restitution of impaired LTD-like plasticity in schizophrenia patients. Although replication and further research are needed to better understand this relationship, our findings indicate that nicotine intake might stabilize the impaired inhibition-facilitation balance in the schizophrenic brain through a complex interaction between cortical plasticity, and GABAergic and cholinergic neurotransmission, and might explain the reduced prevalence of negative symptoms in this population.

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Section: Subjectsmentioning

confidence: 99%

Section: Tmsmentioning

confidence: 99%

Section: Functional Implicationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Strube

Bunse

Nitsche

et al. 2014

Neuropsychopharmacol

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“…Dopamine enhances long-term potentiation (LTP) and long-term depression (LTD) in animals, and LTP-/LTD-like plasticity in humans (Otani et al, 1998;Bailey et al, 2000). Moreover, impaired cognitive functions (Dubois and Pillon, 1996;Grace et al, 1998) and deficient plasticity (Ueki et al, 2006;Hasan et al, 2012), like those in Parkinson's disease and schizophrenia, are caused by dopaminergic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear Dose-Dependent Impact of D1 Receptor Activation on Motor Cortex Plasticity in Humans

et al. 2014

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The neuromodulator dopamine plays an important role in synaptic plasticity. The effects are determined by receptor subtype specificity, concentration level, and the kind of neuroplasticity induced. D1-like receptors have been proposed to be involved in cognitive processes via their impact on plasticity. Cognitive studies in humans and animals revealed a dosage-dependent effect of D1-like receptor activation on task performance. In humans, D1-like receptor activation re-establishes plasticity under D2 receptor block. However, a dosagedependent effect has not been explored so far. To determine the impact of the amount of D1-like receptor activation on neuroplasticity in humans, we combined sulpiride, a selective D2 receptor antagonist, with the dopamine precursor L-DOPA (25, 100, and 200 mg) or applied placebo medication. The impact on plasticity induced by anodal and cathodal transcranial direct current stimulation (tDCS) was compared with the impact on plasticity induced by excitatory and inhibitory paired associative stimulation (PAS) at the primary motor cortex of healthy humans. Stimulation-generated cortical excitability alterations were monitored by transcranial magnetic stimulation-induced motor-evoked potential amplitudes. D1-like receptor activation produced an inverted U-shaped dose-response curve on plasticity induced by both facilitatory tDCS and PAS. For excitability-diminishing tDCS and PAS, aftereffects were abolished or converted trendwise into facilitation. These data extend findings of dose-dependent inverted U-shaped effects of D1 receptor activation on neuroplasticity of the motor cortex.

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Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

Nitsche¹,

Polanía²,

Kuo³

2015

Brain Stimulation

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Impaired long-term depression in schizophrenia: A cathodal tDCS pilot study

Cited by 100 publications

References 45 publications

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Smoking Restores Impaired LTD-Like Plasticity in Schizophrenia: a Transcranial Direct Current Stimulation Study

Nonlinear Dose-Dependent Impact of D1 Receptor Activation on Motor Cortex Plasticity in Humans

Transcranial Direct Current Stimulation: Modulation of Brain Pathways and Potential Clinical Applications

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