Impaired left ventricular systolic and diastolic function in patients with metabolic syndrome as assessed by strain and strain rate imaging

Gong, Hai‐Bin; Tan, H.S.; Fang, Ning-ning; Song, Tao; Li, Shaohua; Zhong, Ming; Zhang, Wei; Zhang, Yun

doi:10.1016/j.diabres.2008.10.018

Cited by 67 publications

(63 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is clear that this method is useful in obesity (7,13,30). Previous studies of obesity LV function to show subclinical abnormalities was used color Doppler strain or 2D speckle tracking strain (7,8,11,13,(18)(19)(20)30). Barbosa et al (7) reported 50 obese children without comorbidities in 2D speckle tracking analysis, a significant reduction in the longitudinal strain association with BMI.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

View full text Add to dashboard Cite

Background: Impaired subclinical ventricular function may contribute to the risk of cardiovascular disease in obesity. Aims: The aim of this study was to determine the influence of obesity on left ventricular (LV) longitudinal myocardial function in normotensive obese children using two-dimensional (2D) speckle tracking echocardiography (STE). Study Design: Case-control study. Methods: Sixty normotensive obese children aged 10-16 years (mean age, 13.9±2.3 years) were compared with 50 normal-weight controls. Obese participants had a body mass index (BMI)≥95 th percentile. Regional strain/strain rate (SR) values were compared with left ventricular (LV) parameters. The correlation was studied by linear regression analysis. Results: Obese subjects exhibited a significantly higher LV end-diastolic diameter, left atrium/aortic diameter ratio, and LV mass/index when compared to controls (p<0.001). Left ventricular ejection fraction and regional systolic myocardial velocities were similar in the obese and control groups. By 2D STE, regional strain of both the septal wall (average strain:

show abstract

Section: Discussionmentioning

confidence: 99%

“…These strain parameters are affected to a much lesser extent by cardiac rotation and passive cardiac motion (2,11,16). Previous studies have demonstrated decreased regional myocardial function related to body mass index (BMI) by strain imaging studies (7,8,11,13,(17)(18)(19)(20).…”

mentioning

confidence: 99%

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Ultrasonography of the carotid arteries and the heart was performed by a trained clinical technician. Intima-media thickness (IMT) and left ventricular mass index (LVMI) were determined as previously described 21,22 . The early (E) and late (atrial - A) ventricular filling velocity ratio (E/A) determined by pulsed Doppler echocardiography, the E-A ratio (E'/A') determined by tissue velocity imaging, and the ratio of E velocity (E/E') determined by pulsed Doppler echocardiography to that by tissue velocity imaging were then calculated.…”

Section: Methodsmentioning

confidence: 99%

ALK7 Gene Polymorphism is Associated with Metabolic Syndrome Risk and Cardiovascular Remodeling

Zhang¹,

Wang²,

Zhang³

et al. 2013

Arquivos Brasileiros De Cardiologia

Self Cite

View full text Add to dashboard Cite

BackgroundActivin receptor-like kinase 7 (ALK7) is a type I receptor for the TGF-β superfamily and has recently been demonstrated to play an important role in the maintenance of metabolic homeostasis. ObjectiveTo investigate the association of the ALK7 gene polymorphism with metabolic syndrome (MetS) and cardiovascular remodeling in MetS patients. MethodsThe single nucleotide polymorphism rs13010956 in the ALK7 gene was genotyped in 351 Chinese subjects undergoing carotid and cardiac ultrasonography. The associations of the ALK7 gene polymorphism with the MetS phenotype, MetS parameters, and cardiovascular ultrasonic features were analyzed. ResultsThe rs13010956 polymorphism in the ALK7 gene was found to be significantly associated with the MetS phenotype in females (p < 0.05) and was also significantly associated with blood pressure in the total (p < 0.05) and female populations (p < 0.01). Further analysis revealed that rs13010956 was associated with mean intima-media thickness of the carotid arteries in females (p < 0.05). After control for body mass index, blood pressure, fasting blood glucose, and triglycerides, rs13010956 was also found to be significantly associated with left ventricular mass index in the total (p < 0.05) and female populations (p < 0.05). ConclusionOur findings suggested that the ALK7 gene polymorphism rs13010956 was significantly associated with MetS risk in females and may be involved in cardiovascular remodeling in MetS patients.

show abstract

“…Strain (deformation) or strain rate (rate of deformation) can be assessed in patients by echocardiography using tissue Doppler or speckle tracking echocardiography (Dandel & Hetzer, 2009) or with tagged MRI , and in experimental studies by sonomicrometry (Urheim et al, 2000). The indices have proven superior to established indices of myocardial function to assess myocardial infarct size (Becker et al, 2006;Chan et al, 2006;Gjesdal et al, 2008;Vartdal et al, 2007), hypertrophic cardiomyopathy (Serri et al, 2006), and in metabolic syndrome (Gong et al, 2009), ads incremental value in predicting outcome in cardiovascular disease , and predicts arrhythmic events after myocardial infarct (Haugaa et al, 2009). Strain and strain rate (SR) were developed as clinical indices of regional myocardial deformation (Edvardsen et al, 2001;Gotte et al, 2001;Mirsky & Parmley, 1973;Rademakers et al, 1994;Zhang et al, 2005) and have been introduced and validated using tagged MRI and sonomicrometry (Derumeaux et al, 2001;Urheim et al, 2000).…”

Section: Fig 1 Mathematical Relation Between Deformation Indicesmentioning

confidence: 99%

Tissue Doppler in Ischemic Heart Disease

Gjesdal¹,

Edvardsen²

2011

Establishing Better Standards of Care in Doppler Echocardiography, Computed Tomography and Nuclear Cardiology

View full text Add to dashboard Cite

Impaired left ventricular systolic and diastolic function in patients with metabolic syndrome as assessed by strain and strain rate imaging

Cited by 67 publications

References 37 publications

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

ALK7 Gene Polymorphism is Associated with Metabolic Syndrome Risk and Cardiovascular Remodeling

Tissue Doppler in Ischemic Heart Disease

Contact Info

Product

Resources

About