Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation
Funsho E. Fakuade,
Dominik Hubricht,
Vanessa Möller
et al.
Abstract:BACKGROUND:
Alterations in the buffering of intracellular Ca
2+
, for which myofilament proteins play a key role, have been shown to promote cardiac arrhythmia. It is interesting that although studies report atrial myofibrillar degradation in patients with persistent atrial fibrillation (persAF), the intracellular Ca
2+
buffering profile in persAF remains obscure. Therefore, we aim to investigate the intracellular buffering of c… Show more
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