Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging

“…The medication washout subgroup analysis included 8 data sets 13,22,24,25,27,30,41,44 that compared 260 patients with MDD and 272 healthy controls. Fractional anisotropy reductions were identified in the white matter of the right cerebellum hemispheric lobule, body of the CC, bilateral SLF III and the long segment of the arcuate network (Table 3 and Appendix 1, Fig.…”

“…Tract-based spatial statistics (TBSS) isolates the central core of white matter tracts with the highest FA and reports significant clusters within that white matter skeleton. 21 Results from whole-brain studies have suggested widespread white matter abnormalities in MDD in regions such as the frontal gyrus, 15,22,23 cerebellum, 22,24,25 right thalamus, 24,25 right parietal lobe, 22,23 corpus callosum (CC) 26,27 and superior longitudinal fasciculus (SLF). [28][29][30] However, these results are not consistent, probably owing to small or heterogeneous study samples and methodological differences.…”

Reconciling Variable Findings of White Matter Integrity in Major Depressive Disorder

“…In an effort to better understand the pathophysiology of MDD and develop more effective treatments, much research has focused on delineating the structure and function of this mood regulation network. Although many studies have focused on the function of the network (Drevets et al, 2008b;Hafeman et al, 2012;Mayberg, 2003a, b;Murray et al, 2011;Phillips, 2006), including functional connectivity between key brain regions (Craddock et al, , 2012Greicius, 2008Greicius, , 2007James et al, 2009;Seminowicz et al, 2004;Sheline et al, 2010), others have focused on the structural connectivity of the network, ie, the white matter (WM) pathways between brain regions (Abe et al, 2010;Blood et al, 2010;Cole et al, 2012;Cullen et al, 2010;Kieseppa et al, 2010;Korgaonkar et al, 2011;Ma et al, 2007;Tha et al, 2013;Wu et al, 2011;Zhu et al, 2011;Zou et al, 2008).…”

“…Numerous DTI studies have looked for WM integrity differences in patients with MDD (Abe et al, 2010;Blood et al, 2010;Cole et al, 2012;Cullen et al, 2010;Kieseppa et al, 2010;Korgaonkar et al, 2011;Ma et al, 2007;Tha et al, 2013;Wu et al, 2011;Zhu et al, 2011;Zou et al, 2008). However, the findings have been highly variable with respect to the location and direction of the difference in FA (Table 1).…”

Characteristics of Diffusional Kurtosis in Chronic Ischemia of Adult Moyamoya Disease: Comparing Diffusional Kurtosis and Diffusion Tensor Imaging

“…Diffusion tensor imaging is useful for determining white matter integrity and providing parameters sensitive to changes in axons, myelin, and organelle structures. 4,5 Indeed, DTI analysis has revealed a widespread decline in white matter integrity in the normal-appearing brain with MMD. 3 Thus, DTI can detect early-stage ischemic injury, which potentially predicts future cognitive outcomes.…”