Impaired instructive and protective barrier functions of the endothelial cell glycocalyx pericellular matrix is impacted in COVID‐19 disease
Margaret M. Smith,
James Melrose
Abstract:The aim of this study was to review the roles of endothelial cells in normal tissue function and to show how COVID‐19 disease impacts on endothelial cell properties that lead to much of its associated symptomatology. This places the endothelial cell as a prominent cell type to target therapeutically in the treatment of this disorder. Advances in glycosaminoglycan analytical techniques and functional glycomics have improved glycosaminoglycan mimetics development, providing agents that can more appropriately tar… Show more
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