Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders

Mosconi, Matthew W.; Kay, Margaret; D'Cruz, Anna Maria; Seidenfeld, A.; Guter, Stephen J.; Stanford, Lisa D.; Sweeney, John A.

doi:10.1017/s0033291708004984

Cited by 191 publications

(197 citation statements)

References 46 publications

(58 reference statements)

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“…Finally, Mosconi et al (2009) presented adults with ASD and ageand IQ-matched TD peers with a Gap-Overlap task in which targets were presented at three different visual angles in the periphery. Participants were instructed to look towards the peripheral target as soon as it appeared, and visual orienting was measured using EOG during Gap and Overlap trials.…”

Section: Studies During Childhood and Adulthoodmentioning

confidence: 99%

Impairments to visual disengagement in autism spectrum disorder: A review of experimental studies from infancy to adulthood

Sacrey

Armstrong

Bryson

et al. 2014

Neuroscience & Biobehavioral Reviews

124

107

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Section: Studies During Childhood and Adulthoodmentioning

confidence: 99%

Impairments to visual disengagement in autism spectrum disorder: A review of experimental studies from infancy to adulthood

Sacrey

Armstrong

Bryson

et al. 2014

Neuroscience & Biobehavioral Reviews

124

107

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“…verbal fluency) in a sample of young people with ASD. Mosconi et al (2009) reported that impaired inhibition of prepotent responses was related to increased severity of higher order Tager non-verbal ability; OCD: obsessive compulsive disorder; PDD-NOS: pervasive developmental disorder-not otherwise specified; PIQ: performance intelligence quotient; PLI: pragmatic language impairment; r: correlation coefficient; R 2 : coefficient of determination; RBS-R: Repetitive Behaviour Scale-Revised; RRBIs: restricted and repetitive behaviours and interests; SCQ: Social Communication Questionnaire; SLI: specific language impairment; SRS: Social Responsiveness Scale; TD: typically developing, ToM: Theory of Mind; VA: verbal ability; VABS: Vineland Adaptive Behaviour Scales; VIQ: verbal intelligence quotient. Cohen's d, Pearson's correlation coefficient r and R 2 are reported to convey effect sizes.…”

Section: Executive Functions and Asd Symptomsmentioning

confidence: 99%

Exploring the ‘fractionation’ of autism at the cognitive level

Brunsdon

Happé

2013

Autism

166

118

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Autism spectrum disorders are defined by difficulties across a range of areas: social and communication difficulties and restricted and repetitive behaviours and interests. It has been suggested that this triad of symptoms cannot be explained by a single cause at the genetic, neural or cognitive level. This article reviews the evidence for a 'fractionable' autism triad at the cognitive level, highlighting questions for future research.

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“…lower-level repetitive behavioural patterns), but not Asperger disorder. For example, repetitive behaviours in autism may result from impaired inhibition, 26 whereas such behaviour in Asperger disorder could result from a failure to 'spontaneously generate novel behaviour without prompting' 27 (p 843) (reflecting higher-level repetitive behaviours, including circumscribed interests), although this hypothesis requires further investigation (see Rinehart et al 5 for a review).…”

Section: P 195)mentioning

confidence: 99%

A preliminary transcranial magnetic stimulation study of cortical inhibition and excitability in high‐functioning autism and Asperger disorder

Enticott

Rinehart

Tonge

et al. 2010

Develop Med Child Neuro

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AIM Controversy surrounds the distinction between high-functioning autism (HFA) and Asperger disorder, but motor abnormalities are associated features of both conditions. This study examined motor cortical inhibition and excitability in HFA and Asperger disorder using transcranial magnetic stimulation (TMS).METHOD Participants were diagnosed by experienced clinicians strictly according to DSM-IV criteria. Participants with HFA (nine males, two females; mean age 16y 8mo, SD 4y 5mo) or Asperger disorder (11 males, three females; mean age 19y 1mo, SD 4y 2mo) and neurotypical participants (eight males, three females; mean age 19y 0mo, SD 3y 1mo) were administered a paired-pulse TMS paradigm intended to assess motor cortical inhibition and excitability. Responses to TMS were recorded by electromyography. RESULTSCortical inhibition was significantly reduced in the HFA group compared with both the Asperger disorder (p<0.001) and neurotypical (p<0.001) groups, suggesting disruption of activity at gamma-aminobutyric acid A (GABA A ) receptors. There was no group difference in cortical excitability.INTERPRETATION Cortical inhibition deficits may underlie motor dysfunction in autism, and perhaps even relate to specific clinical symptoms (e.g. repetitive behaviours). These findings provide novel evidence for a possible neurobiological dissociation between HFA and Asperger disorder based on GABAergic function.Both autism and Asperger disorder involve social, communicative, motor, and behavioural disturbances (including stereotyped and repetitive behaviours), but there is controversy surrounding their clinical distinction, 1 coupled with a relatively limited neurobiological understanding of the disorders. These conditions are primarily differentiated on the basis of language and communication delay, which must be present in autism but, by definition, is absent in Asperger disorder. 2 In addition, although intelligence in individuals with Asperger disorder is typically within the average range, the majority of individuals with autism have intellectual disability. However, clinical research has demonstrated that the psychosocial profile of typical intelligent individuals with autism (i.e. highfunctioning autism [HFA]) is convergent with that of individuals with Asperger disorder. 3 Such findings form the basis of the argument that autism and Asperger disorder are not clinically distinct disorders, but are clinical labels that can be used interchangeably. By contrast, others have argued that the initial significant language delays that characterize autism (but not Asperger disorder) place the two disorders on separate neurodevelopmental trajectories. 4 The hypothesis that autism and Asperger disorder are clinically separate disorders with distinct neurobiological underpinnings has been supported by neuropsychological and neurophysiological research that shows dissociations in visual perception, language, attention, executive function, and motor function. 5 The neural circuitry involved in motor control is reasonably well defined...

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Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders

Abstract: Background-Impairments in executive cognitive control, including a reduced ability to inhibit prepotent responses, have been reported in autism spectrum disorders (ASD). These deficits may underlie patterns of repetitive behaviors associated with the disorder.

Cited by 191 publications

References 46 publications

Impairments to visual disengagement in autism spectrum disorder: A review of experimental studies from infancy to adulthood

Impairments to visual disengagement in autism spectrum disorder: A review of experimental studies from infancy to adulthood

Exploring the ‘fractionation’ of autism at the cognitive level

A preliminary transcranial magnetic stimulation study of cortical inhibition and excitability in high‐functioning autism and Asperger disorder

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