Impaired inhibition of prepotent motor actions in patients with Tourette syndrome

Wylie, Scott A.; Claassen, Daniel O.; Kanoff, Kristen; Ridderinkhof, K.R.; Wildenberg, Wery P. M. van den

doi:10.1503/jpn.120138

Cited by 43 publications

(37 citation statements)

References 42 publications

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“…Changes in reinforcement learning and in action control (e.g., inhibitory motor control) are reported in many of the most common psychiatric and neurologic basal ganglia disorders, including Obsessive-Compulsive Disorder (Gillan et al, 2011; Marsh et al, 2015), Tourette's Syndrome (Worbe et al, 2011; Wylie et al, 2013), Parkinson's Disease (Wylie et al, 2009ab; Frank, 2005), and Huntington's Disease (Lawrence et al, 1999; Holl et al, 2013), but have been studied in isolation. A first question will be to determine if different forms of basal ganglia dysfunction alter the action-valence learning biases in dissociable ways.…”

Section: Discussionmentioning

confidence: 99%

“…A central component of cognitive control in times of conflict is the inhibition of conflicting response alternatives, which has been linked to frontal projections to basal ganglia that engage the indirect and hyperdirect basal ganglia pathways to brake actions selectively (Aron et al, 2007; Jahfari et al, 2011; Mink, and Thach, 1993). Disorders associated with basal ganglia dysfunction produce pronounced deficits in conflict resolution and inhibitory control, and pharmacological (e.g., dopamine) and deep brain stimulation manipulations of basal ganglia function modulate these processes directly (Gillan et al, 2011; Holl et al, 2013; Worbe et al, 2011; Wylie et al, 2009a, 2009b, 2010, 2012, 2013). …”

Section: Introductionmentioning

confidence: 99%

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Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Wouwe

Wildenberg

Ridderinkhof

et al. 2015

Brain and Cognition

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The inhibition of impulsive response tendencies that conflict with goal-directed action is a key component of executive control. An emerging literature reveals that the proficiency of inhibitory control is modulated by expected or unexpected opportunities to earn reward or avoid punishment. However, less is known about how inhibitory control is impacted by the processing of task-irrelevant stimulus information that has been associated previously with particular outcomes (reward or punishment) or response tendencies (action or inaction). We hypothesized that stimulus features associated with particular action-valence tendencies, even though task irrelevant, would modulate inhibitory control processes. Participants first learned associations between stimulus features (color), actions, and outcomes using an action-valence learning task that orthogonalizes action (action, inaction) and valence (reward, punishment). Next, these stimulus features were embedded in a Simon task as a task-irrelevant stimulus attribute. We analyzed the effects of action-valence associations on the Simon task by means of distributional analysis to reveal the temporal dynamics. Learning patterns replicated previously reported biases; inherent, Pavlovian-like mappings (action-reward, inaction-punishment avoidance) were easier to learn than mappings conflicting with these biases (action-punishment avoidance, inaction-reward). More importantly, results from two experiments demonstrated that the easier to learn, Pavlovian-like action-valence associations interfered with the proficiency of inhibiting impulsive actions in the Simon task. Processing conflicting associations led to more proficient inhibitory control of impulsive actions, similar to Simon trials without any association. Fast impulsive errors were reduced for trials associated with punishment in comparison to reward trials or trials without any valence association. These findings provide insight into the temporal dynamics of task irrelevant information associated with action and valence modulating cognitive control. We discuss putative mechanisms that might explain these interactions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Wouwe

Wildenberg

Ridderinkhof

et al. 2015

Brain and Cognition

View full text Add to dashboard Cite

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“…These forms of cognitive control are separable experimentally and have been linked to frontal-basal ganglia circuitries (Aron et al, 2007; Forstmann et al, 2008a, b, c; Jahfari et al, 2011; Gillan et al, 2011; Holl et al, 2013; van den Wildenberg et al, 2010; Worbe et al, 2011). Studies show their compromise in Parkinson’s disease and their modulation by dopamine pharmacotherapy (Wylie et al, 2009a, b, 2010a, b, 2012a, b, 2013). These control mechanisms are crucial for navigating dynamic, action-oriented environments that may trigger conflicting, undesired, or impulsive response tendencies.…”

Section: Introductionmentioning

confidence: 99%

Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses

et al. 2017

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Frontal-basal ganglia circuitry dysfunction caused by Parkinson’s disease impairs important executive cognitive processes, such as the ability to inhibit impulsive action tendencies. Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s disease improves the reactive inhibition of impulsive actions that interfere with goal-directed behavior. An unresolved question is whether this effect depends on stimulation of a particular Subthalamic Nucleus subregion. The current study aimed to 1) replicate previous findings and additionally investigate the effect of chronic versus acute Subthalamic Nucleus stimulation on inhibitory control in Parkinson’s disease patients off dopaminergic medication 2) test whether stimulating Subthalamic Nucleus subregions differentially modulate proactive response control and the proficiency of reactive inhibitory control. In the first experiment, twelve Parkinson’s disease patients completed three sessions of the Simon task, Off Deep brain stimulation and medication, on acute Deep Brain Stimulation and on chronic Deep Brain Stimulation. Experiment 2 consisted of 11 Parkinson’s disease patients with Subthalamic Nucleus Deep Brain Stimulation (off medication) who completed two testing sessions involving of a Simon task either with stimulation of the dorsal or the ventral contact in the Subthalamic Nucleus. Our findings show that Deep Brain Stimulation improves reactive inhibitory control, regardless of medication and regardless of whether it concerns chronic or acute Subthalamic Nucleus stimulation. More importantly, selective stimulation of dorsal and ventral subregions of the Subthalamic Nucleus indicates that especially the dorsal Subthalamic Nucleus circuitries are crucial for modulating the reactive inhibitory control of motor actions.

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“…Previous studies have attempted to address TS as a generalized failure of action inhibition, but that conceptualization may cast the net too wide 7– 9 . A 2013 publication from Wylie et al 10 had suggested some deficit in response inhibition (action stopping) in TS. In 2016, the group reported a new study in young adults with TS, now better controlled for comorbidity 11 .…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2016

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Impaired inhibition of prepotent motor actions in patients with Tourette syndrome

Cited by 43 publications

References 42 publications

Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Easy to learn, hard to suppress: The impact of learned stimulus–outcome associations on subsequent action control

Focused stimulation of dorsal subthalamic nucleus improves reactive inhibitory control of action impulses

Tourette syndrome research highlights from 2016

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