Impaired Hemorheology in Exacerbations of COPD

Abstract

Background Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. Materials and Methods The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to Global Initiative for Chronic Obstructive Lung Disease guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer. Results RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control. Conclusion Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial.

Estabilidade de Membrana de Eritrócitos em Pacientes Portadores de Doença Pulmonar Obstrutiva Crônica em Oxigenioterapia Domiciliar Prolongada

“…Less deformable erythrocytes generally have irregular shapes and do not return to their original shape easily, creating erythrocyte populations of different sizes and conformations. Indeed, some studies have shown lower erythrocyte deformability in COPD (Santini et al, 1997;Coppola et al, 1999;Ugurlu et al, 2017). As in animal model, a continuous reduction in deformability was associated with the progression of an inflammatory response (Silva-Herdade et al, 2016), the lower deformability of erythrocytes described in COPD may be due to the inflammatory condition of the disease, demonstrated in this study by means of increased leukocyte count and CRP values.…”

“…In fact, this is consistent with the decrease in total and indirect bilirubin levels, which indicate a decrease in erythrocyte clearance (Memon et al, 2016), and with the lower levels of iron, which means the existence of a restrictive condition to erythropoiesis . Certainly, this predominance of more mature erythrocytes, which have less deformability, impairs the adequate supply of oxygen to the tissues, worsening the clinical condition of the patient with COPD, mainly in exacerbations of the disease (Ugurlu et al, 2017).…”

A survey of an eight-breed cross swine heterogeneous population demonstrates the associations among immune cell traits, lung lesions and Mycoplasma abundances

“…The decreased levels of MCHC could be linked to the deformation of red blood cells as indicated by the evaluated RDW-CV. A recent study in humans showed that MCHC levels were lower in a control (healthy) group than in a newly diagnosed COPD group (28). The process of hypoxia, induced by lower MCHC, may contribute to the lung tumor cell metastasis and poor prognosis (29).…”

Ani İşitme Kaybı (AİK) Hastalarının Hemoreolojik Parametrelerinin İncelenmesi

“…Birçok klinik çalışmada, kan akışkanlığı ile kan dolaşımını da içeren çeşitli hastalıkların şiddeti arasındaki ilişki doğrulanmıştır. Çeşitli patolojik koşullarda, azalmış eritrosit deformabilitesi ve artmış eritrosit agregasyonu gibi akış davranışındaki değişikliklerin yanı sıra, plazma ve kan viskozitesinde de artışlar gösterilmiştir (8)(9)(10)(11). Bazı çalışmalar hemoreolojik değişikliklerin koklear vasküler tıkanıklık ile ilişkili olabileceğini rapor etmiştir (2, 12, 13).…”