Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study.

Wagenknecht, Lynne E.; D'Agostino, R B; Haffner, S M; Savage, Peter J.; Rewers, Marian

doi:10.2337/diacare.21.11.1812

Cited by 145 publications

(118 citation statements)

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“…Our data also demonstrated that circulating omentin levels correlated inversely with creatinine levels, and positively with eGFR. Because glucose intolerance and renal dysfunction are shown to strongly associate with increased IMT, 15,16 it is reasonable that these disease conditions could affect circulating omentin levels. However, the present study suggests that omentin levels are predictive of carotid IMT, independent of glucose levels and renal function.…”

Section: Discussionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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Obesity is causally linked with the development of atherosclerosis. Omentin is an adipocytokine whose concentrations are reduced in obese individuals. Here we examined the relationship between plasma omentin levels and carotid intima-media thickness (IMT), a marker of early atherosclerosis, in apparently healthy Japanese men. Participants were 100 Japanese men who underwent a medical checkup. Maximal IMT (max-IMT) and mean-IMT in common carotid artery were measured by highresolution carotid ultrasound system. Plasma omentin concentrations were determined by enzyme-linked immunosorbent assay. Circulating omentin levels correlated negatively with body mass index, waist circumference, fasting glucose, creatinine, max-IMT and mean-IMT, and positively with estimated glomerular filtration rates (eGFR). Single regression analysis demonstrated that max-IMT associated with age, eGFR and omentin levels, and that mean-IMT associated with age, fasting glucose, eGFR and omentin levels. Multiple regression analysis revealed that omentin levels, together with age, correlated with max-IMT and mean-IMT. Our data document that circulating omentin levels independently and negatively associate with carotid IMT in this population, suggesting that measurement of omentin may be useful for assessment of carotid IMT.

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Section: Discussionmentioning

confidence: 99%

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

et al. 2011

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“…20 This fi nding contrasts with the Insulin Resistance Atherosclerosis Study, which included whites, African Americans, and Latinos and reported no difference in IMT values between those with normal and impaired glucose tolerance. 25 An explanation for this ethnic difference could be the degree of insulin resistance in the South Asians versus the other ethnic groups that may lead to greater endothelial dysfunction 26 and earlier subclinical atherosclerosis. 27,28 This fi nding supports the "ticking clock" hypothesis 29 that cardiovascular disease may begin before the onset of clinical diabetes in Indians.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Correlates of Diabetes in South Asian Indians in the United States: Findings From the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Study and the Multi-Ethnic Study of Atherosclerosis

Kanaya

Wassel

Mathur

et al. 2010

Metabolic Syndrome and Related Disorders

125

105

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Background: Individuals from South Asia have high diabetes prevalence despite low body weight. We compared the prevalence of diabetes among South Asian Indians with other U.S. ethnic groups and explored correlates of diabetes. Methods: This was a cross-sectional study of 150 South Asian Indians (ages 45-79) in California, using similar methods to the Multi-Ethnic Study of Atherosclerosis (MESA). Type 2 diabetes was classifi ed by fasting plasma glucose (FPG) ≥126 mg/dL, 2-h postchallenge glucose ≥200 mg/dL, or use of hypoglycemic medication. Results: A total of 29% of Asian Indians had diabetes, 37% had prediabetes, and 34% had normal glucose tolerance. After full adjustment for covariates, Indians still had signifi cantly higher odds of diabetes compared to whites and Latinos, but not signifi cantly different from African Americans and Chinese Americans in MESA: Indians [odds ratio (OR), 1.0], whites [OR, 0.29; 95% confi dence interval (CI), 0.17-0.49], Latinos (OR, 0.59; CI, 0.34-1.00) African Americans (OR, 0.77; CI 0.45-1.32), Chinese Americans (OR, 0.78, CI, 0.45-1.32). Variables associated with prediabetes or diabetes among Indians included hypertension, fatty liver, visceral adiposity, microalbuminuria, carotid intima media thickness, and stronger traditional Indian beliefs. Conclusions: Indian immigrants may be more likely to have diabetes than other U.S. ethnic groups, and cultural factors may play a role, suggesting that this is a promising area of research.

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“…This might explain why IMT in our study and in other studies was a weaker correlate of diabetes. For instance in a recent paper from the investigators of the Insulin Resistance Atherosclerosis Study, only subjects with established Type II diabetes but not those with IGT or newly diagnosed Type II diabetes showed a marginally increased IMT after adjustment for confounding factors [63].…”

Section: Discussionmentioning

confidence: 99%

Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study

et al. 2000

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Atherosclerotic vascular diseases such as myocardial infarction, stroke and lower extremity arteriopathy are well-known severe complications of impaired glucose tolerance (IGT) and Type II (non-insulin-dependent) diabetes mellitus [1±7] and account for up to 60±70 % of deaths in diabetic subjects [8]. Impaired glucose tolerance and Type II diabetic patients often have, however, multiple metabolic, haemodynamic and haemocoagulative defects such as high triglycerides and low HDL cholesterol, high blood pressure and high fibrinogen [9±15], which are cardiovascular risk factors in themselves [16]. These defects can precede the development of glucose intolerance by several years [17, 18]. Thus, the independent contribution of glucose intolerance and its bio- Diabetologia (2000) Abstracts Aims/hypothesis. Cardiovascular disease is a wellknown severe complication of impaired glucose tolerance and Type II (non-insulin-dependent) diabetes mellitus. The independent contribution of glucose intolerance to cardiovascular disease and the underlying pathogenic mechanisms are still, however, not clear. Methods. In this prospective population-based study, 826 subjects aged 40±79 years underwent high resolution duplex ultrasound examinations of carotid arteries and extensive clinical and laboratory screenings for potential vascular risk factors at baseline and 5 years later. The ultrasound protocol involved measurements of maximum axial diameter of atherosclerotic plaques, if any, in common and internal carotid arteries on both sides and enable differentiation of two main stages in carotid artery disease, termed early non-stenotic and advanced stenotic atherosclerosis. Intima-media thickness was assessed at the follow-up examination. Results. Type II diabetes and, to a lesser extent, impaired glucose tolerance were found to be statistically significant risk predictors of 5-year changes in carotid atherosclerosis. These associations were in part independent of other vascular risk factors typically clustering with glucose intolerance. Both impaired glucose tolerance and Type II diabetes mellitus were not independently related to early non-stenotic atherosclerosis. In contrast, Type II diabetes mellitus was the strongest single risk predictor of advanced stenotic atherosclerosis [odds ratio 5.0 (95 % confidence intervals 2.3±11.1)] and impaired glucose tolerance was of relevance as well [odds ratio 2.8 (1.2±6.4)] (p < 0.001). Conclusion/interpretation. Impaired glucose tolerance and, to a greater extent, Type II diabetes were strong independent predictors of advanced carotid atherosclerosis in our prospective population-based study. [Diabetologia (2000) 43: 156±164]

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Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study.

Abstract: We observed considerably greater IMT among persons with established diabetes but no significant increase in persons with IGT. These data suggest that the increased risk of CHD observed in persons with diabetes may largely develop after the onset of overt diabetes.

Cited by 145 publications

References 0 publications

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men

Prevalence and Correlates of Diabetes in South Asian Indians in the United States: Findings From the Metabolic Syndrome and Atherosclerosis in South Asians Living in America Study and the Multi-Ethnic Study of Atherosclerosis

Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study

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