Impaired glucose tolerance, but not impaired fasting glucose, is a risk factor for early‐stage atherosclerosis

Ando, Tetsu; Okada, Sho; Niijima, Yawara; Hashimoto, Kazuhito; Shimizu, Hiroyuki; Tsuchiya, Takafumi; Yamada, Masanobu; Ohshima, Kihachi; Mori, Masataka; Ono, Kumeo

doi:10.1111/j.1464-5491.2010.03144.x

Cited by 30 publications

(28 citation statements)

References 21 publications

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“…17) Previous studies suggest that increased fasting plasma glucose (FPG), which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM), is a risk factor for arterial stiffness. [18][19][20] Homocysteine (Hcy), a sulphur-containing amino acid produced by the catabolism of dietary methionine, is a known risk factor for the cardiovascular system. 21) Zhou 22) and Gu 23) proved that Hcy levels in type II diabetes patients were associated with the development and progression of macrovasculopathy and eyeground vascular disease, and the mechanism may be related to insulin deficiency and (or) resistance which can influence blood pressure, lipid metabolism, and also affect the metabolism of Hcy.…”

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confidence: 99%

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

Liu

Sun

Yu³

et al. 2016

Int. Heart J.

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SummaryThis study aimed to investigate the independent and joint association of blood pressure (BP), homocysteine (Hcy), and fasting blood glucose (FBG) levels with brachial-ankle pulse wave velocity (baPWV, a measure of arterial stiffness) in Chinese hypertensive adults.The analyses included 3967 participants whose BP, Hcy, FBG, and baPWV were measured along with other covariates. Systolic BP (SBP) was analyzed as 3 categories (SBP < 160 mmHg; 160 to 179 mmHg; ≥ 180 mmHg); Hcy as 3 categories (< 10 μmol/L; 10 to 14.9 μmol/L; ≥ 15.0 μmol/L) and FBG: normal (FBG < 5.6 mmol/L), impaired (5.6 mmol/L ≤ FBG < 7.0 mmol/L), and diabetes mellitus (FBG ≥ 7.0 mmol/L). We performed linear regression analyses to evaluate their associations with baPWV with adjustment for covariables.When analyzed individually, BP, Hcy, and FBG were each associated with baPWV. When BP and FBG were analyzed jointly, the highest baPWV value (mean ± SD: 2227 ± 466 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and SBP ≥ 180 mmHg (β = 432.5, P < 0.001), and the lowest baPWV value (mean ± SD: 1692 ± 289 cm/s) was seen in participants with NFG and SBP < 160 mmHg. When Hcy and FBG were analyzed jointly, the highest baPWV value (2072 ± 480 cm/s) was observed in participants with FBG ≥ 7.0 mmol/L and Hcy ≥ 15.0 μmol/L (β = 167.6, P < 0.001), while the lowest baPWV value (mean ± SD: 1773 ± 334 cm/s) was observed in participants with NFG and Hcy < 10 μmol/L.In Chinese hypertensive adults, SBP, Hcy, and FBG are individually and jointly associated with baPWV. Our findings underscore the importance of identifying individuals with multiple risk factors of baPWV including high SBP, FBG, and Hcy. (Int Heart J 2016; 57: 627-633) Key words: Hypertension, Arterial stiffness, Diabetes, MTHFR T here is a growing recognition of the potential important role of pulse wave velocity (PWV), a marker of arterial stiffness, in relation to cardiovascular risk, including isolated systolic hypertension (ISH) 1) and blood pressure (BP) progression.2-4) A recent study showed that baPWV was an independent determinant of an individual response to antihypertensive treatment.5) In addition, recent longitudinal studies have demonstrated that increased baPWV levels predict cardiovascular mortality and morbidity among high-risk patients and the general population. [6][7][8][9] Like blood pressure, arterial stiffness can be easily and noninvasively assessed by measuring the pulse wave velocity (PWV).10) The measurement of brachial-ankle PWV (baPWV) is an index of central arterial stiffness with a good correlation with the aortic PWV, 11,12) and is suitable for screening large populations in clinical and community settings.From the

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confidence: 99%

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

Liu

Sun

Yu³

et al. 2016

Int. Heart J.

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“…However, in addition to identifying a novel relationship between postchallenge hyperglycemia and cAIx and PPA, another novel aspect of our study is that we could demonstrate this in relatively young individuals (mean age 38), whereas the above studies examined individuals older than 50 years. As another limitation, but similar to the aforementioned studies on glycemia and PWV [17,18], we have measured all our parameters only once in each individual, and perhaps even closer correlations would have been found with repeat measurements and averaging of those measurements. Finally, there is evidence from prospective studies that 2-h glucose levels predict mortality better than impaired fasting glucose [5].…”

Section: Discussionmentioning

confidence: 87%

“…In addition to these crosssectional data, the progression of IMT over time is predicted closely by postchallenge glucose levels [16]. Furthermore, other studies demonstrated that the 2-h value of the OGTT is the most powerful metabolic predictor of arterial stiffness as determined by pulse wave velocity (PWV) measurements [17,18].…”

Section: Discussionmentioning

confidence: 98%

Postchallenge hyperglycemia is closely related with early vascular damage in overweight and obese patients

Schneider

Ott

Ritt

et al. 2012

Journal of Hypertension

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The 2-h value of the OGTT was superior to fasting glucose levels and HbA1c in predicting cAIx and PPA in young individuals at high risk of type 2 diabetes. Cardiovascular mortality is largely determined by macrovascular complications in type 2 diabetes, and these data suggest that diabetes screening by OGTT may help to identify those individuals with the greatest risk of future vascular complications.

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“…Plasma was separated from whole blood within 1 h after collection, and plasma glucose and HbA1c concentrations were determined as previously reported [7,8]. Brachial-ankle pulse wave velocity (baPWV) was also measured as previously reported 7,8 in order to compare our results and previous results from the point of research objectivity and suitability.…”

Section: Methodsmentioning

confidence: 99%

Subcutaneous abdominal adipose tissue is associated with an index of insulin sensitivity/resistance

et al. 2016

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To assess whether there is any clinical significance for determining the normal range of subcutaneous abdominal fat area, we compared fat area with insulin sensitivity. Visceral and subcutaneous abdominal fat area the L4-L5 thoracic level was determined by computed tomography (CT). Plasma glucose and insulin levels were determined after an overnight fast and calculated by the homeostatic model assessment of insulin resistance (HOMA-IR). We analyzed 350 (180 male and 170 female) subjects whose BMI was 18.5BMI<25. The subcutaneous abdominal fat area of the female subjects was 124.7 § 46.13 cm 2 and that of male subjects was 77.53 § 37.53 cm 2

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Impaired glucose tolerance, but not impaired fasting glucose, is a risk factor for early‐stage atherosclerosis

Cited by 30 publications

References 21 publications

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

The Independent and Joint Association of Blood Pressure, Serum Total Homocysteine, and Fasting Serum Glucose Levels With Brachial-Ankle Pulse Wave Velocity in Chinese Hypertensive Adults

Postchallenge hyperglycemia is closely related with early vascular damage in overweight and obese patients

Subcutaneous abdominal adipose tissue is associated with an index of insulin sensitivity/resistance

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