Impaired Gastric Acid and Pancreatic Enzyme Secretion in Patients With Crohn’s Disease May be a Consequenece of a Poor Nutritional State

Abstract

Malnutrition may play a significant role in the impairment of gastric acid and pancreatic secretion in Crohn's disease patients.

The aetiology and impact of malnutrition in paediatric inflammatory bowel disease

“…It was found that GI energy excretion was higher in an underweight group with CD than in a normal weight group, despite no differences between the two groups for dietary energy intake or resting metabolic rate. Similarly, in another study, malabsorption and increased faecal fat were observed in severely undernourished patients, which was attributed to the impaired gastric acid and pancreatic enzyme secretion in patients with CD (Winter et al, 2004). Interestingly, gastric acid and pancreatic enzyme secretion were severely impaired in 80% of these patients (Winter et al, 2004).…”

“…, 2004). Interestingly, gastric acid and pancreatic enzyme secretion were severely impaired in 80% of these patients (Winter et al. , 2004).…”

The effects of undernutrition and refeeding on metabolism and digestive function

“…Amino acid (L-[1-14 C]leucine) isotope incorporation studies were performed to study pancreatic enzyme protein kinetics in undernourished patients with Crohn's disease[75]. Results revealed impairment of synthesis of the enzymes amylase and trypsin, with marked decrease in zymogen pool size (amylase 1516 AE 874.9 versus 6838 AE 1039 U, P < 0.01; trypsin 417.0 AE 178.3 versus 932.4 AE 142.3 U, P < 0.05), suggesting pancreatic atrophy.…”

Salmonella typhimurium Osteomyelitis des Femurs bei einem Patienten mit Morbus Crohn

“…First is malnutrition with incidence of 25-80% [12]. Malnutrition may diminish gastric acid secretion [13], which represents a barrier for infection [14]. Another barrier for Salmonella infection is normal intestinal fl ora [14], which was probably disrupted in our patient because of long-lasting CD.…”