Impaired gastric accommodation and its role in dyspepsia

Kindt, Sébastien; Tack, Jan

doi:10.1136/gut.2005.085365

Cited by 193 publications

(222 citation statements)

References 92 publications

(101 reference statements)

Supporting

Mentioning

211

Contrasting

Unclassified

Order By: Relevance

“…29 Accelerated gastric emptying in the early postprandial period may be associated with impaired accommodation. 39,40 In addition, in a scintigraphic study, early redistribution of the meal to the distal stomach or accelerated gastric emptying in the postprandial period, suggestive of impaired accommodation, was associated with symptoms of early satiety. 40 Gilja et al 41 have also reported that impaired accommodation was associated with meal-induced symptoms such as PDS-like symptoms.…”

Section: Discussionmentioning

confidence: 99%

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan

Yanagawa

Futagami

Shimpuku

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/Aims There are no available data about the relationship between ghrelin gene genotypes and early phase of gastric emptying in functional dyspepsia (FD) as defined by Rome III classification. Methods We enrolled 74 patients presenting with typical symptoms of FD and 64 healthy volunteers. Gastric motility was evaluated using the 13 C-acetate breath test. We used Rome III criteria to evaluate upper abdominal symptoms and self-rating questionnaires for depression (SRQ-D) scores to determine status of depression. The Arg51Gln (346G>A), preproghrelin (3056T>C), Leu72Met (408C>A), Gln90Leu (3412T>A) and G-protein β3 (825C>T) polymorphisms were analyzed in the DNA from blood samples of enrolled subjects. Genotyping was performed by polymerase chain reaction. Results There was a significant relationship between the Gln90Leu3412 genotype and SRQ-D score in FD patients ( P = 0.009). Area under the curve at 15 minutes (AUC 15 ) value was significantly associated with the Leu72Met408 genotype ( P = 0.015) but not with entire gastric emptying. Conclusions The Leu72Met (408C>A) single nucleotide polymorphism was significantly associated with early phase of gastric emptying in FD patients. Further studies will be necessary to clarify the association between ghrelin gene single nucleotide polymorphisms and early phase of gastric emptying in FD patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Leu72Met408 Polymorphism of the Ghrelin Gene Is Associated With Early Phase of Gastric Emptying in the Patients With Functional Dyspepsia in Japan

Yanagawa

Futagami

Shimpuku

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

show abstract

“…Increased perception of intestinal stimuli Sensory dysfunction: As previously reported, patients with dyspepsia perceived and tolerated smaller meal volumes than healthy subjects [97,98] . Perception of intragastric content depends on stimulation of tension receptors in the gastric wall [99] .…”

Section: Impaired Abdominal Emptingmentioning

confidence: 52%

Bloating and functional gastro-intestinal disorders: Where are we and where are we going?

Iovino

Bucci

Tremolaterra

et al. 2014

WJG

View full text Add to dashboard Cite

Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients. This symptom has been described with various definitions, such as sensation of a distended abdomen or an abdominal tension or even excessive gas in the abdomen, although bloating should probably be defined as the feeling (e.g. a subjective sensation) of increased pressure within the abdomen. It is usually associated with functional gastrointestinal disorders, like irritable bowel syndrome, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome Ⅲ criteria named functional bloating. In terms of diagnosis, major difficulties are due to the lack of measurable parameters to assess and grade this symptom. In addition, it is still unclear to what extent the individual patient complaint of subjective bloating correlates with the objective evidence of abdominal distension. In fact, despite its clinical, social and economic relevance, bloating lacks a clear pathophysiology explanation, and an effective management endorsement, turning this common symptom into a true challenge for both patients and clinicians. Different theories on bloating etiology call into questions an increased luminal contents (gas, stools, liquid or fat) and/or an impaired abdominal empting and/or an altered intra-abdominal volume displacement (abdomino-phrenic theory) and/ or an increased perception of intestinal stimuli with a subsequent use of empirical treatments (diet modifications, antibiotics and/or probiotics, prokinetic drugs, antispasmodics, gas reducing agents and tricyclic antidepressants). In this review, our aim was to review the latest knowledge on bloating physiopathology and therapeutic options trying to shed lights on those processes where a clinician could intervene to modify disease course. Key words: Bloating; Functional gastro-intestinal disorders; Irritable bowel syndrome; Constipation; Diarrhea Core tip: Bloating is one of the most common and bothersome symptoms complained by a large proportion of patients, mostly with functional gastrointestinal disorders, but when bloating is not part of another functional bowel or gastrointestinal disorder it is included as an independent entity in Rome Ⅲ criteria named functional bloating. Despite its clinical, social and economic Iovino P et al . Bloating and functional gastro-intestinal disorders relevance, bloating lacks a clear pathophysiology explanation and an effective management endorsement. Moreover, it is unclear to what extent subjective complaint of bloating correlates with the objective evidence of abdominal distension. The aim of this paper is to review the latest knowledge on bloating and to explore future research directions to improve its management.

show abstract

“…Children with a history of fundoplication were excluded, because of the change in stomach position and anatomy. Fundoplication can result in decreased gastric accommodation, which may be associated with postprandial fullness and dyspeptic symptoms, 9 which could bias the control group. Children with a history of or an indication for gastrostomy were also excluded.…”

Section: Populationmentioning

confidence: 99%

“…1,3 Delayed gastric emptying, altered antroduodenal motility, and impaired gastric accommodation have been proposed to explain symptoms of functional dyspepsia. [5][6][7][8][9] It is not known if gastroptosis itself leads to certain symptoms or if gastroptosis and related symptoms are the result of another disease. Symptoms related to gastroptosis are nonspecific and could be caused by many other conditions.…”

Section: Introductionmentioning

confidence: 99%