Impaired functioning in euthymic patients with bipolar disorder — HSV-1 as a predictor

Gerber, Sonja; Krienke, Ute J.; Biedermann, N. C.; Grunze, Heinz; Yolken, Robert H.; Dittmann, Sandra; Langosch, Jens M.

doi:10.1016/j.pnpbp.2011.09.003

Cited by 25 publications

(14 citation statements)

References 43 publications

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“…Similar to our result, two studies found that another herpesvirus, HSV (Herpes Simplex Virus), is related to cognitive (executive) deficits and gray matter decreases in patients with schizophrenia but not in controls (Prasad et al, 2010;Prasad et al, 2012b;Schretlen et al, 2010). HSV-1 is also associated with cognitive deficits in patients with BD but not (or at a far lesser extent) in HC (Aiello et al, 2006;Dickerson et al, 2004;Dickerson et al, 2006b;Gerber et al, 2012). Therefore, some authors have proposed that patients with schizophrenia and patients with BD displayean increased brain susceptibility/liability to exogenous assaults (Schretlen et al, 2010).…”

Section: Discussionsupporting

confidence: 90%

Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder

Houenou

d’Albis

Daban

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Discussionsupporting

confidence: 90%

Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder

Houenou

d’Albis

Daban

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Our findings could mean that the association between antibodies and cognitive functioning is not a state effect, but that the presence of antibodies has longer-lasting effects on cognitive functioning. We used different tasks to test the cognitive domains that were found to be associated with HSV1 in previous studies [5], [7]. The fact that we found an association in the same cognitive domain as in previous research with a different task makes the finding more robust.…”

Section: Discussionmentioning

confidence: 48%

“…A recent review summarized several studies that found that HSV1 antibodies were associated with impaired immediate memory and executive functioning in patients with schizophrenia [5]. This association was also found in patients with bipolar disorder [6], [7]. Antibodies to cytomegalovirus (CMV) were found to be associated with impaired visual search and memory function in patients with schizophrenia [8].…”

Section: Introductionmentioning

confidence: 99%

Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study

et al. 2014

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BackgroundInfections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population.MethodsThis study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use.ResultsPresence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning.ConclusionsBoth presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.

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“…Other pathogens previously associated with BPD include influenza type-A, where prenatal exposure leads to a fourfold increase in the risk of developing BPD ( Parboosing et al, 2013 ). Serological detection of HSV-1 antibodies in BPD has been associated with more severe cognitive impairments in BPD patients ( Gerber et al, 2012 ). A study assessing CSF samples for antibodies for neurotropic agents found an increase in antibody production in BPD, but no specific pathogen was common amongst the cases; antibodies to HHV-6A/B were not measured ( Stich et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

et al. 2018

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Early-life infections and associated neuroinflammation is incriminated in the pathogenesis of various mood disorders. Infection with human roseoloviruses, HHV-6A and HHV-6B, allows viral latency in the central nervous system and other tissues, which can later be activated causing cognitive and behavioral disturbances. Hence, this study was designed to evaluate possible association of HHV-6A and HHV-6B activation with three different groups of psychiatric patients. DNA qPCR, immunofluorescence and FISH studies were carried out in post-mortem posterior cerebellum from 50 cases each of bipolar disorder (BPD), schizophrenia, 15 major depressive disorder (MDD) and 50 appropriate control samples obtained from two well-known brain collections (Stanley Medical Research Institute). HHV-6A and HHV-6B late proteins (indicating active infection) and viral DNA were detected more frequently (p < 0.001 for each virus) in human cerebellum in MDD and BPD relative to controls. These roseolovirus proteins and DNA were found less frequently in schizophrenia cases. Active HHV-6A and HHV-6B infection in cerebellar Purkinje cells were detected frequently in BPD and MDD cases. Furthermore, we found a significant association of HHV-6A infection with reduced Purkinje cell size, suggesting virus-mediated abnormal Purkinje cell function in these disorders. Finally, gene expression analysis of cerebellar tissue revealed changes in pathways reflecting an inflammatory response possibly to HHV-6A infection. Our results provide molecular evidence to support a role for active HHV-6A and HHV-6B infection in BPD and MDD.

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Impaired functioning in euthymic patients with bipolar disorder — HSV-1 as a predictor

Cited by 25 publications

References 43 publications

Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder

Cytomegalovirus seropositivity and serointensity are associated with hippocampal volume and verbal memory in schizophrenia and bipolar disorder

Association between Exposure to HSV1 and Cognitive Functioning in a General Population of Adolescents. The TRAILS Study

Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders

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