Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression

Jiang, Lili; Sui, Danyang; Qiao, Kaini; Dong, Hao-Ming; Chen, Luonan; Han, Ying

doi:10.1038/s41598-018-19674-7

Cited by 28 publications

(32 citation statements)

References 42 publications

(43 reference statements)

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“…Montreal Cognitive Assessment is an efficient and rapid screening tool for cognitive dysfunction involving memory, executive function, and attention (Jiang et al, 2018) and has moderate specificity and high sensitivity (Mclennan et al, 2011). Previous studies have found that MoCA scores significantly correlate with both structural and functional brain alterations in SCD Shu et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Liang

Zhao

Wei

et al. 2020

Front. Aging Neurosci.

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Background: Recently, subjective cognitive decline (SCD) has been described as the earliest at-risk state of Alzheimer's disease (AD), and drawn attention of investigators. Studies suggested that SCD-community individuals may constitute a more vulnerable population than SCD-clinic patients, therefore, to investigate the early changes of the brain may provide guidance for treatment of the disease. We sought to investigate the changes of structure and functional connectivity alternation of the hippocampus in individuals with SCD recruited from the community using structural and resting-state functional MRI (fMRI).Methods: Thirty-five SCD patients and 32 healthy controls were recruited. Resting-state fMRI data and high-resolution T1-weighted images were collected. Whole-brain voxelbased morphometry was used to examine the brain structural changes. We also used the hippocampal tail and the whole hippocampus as seeds to investigate functional connectivity alternation in SCD.Results: Individuals with SCD showed significant gray matter volume decreases in the bilateral hippocampal tails and enlargement of the bilateral paracentral lobules. We also found that individuals with SCD showed decreased hippocampal tail resting-state functional connectivity (rsFC) with the right medial prefrontal cortex (mPFC) and the left temporoparietal junction (TPJ), and decreased whole hippocampus rsFC with the bilateral mPFC and TPJ. These brain region and FC showing significant differences also showed significantly correlation with Montreal Cognitive Assessment (MoCA) scores.Conclusion: Individuals with SCD recruited from the community is associated with structural and functional changes of the hippocampus, and these changes may serve as potential biomarkers of SCD.

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Section: Discussionmentioning

confidence: 99%

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Liang

Zhao

Wei

et al. 2020

Front. Aging Neurosci.

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“…However, many groups have also observed lower connectivity between these regions in individuals with SCD [18,[76][77][78][79]. Others have reported no difference from control [60], or intricate patterns of greater and lower functional connectivity in individuals with SCD [51][52][53][54][55], suggesting that a complex reorganization of processing responsibilities across network nodes may occur. Multifaceted patterns of increased and decreased connectivity between regions could reflect breakdown in processing within a subnetwork that shifts processing load to more intact components of the broader network.…”

Section: Brain Network Functional Connectivity In Subjective Cognitivmentioning

confidence: 99%

Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Viviano

Damoiseaux

2020

Alz Res Therapy

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Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model where noisy signal propagation and inefficient signal processing across whole-brain networks may lead to the subjective experience of decline and discuss future research directions guided by this model.

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“…vIFC has successfully detected abnormalities in human brain dynamics during AD progression [5]. However, it remains unclear whether vIFC in healthy brains is associated with neurodevelopment, physiological or behavioral measurements.…”

Section: Discussionmentioning

confidence: 99%

“…The vIFC method has been described in detail in our previous publication [5]. Considering the three properties designed in vIFC, increased temporal variations, increased within-group correlations, and decreased between-group correlations, the formula is as follows: …”

Section: Methodsmentioning

confidence: 99%

“…Is there any critical transition or abrupt change in human brain dynamics at some spatiotemporal scale that may indicate neurodevelopment, physiology or behavior? vIFC, a recently proposed vertex-wise Index of Functional Criticality of human brain resting state fMRI time series [5], provides us with a possible opportunity to examine the critical transitions of the human brain and their associations with neurodevelopment, physiology, and behavior. vIFC has been proposed based on nonlinear dynamical theory as an efficient neuroimaging marker that indicates probabilities that a critical transition occurs in the absence of knowledge of the details of the realistic network connections [6].…”

Section: Introductionmentioning

confidence: 99%

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Functional criticality in the human brain: Physiological, behavioral and neurodevelopmental correlates

et al. 2019

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Understanding the critical features of the human brain at multiple time scales is vital for both normal development and disease research. A recently proposed method, the vertex-wise Index of Functional Criticality (vIFC) based on fMRI, has been testified as a sensitive neuroimaging marker to characterize critical transitions of human brain dynamics during Alzheimer’s disease progression. However, it remains unclear whether vIFC in healthy brains is associated with neuropsychological and neurophysiological measurements. Using the Nathan Kline Institute/Rockland lifespan cross-sectional datasets and openfMRI single participant longitudinal datasets, we found consistent spatial patterns of vIFC across the entire cortical mantle: the inferior parietal and the precuneus exhibited high vIFC. On a time scale of years, we observed that vIFC increased with age in the left ventral posterior cingulate gyrus. On a time scale of days and weeks, vIFC demonstrated the capacity to identify a link between anxiety and pulse. These results showed that vIFC can serve as a useful neuroimaging marker for detecting physiological, behavioral, and neurodevelopmental transitions. Based on the criticality theory in nonlinear dynamics, the current vIFC study sheds new light on human brain studies from a nonlinear perspective and opens potential new avenues for normal and abnormal human brain studies.

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Impaired Functional Criticality of Human Brain during Alzheimer’s Disease Progression

Cited by 28 publications

References 42 publications

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Functional criticality in the human brain: Physiological, behavioral and neurodevelopmental correlates

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