Impaired function of polymorphonuclear leukocytes in patients with burns and other trauma

Grogan, James B.; Miller, R C

doi:10.1097/00006534-197405000-00065

Cited by 8 publications

(8 citation statements)

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“…The function of NK cells is diminished following significant injury (362). Neutrophil dysfunction after significant thermal injuries has also been reported (44,137,175,242). Endothelial adherence of neutrophils is initially decreased after injury and then increases (374); however, the site of endothelial adhesion may not be at the point of injury, and this misguided neutrophil adhesion and activation contribute to neutrophil-mediated endothelial injury, which may play a significant role in the pathogenesis VOL.…”

Section: Innate Immune System Response To Burn Injurymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,595

1,345

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SUMMARYBurns are one of the most common and devastating forms of trauma. Patients with serious thermal injury require immediate specialized care in order to minimize morbidity and mortality. Significant thermal injuries induce a state of immunosuppression that predisposes burn patients to infectious complications. A current summary of the classifications of burn wound infections, including their diagnosis, treatment, and prevention, is given. Early excision of the eschar has substantially decreased the incidence of invasive burn wound infection and secondary sepsis, but most deaths in severely burn-injured patients are still due to burn wound sepsis or complications due to inhalation injury. Burn patients are also at risk for developing sepsis secondary to pneumonia, catheter-related infections, and suppurative thrombophlebitis. The introduction of silver-impregnated devices (e.g., central lines and Foley urinary catheters) may reduce the incidence of nosocomial infections due to prolonged placement of these devices. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary and burn wound care, and infection control practices.

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Section: Innate Immune System Response To Burn Injurymentioning

confidence: 99%

Burn Wound Infections

Church

Elsayed

Reid³

et al. 2006

Clin Microbiol Rev

1,595

1,345

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“…However, it should be pointed out that the PMN functions may deteriorate rapidly during acute illness or other conditions and then be a good predictor of near-future mortality (4,11).…”

Section: Discussionmentioning

confidence: 99%

Ageing Does Not Change Blood Granulocyte Bactericidal Capacity and Levels of Complement Factors 3 and 4

Palmblad¹,

Haak²

1978

Gerontology

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“…However, it is still disputed how far the clinical problems of the multiple organ distress syndrome (MODS), the systemic inflammatory response syndrome (SIRS), and the acute respiratory distress syndrome (ARDS) are due to the initial excessive inflammation, and how far they are a later consequence of immunosuppression or leakage into the circulation of Gramnegative organisms and endotoxin from the damaged gut (Jones et al 1990;Moore et al 1995). Some authors find a suppression of granulocyte chemotaxis and phagocytosis in patients affected by these conditions (Grogan and Miller 1975;Maderazo et al 1983), but others report overactivation of the granulocytes in patients with an adverse clinical course (Christou and Tellado 1989;Mannick 1993).…”

Section: Cytokinesmentioning

confidence: 99%

Immune responses to inflammation and trauma: a physical training model

Shephard¹,

Shek²

1998

Can. J. Physiol. Pharmacol.

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Physical activity and training have some potential as tools for examining immune responses to inflammation and trauma. Contributors to the present symposium review various aspects of the inflammatory process, including issues of lymphocyte recirculation and endotoxemia. They examine also the extent and nature of the immune disturbances induced by acute and chronic exercise and consider parallels between such responses and cellular manifestations of clinical sepsis. Factors modulating immune responses during physical activity include changes in the circulating levels of various cytokines, alterations in nutritional status, an altered expression of adhesion molecules, and the possible intervention of reactive species. Factors that can exacerbate exercise-induced changes include exposure to adverse environments, particularly hot conditions, and disturbances of the normal sleep-wakefulness cycle. Current research in exercise immunology finds clinical application in attempts to regulate aging, acute viral infections, and neoplasia.

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Impaired function of polymorphonuclear leukocytes in patients with burns and other trauma

Cited by 8 publications

References 0 publications

Burn Wound Infections

Burn Wound Infections

Ageing Does Not Change Blood Granulocyte Bactericidal Capacity and Levels of Complement Factors 3 and 4

Immune responses to inflammation and trauma: a physical training model

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